Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats

Bilginoglu, Ayca

doi:10.5543/tkda.2014.36089

Cited by 32 publications

(39 citation statements)

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“…In an earlier research, it was proposed that doxorubicin raised MDA level (28). In our fi ndings, a reduction in activities of SOD, GPx and CAT in the adriamycin-induced group may have taken place because of improved generation of ROS such as superoxide and hydrogen peroxide which in turn bring about antioxidant enzymes inhibition (29). The treatment with pravastatin in part preserved the structural alterations resulting in morphology near to that of control group.…”

Section: Discussionmentioning

confidence: 55%

Protective effect of pravastatin on doxorubicin-induced hepatotoxicity

Mansouri¹,

Jangaran²,

Ashtari³

2017

BLL

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Section: Discussionmentioning

confidence: 55%

Protective effect of pravastatin on doxorubicin-induced hepatotoxicity

Mansouri¹,

Jangaran²,

Ashtari³

2017

BLL

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“…In the present study, melatonin had its improvement activity through various mechanisms including its antiapoptotic and antioxidants effects [11,12] to reduce the effects of free radicals. Furthermore, the concurrent treatment with melatonin might be led to inhibition of peroxidation of lipid.…”

Section: Discussionmentioning

confidence: 68%

“…The pineal gland is inactive in the day time but it is activated and starts to actively produce melatonin in the darkness. MEL participates in circadian rhythm regulation and has main role in anti aging processes [11,12] .…”

Section: Introductionmentioning

confidence: 99%

The Possible Protective Role of Melatonin on Doxorubicin Induced Cardiomyopathy of Adult Male Albino Rats

Yassien

Elsaid

2017

Egyptian Journal of Histology

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Introduction: Doxorubicin is one of the major antitumor treatment. The essential limiting factor of using this drug is the production of cardiotoxicity. However, melatonin is a powerful antioxidant that may protect the heart. Aim: This study was aimed to study possible protective role of melatonin in adult male albino rats following doxorubicin administration Material and Method: In this study, 40 adult male albino rats were used. They were divided into four groups (10 rats for each): control group, Melatonin group, Doxorubicin group and Doxorubicin & Melatonin group. Heart specimens were obtained at the end and processed. Results: Light studies showed degenerative changes. Some fibers showed dark acidophilic cytoplasm and pyknotic nuclei. Apoptosis were detected where the nuclei varying from peripheral condensation of chromatin up to pyknosis, confirmed with positively caspase-3 activity. Dilatation of the vessels with mononuclear cellular infiltrations and deposited collagen fibers were seen. Ultrastructural examination showed disarrangement of the sarcomeres, disruption of microfilaments and Z-line, the number and size of mitochondria apparently increased, dilated SER and T tubules were also noticed. The presence of oval shaped cells (Telocyte) with thin long processes (Telopodes) were detected. Conclusion: From this study, it was concluded that, melatonin markedly suppressed cardiomyopathy induced by doxorubicin.

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“…The level of HDL in the DOX‐NE group was significantly higher than that in the DOX‐Solution group. Bilginoğlu et al reported that the injection of DOX (at a cumulative dose of 18 mg/kg, i.p.) to Wistar‐albino rats on the 5th, 6th and 7th day elevated the level of TAG and decreased the HDL level.…”

Section: Discussionmentioning

confidence: 99%

Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma

Alkreathy

Alkhatib

Musaddi

et al. 2019

Clin Exp Pharma Physio

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Summary Doxorubicin (DOX) is the most commonly used anticancer drug; however, it has limited use because prolonged administration may result in severe cardiotoxicity. Simvastatin (SIM), generally prescribed for hypercholesterolaemia, has also shown salubrious results in the monotherapy or combinational drug therapy of different cancers in various models. Nanoparticle drug delivery systems are a novel way of improving therapeutics and also improving the absorption and specificity of drugs towards tumour cells. In this study, we exploited this technology to increase drug specificity and minimize imminent adverse effects. In this study, the antitumour activity of the combination formulas of DOX and SIM, either loaded in water (DOX‐SIM‐Solution) or nanoemulsions (NEs) (DOX‐SIM‐NE), was evaluated in a Swiss albino mouse model of Ehrlich ascites carcinoma. The anticancer effect was assessed by quantifying the change in body weight, mean survival time, and percent increase in lifespan (%ILS), determining haematological and serum biochemical parameters (liver function test, kidney function test and lipid profile parameters) as well as studying the histopathological alterations in liver tissues. We observed a clear increase in %ILS of the DOX‐SIM‐Solution group (265.30) that was double the %ILS of the DOX‐SIM‐NE group (134.70). However, DOX‐SIM‐NE had a non‐toxic effect on the haematological parameters, whereas DOX‐SIM‐Solution increased the levels of haemoglobin and lymphocytes. Furthermore, the encapsulation of SIM and DOX into NEs improved the levels of all serum biochemical parameters compared to the DOX‐SIM‐Solution. A reduction in the side effects of DOX‐SIM‐NE on the liver was also established using light microscopy, which revealed that the morphologies of the hepatocytes of the mice were less affected by administration of the DOX‐SIM‐NE treatment than with the DOX‐SIM‐Solution treatment. The study showed that incorporating SIM into the DOX‐loaded‐NE formulation remarkably improved its efficiency and simultaneously reduced its adverse effects.

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Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats

Abstract: Melatonin has a protective effect on the heart against adriamycin-induced cardiotoxicity in rats.

Cited by 32 publications

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Protective effect of pravastatin on doxorubicin-induced hepatotoxicity

Protective effect of pravastatin on doxorubicin-induced hepatotoxicity

The Possible Protective Role of Melatonin on Doxorubicin Induced Cardiomyopathy of Adult Male Albino Rats

Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma

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