2012
DOI: 10.1590/s0102-86502012000900004
|View full text |Cite
|
Sign up to set email alerts
|

Protective effect of N-acetylcysteine on kidney as a remote organ after skeletal muscle ischemia-reperfusion

Abstract: PURPOSE: To investigate whether N-acetylcysteine has a protective effect against renal injury as a remote organ after skeletal muscle ischemia-reperfusion in rats. METHODS: Twenty Wistar male rats were divided randomly into two experimental groups: group ischemia-reperfusion (group I) and group ischemia-reperfusion + N-acetylcysteine (group II). After ketamine and xylazine anesthesia, femoral artery was exposed. All animals were undergone 2h of ischemia by occlusion femoral artery and 24h of reperfusion. Rats … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
10
1

Year Published

2013
2013
2021
2021

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 21 publications
(11 citation statements)
references
References 31 publications
(37 reference statements)
0
10
1
Order By: Relevance
“…A secondary damage might then occur later, when kidneys mitochondrial defences are overloaded by a higher amount of oxidative stress and inflammatory factors. Accordingly, we did not observe histological change in the kidney early after reperfusion, but other authors demonstrated tubular cell necrosis after 24 h of reperfusion following a 2-hour femoral artery occlusion [32]. …”
Section: Discussioncontrasting
confidence: 70%
“…A secondary damage might then occur later, when kidneys mitochondrial defences are overloaded by a higher amount of oxidative stress and inflammatory factors. Accordingly, we did not observe histological change in the kidney early after reperfusion, but other authors demonstrated tubular cell necrosis after 24 h of reperfusion following a 2-hour femoral artery occlusion [32]. …”
Section: Discussioncontrasting
confidence: 70%
“…Major reasons of acute extremity ischemia are thrombosis and embolism 3 . Additionally ischemia reperfusion (IR) can be caused by numerous events such as trauma, various orthopaedic surgery and freeflap reconstruction 4,5 . A huge number of consecutive events are initiated by free oxygen radicals.…”
Section: Introductionmentioning
confidence: 99%
“…NAC treatment was successful in ameliorating serum creatinine levels in the BDL animals. NAC has been shown to reduce creatinine levels along with exerting protective effect against renal injury as a remote organ after skeletal muscle ischemia-reperfusion in rats [37]. The levels of MDA and conjugated dienes in liver and kidneys from BDL animals were observed to be significantly higher as compared to those observed in SC animals.…”
Section: Discussionmentioning
confidence: 90%