Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis

Tokgöz, Bülent; Uçar, Cahit; Koçyiğit, İsmail; Somdas, Mehmet Akıf; Ünal, Aydın; Vural, Alperen; Sipahioğlu, Murat Hayri; Oymak, Oktay; Utaş, Cengiz

doi:10.1093/ndt/gfr211

Cited by 45 publications

(36 citation statements)

References 29 publications

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“…NAC blocked gentamicin, histopathologically and audiologically antagonizing its ototoxic effect. This was concordant with what we have found in our previous clinical study [16] , in which NAC antagonized the ototoxic effect (of a different aminoglicoside) without interfering with the antibiotic effect.…”

Section: Discussionsupporting

confidence: 93%

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N-acetylcysteine Prevents Gentamicin Ototoxicity in a Rat Model

Somdas¹,

Korkmaz²,

Gürgen³

et al. 2015

Int Adv Otol

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OBJECTIVE:The possible preventive effect of N-acetylcysteine (NAC) in gentamicin ototoxicity was studied with auditory brain stem responses (ABRs), otoacoustic emissions (OAEs), and histopathological investigation of the cochlea. MATERIALS and METHODS:This study is conducted on 36 rats in three groups. Gentamicin, gentamicin plus NAC, and NAC alone were intraperitoneally administered for 15 days. The rats were sacrificed to study the cochleas after testing hearing levels. RESULTS:ABR thresholds and OAEs were attenuated in the gentamicin group, in which apoptosis was detected with histopathological investigation. The group that received NAC in addition to gentamicin had better ABR thresholds and better OAEs. The histopathological evidence of apoptosis in was considerably less in this group. CONCLUSION:Gentamicin ototoxicity can be detected by ABR and OAE testing in rats, and NAC may protect the cochlear cells from apoptosis.

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Section: Discussionsupporting

confidence: 93%

“…Intraperitoneal aminoglycoside had caused a low and high frequency dose-related hearing loss. In that study, N-acetylcysteine (NAC) had prevented ototoxicity and had a curative effect on hearing loss at high-frequencies [16] .…”

Section: Introductionmentioning

confidence: 98%

N-acetylcysteine Prevents Gentamicin Ototoxicity in a Rat Model

Somdas¹,

Korkmaz²,

Gürgen³

et al. 2015

Int Adv Otol

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show abstract

“…NAC is well known drug of choice for emergency treatment of APAP poisoning and related toxicity (Tokgoz et al, 2011). NAC allows the generation of sufficient level of glutathione to react with toxic intermediates NAPQI and prevent hepatic necrosis.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential ofMoringa oleiferaextracts against acetaminophen-induced hepatotoxicity in rats

Sharifudin

Fakurazi²,

Hidayat

et al. 2012

Pharmaceutical Biology

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“…Two of these trials were open-label,14 16 and one was a randomised, placebo-controlled trial 17. Patients received 600 mg NAC twice daily for the duration of aminoglycoside treatment,16 for a total of 14 days17 or for up to 7 days14 after completion of aminoglycoside treatment. The aminoglycosides used were amikacin (n=2) and gentamicin (n=1).…”

Section: Resultsmentioning

confidence: 99%