Protective effect of Mollugo nudicaulis Lam. on acute liver injury induced by perchloroethylene in experimental rats

Rajamanikandan, Sundaraj; Sindhu, Thangaraj; D, Durgapriya; Sophia, Dominic; Ragavendran, Paramasivam; Gopalakrishnan, Vishrawas

doi:10.1016/s1995-7645(12)60161-8

Cited by 7 publications

(6 citation statements)

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“…Rajamanikandan et al (2012) observed increased serum AST, ALT, and alkaline phosphatase, along with histopathology changes (minimal periportal lymphocytic infiltration, inflammation, and hepatocellular necrosis; incidences not reported) in female Wistar rats given 14 consecutive daily gavage doses of 1,000 mg/kg/day tetrachloroethylene. The authors also measured increased levels of hepatic lipid oxidation as well as decreased antioxidant levels (Rajamanikandan et al 2012).…”

Section: Health Effectsmentioning

confidence: 72%

“…Increased relative liver weights, increased serum ALT, and hepatocellular hypertrophy were observed in female rats treated by gavage with tetrachloroethylene in corn oil at a dose of 1,500 mg/kg/day for 14 days, but not at 500 mg/kg/day (Berman et al 1995). Rajamanikandan et al (2012) observed increased serum AST, ALT, and alkaline phosphatase, along with histopathology changes (minimal periportal lymphocytic infiltration, inflammation, and hepatocellular necrosis; incidences not reported) in female Wistar rats given 14 consecutive daily gavage doses of 1,000 mg/kg/day tetrachloroethylene. The authors also measured increased levels of hepatic lipid oxidation as well as decreased antioxidant levels (Rajamanikandan et al 2012).…”

Section: Health Effectsmentioning

confidence: 93%

“…No human data were located regarding oral or dermal intermediate-duration exposure to tetrachloroethylene. The target organs identified in animal studies of intermediate-duration oral or inhalation exposure to tetrachloroethylene include the nervous system (Carpenter 1937;Karlsson et al 1987;Kyrklund et al 1988;Mattsson et al 1992Mattsson et al , 1998Rosengren et al 1986), liver (Boverhof et al 2013;Buben and O'Flaherty 1985;Carpenter 1937;Hayes et al 1986;Jonker et al 1996;Kylin et al 1965;Kyrklund et al 1988;NTP 1986;Odum et al 1988;Philip et al 2007;Rajamanikandan et al 2012;Rowe et al 1985;Story et al 1986), kidney (Carpenter 1937;Ebrahim et al 1996;Green et al 1990;Hayes et al 1986;Jonker et al 1996;NTP 1986;Rowe et al 1985), and immune system (Seo et al 2008a(Seo et al , 2012. These studies were conducted in a variety of animal species including mice, rats, guinea pigs, and gerbils.…”

Section: Acute-durationmentioning

confidence: 99%

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Physicochemical properties

Brooke¹

2014

Essentials of Environmental Public Health Science

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Managing Hazardous Materials Incidents is a three-volume set of recommendations for on-scene (prehospital) and hospital medical management of patients exposed during a hazardous materials incident (see https://www.atsdr.cdc.gov/MHMI/index.asp). Volumes I and II are planning guides to assist first responders and hospital emergency department personnel in planning for incidents that involve hazardous materials. Volume III-Medical Management Guidelines for Acute Chemical Exposures-is a guide for health care professionals treating patients exposed to hazardous materials.Fact Sheets (ToxFAQs™) provide answers to frequently asked questions about toxic substances (see https://www.atsdr.cdc.gov/toxfaqs/Index.asp). Other Agencies and OrganizationsThe National Center for Environmental Health (NCEH) focuses on preventing or controlling disease, injury, and disability related to the interactions between people and their environment outside the workplace. Contact: NCEH,

