Protective effect of marine brown algal polyphenols against oxidative stressed zebrafish with high glucose

Kim, Eun-A.; Kang, Min‐Cheol; Lee, Ji-Hyeok; Kang, Ning; Lee, Wonwoo; Oh, Jae-Young; Yang, Hye-Won; Lee, Jung-Suck; Jeon, You‐Jin

doi:10.1039/c5ra00338e

Cited by 38 publications

(27 citation statements)

References 27 publications

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“…Although the heart rate of embryos increased as the concentration of MRBS increased from 0.31 to 2.5 mg/ml, the heart rate significantly decreased at the sugar concentration of 5 mg/ml and only slightly increased at the sugar concentration of 10 mg/ml. Kim et al (2015) reported that phenolic compounds may affect the heartbeat of aquatic fish. For instance, they have found that phlorotannin isolated from a brown alga considerably decreased the rate heart of zebrafish embryos treated with 150 mM glucose.…”

Section: Effects Of Sugar Solutions On Heart Ratementioning

confidence: 99%

Antioxidant activity, nutritional and physicochemical characteristics, and toxicity of minimally refined brown sugar and other sugars

Azlan

Khoo

Sajak

et al. 2020

Food Science & Nutrition

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Minimally refined brown sugar (MRBS) is a brown sugar derived from sugarcane that has a low glycemic index. This study aimed to determine and compare the antioxidant contents and nutritional and physicochemical properties of MRBS, refined sugar (RS), and brown sugar (BS). In addition, the toxicity of these sugars was evaluated via in vitro cytotoxicity method and by using a zebrafish model. Results showed that MRBS was better than the two other sugars because it has a lower moisture content and higher ash content. The contents of potassium and manganese of MRBS were higher than those of the two other sugars. Surprisingly, MRBS also contained selenium, which was not detected in RS and BS. The major phenolics in MRBS are 4‐hydroxybenzoic acid, chlorogenic acid, protocatechuic acid, trans‐Ferulic acid, and apigenin. All sugar solutions and their antioxidant‐containing extracts were not cytotoxic to 3T3‐L1 adipocytes.

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Section: Effects Of Sugar Solutions On Heart Ratementioning

confidence: 99%

Antioxidant activity, nutritional and physicochemical characteristics, and toxicity of minimally refined brown sugar and other sugars

Azlan

Khoo

Sajak

et al. 2020

Food Science & Nutrition

View full text Add to dashboard Cite

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“…Phlorotannins from the edible seaweed E. cava have been shown to have sedative activity by showing positive allosteric modulation of GABA A receptors (Cho et al., , ). Furthermore, they have also been shown to have protective effects against oxidative stress in zebrafish with high glucose levels (Kim et al., ). They are a potential candidates for the treatment of Alzheimer's disease (Choi, Lee, Shin, & Lee, ).…”

Section: Biologically Active Phenolics and Pigments From Seaweedsmentioning

confidence: 99%

Metabolites Unravel Nutraceutical Potential of Edible Seaweeds: An Emerging Source of Functional Food

Tanna

Mishra

2018

Comp Rev Food Sci Food Safe

101

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Functional foods are nutritional compounds which also provide health and medicinal benefits. Daily food intake has much impact on the quality of life, and therefore inclusion of functional foods is now essential to our diet. Nutraceuticals are neither food nor drug but are added to food to provide extra nutritional and physiological properties. Though nutraceutical compounds provide minimal actions, their regular involvement in the diet can provide major and long‐term health benefits. Global demand for additional and sustainable biomass for the production of important metabolites with nutraceutical potential has resulted in renewed interest in seaweeds. Seaweeds have been consumed from ancient times in Asian areas, and in recent times they have been demonstrated to possess many medicinal effects. Seaweeds are considered a rich source of various nutritional ingredients and metabolites that have pharmaceutical properties. It has been observed that total protein, from terrestrial plants such as soybean and wheat, produces an allergic response on consumption. Therefore, seaweed proteins can be considered a promising source for food industries. Overall, seaweeds are a rich source of PUFAs, metabolites, proteins, sulfated polysaccharides, vitamins, and minerals, which are all responsible for different bioactivities; they are therefore considered a promising functional food (nutraceutical). In this review we discuss the nutraceutical potential of seaweeds regarding different metabolites (primary and secondary), variation in composition, probable biological applications, limitations, research gaps, and future prospects.

