Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity

Yılmaz, Seval; Ateşşahín, Ahmet; Şahna, Engin; Karahan, İzzet; Özer, Songül Peltek

doi:10.1016/j.tox.2005.10.015

Cited by 223 publications

(165 citation statements)

References 42 publications

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“…Prior studies showed that the administration of doxorubicin caused an increase in MDA levels, as well as reductions in GSH, SOD and glutathione-S-transferase expression in treated rats compared with a control group. Single injection of doxorubicin increased SOD, MDA, NO and xanthine oxidase and myeloperoxidase expression in kidney tissues in rats at 10 days after administration (50)(51)(52). Previous approaches to reduce doxorubicin or 5-FU related toxicities have centred on the use of antioxidants to minimize the generation of reactive oxygen species.…”

Section: Discussionmentioning

confidence: 99%

Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice

Aikemu

Amat

Yusup

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Abnormal Savda Munziq (ASMq), an Uighur medicine formula commonly used in the treatment of cancer, has been speculated to possess antioxidative and antiproliferative effects, and to regulate immune activity. The present study was designed to systematically elucidate the toxicity-reducing activity of ASMq in mice undergoing combination chemotherapy with doxorubicin and 5-fluorouracil (5-FU). The mice were divided into normal (saline, 10 ml/kg) and doxorubicin + 5-FU groups (doxorubicin, 2.5 mg/kg; 5-FU, 10 mg/kg on alternate days). In addition, three groups received different doses of ASMq (2, 4 and 8 g/kg), in addition to doxorubicin (2.5 mg/kg) and 5-FU (10 mg/kg) treatment on alternate days. The histology of the heart and liver, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, malondialdehyde (MDA) concentrations in heart homogenate, and various biochemical parameters of the liver were evaluated. Compared with the normal control group, ASMq dose-dependently improved a number of variables, including body weight, liver index, transaminase and total protein, and partially normalized liver and cardiac pathology. ASMq restored activities of defense antioxidant enzymes SOD and GSH-Px towards normal levels, and decreased MDA concentration in dose-dependent manner. These results demonstrated that ASMq provides significant protection against doxorubicin + 5-FU combination induced hepatotoxicity and cardiotoxicity. Further studies are required to determine the effects of ASMq against doxorubicin + 5-FU-induced toxicity during chemotherapy in vivo.

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Section: Discussionmentioning

confidence: 99%

Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice

Aikemu

Amat

Yusup

et al. 2016

Experimental and Therapeutic Medicine

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“…The protective effect of lycopene against chemotherapy agent toxicities such as cisplatin-induced nephrotoxicity, doxorubicin-induced myocardial or kidney toxicity, gentamycin-induced nephrotoxicity, and oxidative stress was shown in animal studies (20)(21)(22).…”

Section: Discussionmentioning

confidence: 97%

The effect of lycopene on the ototoxicity induced by cisplatin*

Çiçek¹,

Kalcıoğlu²,

Bayındır³

et al. 2014

Turk J Med Sci

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“…The H22 tumor-bearing Kunming mice were randomly divided into three groups (five mice per group) with the equivalent average starting tumor size (~70 mm 3 ) and body weight (~23 g). ATF-HSA:DOX (600 μM in saline) or DOX (600 μM in saline) was injected into mice via caudal veins at a dosage of 5 μmol/kg.…”

Section: In Vitro Cytotoxicity Of Atf-hsa:doxmentioning

confidence: 99%

“…1 Despite its effectiveness and broad clinical indications, DOX is also known for its severe side effects, including hepatotoxicity, 2 cardiotoxicity, and nephrotoxicity. 3 Especially, cardiotoxicity is identified as the most life-threatening adverse effect that may cause the loss of myofibrils and the vacuolization of myocardial cells and, in some cases, congestive heart failure. 4 Various approaches to minimize this side effect of DOX and increase its therapeutic window have been attempted.…”

Section: Introductionmentioning

confidence: 99%

Dual actions of albumin packaging and tumor targeting enhance the antitumor efficacy and reduce the cardiotoxicity of doxorubicin in vivo

Zheng¹,

Li²,

Zhou³

et al. 2015

IJN

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Doxorubicin (DOX) is an effective chemotherapy drug used to treat different types of cancers. However, DOX has severe side effects, especially life-threatening cardiotoxicity. We herein report a new approach to reduce the toxicity of DOX by embedding DOX inside human serum albumin (HSA). HSA is further fused by a molecular biology technique with a tumor-targeting agent, amino-terminal fragment of urokinase (ATF). ATF binds with a high affinity to urokinase receptor, which is a cell-surface receptor overexpressed in many types of tumors. The as-prepared macromolecule complex (ATF–HSA:DOX) was not as cytotoxic as free DOX to cells in vitro, and was mainly localized in cell cytosol in contrast to DOX that was localized in cell nuclei. However, in tumor-bearing mice, ATF–HSA:DOX was demonstrated to have an enhanced tumor-targeting and antitumor efficacy compared with free DOX. More importantly, histopathological examinations of the hearts from the mice treated with ATF–HSA:DOX showed a significantly reduced cardiotoxicity compared with hearts from mice treated with free DOX. These results demonstrate the feasibility of this approach in reducing the cardiotoxicity of DOX while strengthening its antitumor efficacy. Such a tumor-targeted albumin packaging strategy can also be applied to other antitumor drugs.

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Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity

Cited by 223 publications

References 42 publications

Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice

Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice

The effect of lycopene on the ototoxicity induced by cisplatin*

Dual actions of albumin packaging and tumor targeting enhance the antitumor efficacy and reduce the cardiotoxicity of doxorubicin in vivo

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