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Section: Health Effectsmentioning

confidence: 72%

Section: Health Effectsmentioning

confidence: 93%

Section: Acute-durationmentioning

confidence: 99%

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Physicochemical properties

Brooke¹

2014

Essentials of Environmental Public Health Science

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“…If hepatopathy occurred in an animal, bilirubin enzymes come into the bloodstream in conformity with the extent of liver damage. Measurement of bilirubin in the bloodstream is the conventional indicator of liver diseases or damages caused by the toxicants [60][61][62]. In normal condition, the measurement of bilirubin and its components in the blood reflects the liver function or hemolysis in animals [63].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Ameliorative Potential of Caffeic Acid Against Hepatotoxicity and Nephrotoxicity Induced by Mercuric Chloride in Albino Wistar Rats

Manju¹,

Jagadeesan²

2019

Asian J Pharm Clin Res

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Objective: The current experimental study is designed to scrutinize the possible defensive effect of caffeic acid (CA) against mercury-induced hepatotoxicity in male rats. Methods: During the treatment periods, a sub-lethal dose of HgCl2 (1.29 mg/kg body weight) was given to rats for 15 days through oral administration and the CA was administrated for 15 days, on mercuric intoxicated rats were observed. After completing the programmed period of experimental work, the blood was drawn through a micro glass tube in the ocular region and separated the serum by centrifuge. Results: The subsequent serum enzymes were analyzed as the alkaline phosphatase (ALP), alanine transferase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH). Further, the bilirubin, albumin, total cholesterol, urea, and creatinine levels were also noticed in the blood serum of both normal and treated rats. CA is one of the well-known phenolic compounds, and a strong antioxidant helps to prevent oxidative damage and reducing oxidative stress. The biological action of liver biomarker enzymes such as ALT, AST, ALP, and LDH was significantly enhanced and at the same time the drastic increased in the level of albumin was all together decreased. The level of bilirubin, total cholesterol, urea, and creatinine was significantly increased in HgCl2 intoxicated rats. When the treatment of CA on mercury intoxicated rats for 15 days (5 mg/kg body weight), in the serum enzymes (ALT, AST, ALP, and LDH) also declined to near normal level. The level of bilirubin, total cholesterol, urea, and creatinine activities was also significantly declined to near normal level when compared to mercury-treated group. The level of albumin was significantly enhanced. The CA alone treatment showed the enhanced antioxidant levels and not any alteration in the levels of biochemical parameters when compared to control. Conclusion: These observations of the present experimental work demonstrated the detoxify effects and defensive effect of CA against HgCl2 toxicity in liver tissue.

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“…Mollugo nudicaulis Lam. ( M.nudicaulis ) is one of the Indian medicinal plants which belongs to Molluginaceae family [ 9 ]. Traditionally, it is used in Indian phytotherapy to treat wounds, cough, cold, fever, inflammation, cancer, urinary and kidney infections [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

MTT assay based inhibition analysis of A2780 cells proliferation using Mollugo nudicaulis Lam. extract with CXCR4 and HER2 expression

Palanisamy¹

2021

Bioinformation

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It is of interest to document the inhibition of A2780 cell proliferation using Mollugo nudicaulis Lam. (M. nudicaulis) extract by MTT assay and by monitoring the CXCR4 and HER2 expression through RT-PCR analysis. Results shown that the n-hexane extract of M. nudicaulis have anticancer activity IC50 values of 32.46ą0.92 Ĵg/mL on A2780 cell lines. It is further found that the CXCR4 and HER2 mRNA and protein expression were significantly reduced in M. nudicaulis treated A2780 cell lines. Thus, the n-hexane extract of M. nudicaulis is a natural source of bioactive compounds as potential anticancer agents.

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Protective effect of Mollugo nudicaulis Lam. on acute liver injury induced by perchloroethylene in experimental rats

Abstract: The results led to the conclusion that M. nudicaulis possess hepatoprotective and antioxidant activities against perchloroethylene-induced hepatotoxicity in rats.

Cited by 7 publications

References 24 publications

Physicochemical properties

Physicochemical properties

In Vivo Ameliorative Potential of Caffeic Acid Against Hepatotoxicity and Nephrotoxicity Induced by Mercuric Chloride in Albino Wistar Rats

MTT assay based inhibition analysis of A2780 cells proliferation using Mollugo nudicaulis Lam. extract with CXCR4 and HER2 expression

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