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“…Dieckol at the same dose also decreased the oxidative effects caused by high glucose, by significantly reducing heart rate, ROS, lipid peroxidation, and cell death in zebrafish (Table 1) [60]. Furthermore, high glucose levels induced the over-expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), whereas 5 treatment reduced it [60].…”

Section: Dieckolmentioning

confidence: 97%

“…Reduction of heart rate (13%), ROS formation (35%), NO level (18%), lipid peroxidation (10%), and cell death (10%) in high glucose-induced oxidative stress. Reduction of over-expression of iNOS (20%) and COX-2 (15%) [60].…”

Section: Zebrafish Embryos 20 µMmentioning

confidence: 99%

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

et al. 2019

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Macroalgae are increasingly viewed as a source of secondary metabolites with great potential for the development of new drugs. In this development, in vitro studies are only the first step in a long process, while in vivo studies and clinical trials are the most revealing stages of the true potential and limitations that a given metabolite may have as a new drug. This literature review aims to give a critical overview of the secondary metabolites that reveal the most interesting results in these two steps. Phlorotannins show great pharmaceutical potential in in vivo models and, among the several examples, the anti-dyslipidemia activity of dieckol must be highlighted because it was more effective than lovastatin in an in vivo model. The IRLIIVLMPILMA tridecapeptide that exhibits an in vivo level of activity similar to the hypotensive clinical drug captopril should still be stressed, as well as griffithsin which showed such stunning results over a variety of animal models and which will probably move onto clinical trials soon. Regarding clinical trials, studies with pure algal metabolites are scarce, limited to those carried out with kahalalide F and fucoxanthin. The majority of clinical trials currently aim to ascertain the effect of algae consumption, as extracts or fractions, on obesity and diabetes.Studies focusing on the preparation of macroalgae extracts and their chemical characterization revealed a large range of seaweed compounds with very interesting biological activities including antitumor, anti-inflammatory, antimicrobial, antidiabetic, antivirus, antihypertensive, fat-lowering, and neuroprotective activities [12][13][14][15].The large volume of studies proving the seaweed compound activities in in vitro systems [16][17][18][19] hints the need for further advancements in the knowledge about macroalgae compound efficiency in living systems (in vivo) and their use in the development of pharmaceuticals. In vitro studies are very relevant and yield very important information, but they only represent the first step of a long process, and the results obtained rarely reveal anything about the effects of a compound in vivo, because the responses observed in vitro can be magnified, diminished, or totally different in a more complex and integrated system. In fact, in vivo studies and clinical trials are those which contribute most to truly understanding the real potential of compounds as future pharmaceuticals.In this regard, the present work intends to present insight into the results obtained in the last few years regarding secondary metabolites, such as phlorotannins, halogenated compounds, fucoxanthin, and fucosterol isolated from macroalgae, involved in in vivo studies and clinical trials, identifying the research opportunities and knowledge gaps, to valorize these compounds and their natural resources. The intention is not to present an exhaustive survey of all published works, but rather a selection of authors based on the following criteria: in-depth studies involving pure compounds most characteristic f...

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Protective effect of marine brown algal polyphenols against oxidative stressed zebrafish with high glucose

Abstract: We observed that exposure to phlorotannins, which include 6,6-bieckol, phloroeckol, dieckol and phlorofucofuroeckol isolated from an edible brown alga, Ecklonia cava, significantly inhibited high glucose–induced ROS and cell death.

Cited by 38 publications

References 27 publications

Antioxidant activity, nutritional and physicochemical characteristics, and toxicity of minimally refined brown sugar and other sugars

Antioxidant activity, nutritional and physicochemical characteristics, and toxicity of minimally refined brown sugar and other sugars

Metabolites Unravel Nutraceutical Potential of Edible Seaweeds: An Emerging Source of Functional Food

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

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