Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exercise

Biçer, Mürsel; Akıl, Mustafa; Baltacı, Abdülkerim Kasım; Moğulkoç, Rasim; Sivrikaya, Abdullah; Günay, Mehmet; Akkuş, Hasan

doi:10.4149/bll_2012_158

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…In this study, MDA concentration in serum from the FT group was the highest, and was positively associated with intensity of swimming exercise (Figure ). The ratio of FT/CT was 1.78‐fold higher than a previous result reported by Bicer et al, indicating that swimming exercise significantly increased MDA concentration.…”

Section: Discussioncontrasting

confidence: 67%

Proteomic response of the rat liver in differential swimming modes

Chen

Yang

Wang

et al. 2018

Clin Exp Pharma Physio

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Moderate exercise helps improve competition results, providing a balanced muscle tone and biochemical activity, whereas excessive training disrupts the balance between training and recovery, causes harm to the organism, and leads to overtraining syndrome (OTS). To explore the mechanisms of different protein expressions during training and acquisition of immunity, we used proteomic analyses to investigate the differences of liver-protein expressions between 2 swimming modes. Sprague-Dawley rats were randomly divided into control (CT), fatigue training (FT), and exhaustive training (ET) groups, and liver tissues from each group were subjected to 2-dimensional electrophoresis (2DE). A total of 4518 protein spots were detected in 9 replicates, and 45 protein spots exhibited a >2-fold difference in expression (P < .05), 31 of which was successfully identified by mass spectrometry. SERPINA3K expression decreased markedly during 2 stages from CT → FT and FT → ET, while DDT, RHOT1, and RBP4 decreased significantly only from CT → ET but not from the former 2 stages. By contrast, KRT8, PCBD1, KRT18, PRDX1, and ACY1A showed significant >2-fold increase in expression in either the CT → FT or FT → ET stages. Bioinformatic analyses showed that among the identified proteins, 30.2%, 54.18%, and 15.62% were involved in biological processes, molecular functions, and cell composition, respectively. Notably, PCBD1, PRDX1, and PPP1CB were involved in redox processes, while PPP1CB was only expressed in the FT group. RGN, PSMB9, and AGT, commonly recognized as oxidative stress biomarkers, may involve in regulating homeostasis in the locomotor mode and may provide diagnostic criteria for the occurrence and prevention of exercise-induced fatigue and OTS.

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Section: Discussioncontrasting

confidence: 67%

Proteomic response of the rat liver in differential swimming modes

Chen

Yang

Wang

et al. 2018

Clin Exp Pharma Physio

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“…Bicer et al. demonstrated that melatonin administration prevented an increase in free radical production associated with diabetes and an acute swimming exercise. The authors concluded that melatonin administration may help regulate redox status in exercising diabetics .…”

Section: Resultsmentioning

confidence: 99%

Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis

Borges

Dermargos

Silva

et al. 2015

Journal of Pineal Research

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Strenuous exercise is detrimental to athletes because of the overproduction of reactive oxygen species. Melatonin, a classic antioxidant, has been shown to exhibit beneficial effects regarding intense exercise and tissue repair. In this study, we evaluated the onset and resolution of inflammation in melatonin-treated and nontreated rats subjected to a strenuous exercise session. We also analyzed the formation of thiobarbituric acid reactive substances (TBARS) and the activities of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). Control and treated rats were subjected to exhaustive exercise after a period of 10 days of melatonin treatment (20 mg/dL). Plasma and muscle levels of tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), cytokine-induced neutrophil chemoattractant-2-alpha/beta (CINC-2α/β), l-selectin, macrophage inflammatory protein-3-alpha (MIP-3α), and vascular endothelial growth factor (VEGF) were measured prior to, immediately after, and 2 hr after exercise. Our data revealed decreases in the muscle concentrations of IL-1β (35%), TNF-α (13%), IL-6 (48%), and TBARS (40%) in the melatonin-treated group compared with the control group. We also observed decreases in the plasma concentrations of IL-1β (17%) in the melatonin-treated group. VEGF-α concentrations and SOD activity increased by 179% and 22%, respectively, in the melatonin-treated group compared with the control group. We concluded that muscle inflammation and oxidative stress resulting from exhaustive exercise were less severe in the muscles of melatonin-treated animals than in the muscles of control animals. Thus, melatonin treatment may reverse exercise-induced skeletal muscle inflammation and stimulate growth factor synthesis.

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“…Melatonin has been reported to be beneficial in reducing hepatic MDA levels in diabetes. 37,52,54,55 Dias et al and Sirovina et al found quercetin effective in reducing hepatic MDA levels in diabetes. 9,48 Atef and Ezz reported that increased MDA levels in diabetes was reduced by resveratrol administration.…”

Section: Discussionmentioning

confidence: 99%

“…32,41,54 Korkmaz et al and Bicer et al found that GSH levels were significantly increased by melatonin administration. 54,55 Sanders et al reported decreased GSH levels and CAT activity, but increased SOD activity in diabetic conditions. 56 However, Guven et al reported no significant difference between diabetes and control group in hepatic GSH levels.…”

Section: Discussionmentioning

confidence: 99%

Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats

et al. 2015

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In this study, effects of melatonin, quercetin and resveratrol on hepatocellular injury in streptozotocin (STZ)-induced experimental diabetes were aimed to be investigated by histological and biochemical methods. Thirty-five male Wistar albino rats were divided into five groups, namely, control, diabetes (STZ 45 mg/kg/single dose/intraperitoneally (ip)), diabetes + melatonin (10 mg/kg/30 days/ip), diabetes + quercetin (25 mg/kg/30 days/ip) and diabetes + resveratrol (10 mg/kg/30 days/ip). Initial and final blood glucose levels and body weights (BWs) were measured. At the end of the experimentation, following routine tissue processing procedure, sections were stained with haematoxylin–eosin (H-E), periodic acid Schiff and Masson’s trichrome. Tissue malondialdehyde (MDA) and glutathione (GSH) levels and superoxide dismutase (SOD) and catalase (CAT) activities were examined. The diabetic rats had significantly higher blood glucose levels than those of control rats ( p = 0.0001). Mean BWs of diabetic rats were significantly decreased when compared with the control rats ( p = 0.0013). Histopathological alterations including cellular glycogen depletion, congestion, sinusoidal dilatation, inflammation and fibrosis were detected in diabetes group. On the other hand, histopathological changes markedly reduced in all of the treatment groups ( p = 0.001). Mean tissue MDA level was increased but mean tissue CAT and SOD activities and GSH levels were decreased in the diabetes group. Melatonin, quercetin and resveratrol administered diabetic rats showed an increase in CAT activities and GSH levels and a decrease in MDA levels ( p < 0.05, for all). Melatonin, quercetin and resveratrol administrations markedly reduced hepatocellular injury in STZ-induced experimental diabetes.

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Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exercise

Cited by 8 publications

References 20 publications

Proteomic response of the rat liver in differential swimming modes

Proteomic response of the rat liver in differential swimming modes

Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis

Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats

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