Protective effect of methionine on the intestinal oxidative stress and microbiota change induced by nickel

Wu, Biao; Liu, Yiwei; Zhang, Jie; Mou, Pan; Li, Jia; Xu, Zhao‐Dong; Song, Baolin

doi:10.1016/j.ecoenv.2022.114037

Cited by 12 publications

(7 citation statements)

References 42 publications

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“…In addition, existing research has confirmed that heavy metal deposits, such as Pb and Ni, can lead to a reduction in the volume of the cerebral cortex. Methionine can chelate and remove lead and nickel from the brain tissue, thereby reducing oxidative stress and protecting the brain structure ( 6 , 19 ). These studies suggest that rational methionine supplementation may interfere with the antioxidant capacity of an organism, thereby reducing DNA damage, protecting the brain structure, and delaying neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

Association between human blood metabolites and cerebral cortex architecture: evidence from a Mendelian randomization study

Jiang,

Sun,

Liu

2024

Front. Neurol.

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BackgroundDysregulation of circulating metabolites may affect brain function and cognition, associated with alterations in the cerebral cortex architecture. However, the exact cause remains unclear. This study aimed to determine the causal effect of circulating metabolites on the cerebral cortex architecture.MethodsThis study utilized retrieved data from genome-wide association studies to investigate the relationship between blood metabolites and cortical architecture. A total of 1,091 metabolites and 309 metabolite ratios were used for exposure. The brain cortex surface area and cortex thickness were selected as the primary outcomes in this study. In this study, the inverse variance weighting method was used as the main analytical method, complemented by sensitivity analyses that were more robust to pleiotropy. Furthermore, metabolic pathway analysis was performed via MetaboAnalyst 6.0. Finally, reverse Mendelian randomization (MR) analysis was conducted to assess the potential for reverse causation.ResultsAfter correcting for the false discovery rate (FDR), we identified 37 metabolites and 9 metabolite ratios that showed significant causal associations with cortical structures. Among these, Oxalate was found to be most strongly associated with cortical surface area (β: 2387.532, 95% CI 756.570–4018.495, p = 0.037), while Tyrosine was most correlated with cortical thickness (β: −0.015, 95% CI −0.005 to −0.025, p = 0.025). Furthermore, pathway analysis based on metabolites identified six significant metabolic pathways associated with cortical structures and 13 significant metabolic pathways based on metabolite ratios.ConclusionThe identified metabolites and relevant metabolic pathways reveal potential therapeutic pathways for reducing the risk of neurodegenerative diseases. These findings will help guide health policies and clinical practice in treating neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Association between human blood metabolites and cerebral cortex architecture: evidence from a Mendelian randomization study

Jiang,

Sun,

Liu

2024

Front. Neurol.

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“…Given the aforementioned facts about Staphylococcus aureus, it still remains an important dominant factor in the mechanism of iAD performance ( Table 2 ), but new emerging bacterial strains, such as Colidextribacter, seem to play an important role in this particular condition. 33 …”

Section: Discussionmentioning

confidence: 99%

“…32 Studies on mice that have been fed with nickel showed a decreased abundance of Colidextribacter, a bacterium that produces inosine, which can reduce the malondialdehyde concentration (lipid peroxidation product). [33][34][35] Other Than Filaggrin Previous studies have shown that the filaggrin (FLG) gene mutation is not one of the etiopathological features of iAD, but later articles discovered an (onco-) protein expressed in various epithelial tissues such as the skin and superior gastrointestinal tract, called suprabasin (SBSN). 36 It is produced by spinous cells of the stratified epithelia.…”

Section: Metal Sensitivity and Type 1 Immunitymentioning

confidence: 99%

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Insights into Intrinsic Atopic Dermatitis: immunogenicity, Dysbiosis, and Imaging (Reflectance Confocal Microscopy, Optical Coherence Tomography)

Gavrilita,

Silion,

Bitca

et al. 2024

CCID

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“…Although nickel is an essential trace element for the body, excessive nickel can induce the production of ROS. Excessive ROS can cause lipid peroxidation, producing a large amount of MDA ( 43 ). MDA is a key indicator that reflects the degree of oxidative damage to the body ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of hesperidin on the histological structure, oxidative stress, and apoptosis in the liver and kidney induced by NiCl2

Chen,

Fan,

Chen

et al. 2024

Front. Vet. Sci.

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The aim of this study was to investigate the effect of hesperidin on the liver and kidney dysfunctions induced by nickel. The mice were divided into six groups: nickel treatment with 80 mg/kg, 160 mg/kg, 320 mg/kg hesperidin groups, 0.5% CMC-Na group, nickel group, and blank control group. Histopathological techniques, biochemistry, immunohistochemistry, and the TUNEL method were used to study the changes in structure, functions, oxidative injuries, and apoptosis of the liver and kidney. The results showed that hesperidin could alleviate the weight loss and histological injuries of the liver and kidney induced by nickel, and increase the levels of lactate dehydrogenase (LDH), alanine aminotransferase (GPT), glutamic oxaloacetic transaminase (GOT) in liver and blood urea nitrogen (BUN), creatinine (Cr) and N-acetylglucosidase (NAG) in kidney. In addition, hesperidin could increase the activities of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px) in the liver and kidney, decrease the content of malondialdehyde (MDA) and inhibit cell apoptosis. It is suggested that hesperidin could help inhibit the toxic effect of nickel on the liver and kidney.

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Protective effect of methionine on the intestinal oxidative stress and microbiota change induced by nickel

Cited by 12 publications

References 42 publications

Association between human blood metabolites and cerebral cortex architecture: evidence from a Mendelian randomization study

Association between human blood metabolites and cerebral cortex architecture: evidence from a Mendelian randomization study

Insights into Intrinsic Atopic Dermatitis: immunogenicity, Dysbiosis, and Imaging (Reflectance Confocal Microscopy, Optical Coherence Tomography)

Effects of hesperidin on the histological structure, oxidative stress, and apoptosis in the liver and kidney induced by NiCl2

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