Protective effect of lutein after ischemia-reperfusion in the small intestine

Sato, Yuki; Kobayashi, Masaki; Itagaki, Shirou; Hirano, Takeshi; Noda, Toshihiro; Mizuno, Satoshi; Sugawara, Mitsuru; Iseki, Ken

doi:10.1016/j.foodchem.2011.01.096

Cited by 22 publications

(16 citation statements)

References 29 publications

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“…Lutein-induced antiinflammation has been reported against atherosclerosis, UVdamage induced skin-inflammation, LPS inflammation in macrophages [10][11][12] . Further protective role of Lutein against small intestine 13 and kidney 14 ischemic injury has been reported recently. This study examines the role of Lutein against skeletal muscle injury and aims at exploring important mediators involved in oxidative stress and inflammation and aims at determining the potential role of Lutein against skeletal IR injury.…”

Section: Introductionmentioning

confidence: 78%

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Lutein protects against ischemia/reperfusion injury in rat skeletal muscle by modulating oxidative stress and inflammation

Fang

Zhang

Yan

et al. 2015

Immunopharmacology and Immunotoxicology

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Section: Introductionmentioning

confidence: 78%

“…injection 1 h before the reperfusion. The dose of Lutein was fixed based on the study 14 . The study included Lutein as a separate group (animals received Lutein (0.5 mg/kg i.p) alone) (data not shown).…”

Section: Animals and Skeletal Muscle Ir Injurymentioning

confidence: 99%

Lutein protects against ischemia/reperfusion injury in rat skeletal muscle by modulating oxidative stress and inflammation

Fang

Zhang

Yan

et al. 2015

Immunopharmacology and Immunotoxicology

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“…We have already reported that other antioxidants exhibit antioxidant ac-tivities and attenuate intestinal I/R injury. 23,36,41) Reperfusion of the ischemic intestine results in an increase in vascular permeability to Evans blue dye (Fig. 4).…”

Section: Discussionmentioning

confidence: 99%

“…For the prevention of these diseases, an approach focusing on the health aspects of natural antioxidants should be beneficial. 23,36,37,41) In order to develop new functional foods, it is important to select a suitable ingredient that has a scientific background. The results of this study should provide a scientific background of the usefulness of genistein as a functional food ingredient.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Sato

Itagaki

Oikawa

et al. 2011

Biological & Pharmaceutical Bulletin

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Ischemia-reperfusion (I/R) injury of the intestine is an important factor associated with high rates of morbidity and mortality. Intestinal I/R is a common clinical problem in the settings of severe burns, circulatory shock and strangulation ileus. Intestinal I/R damages remote organs and promotes multi-organ failure. It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R. In that study, the authors used a standard complex enteral diet and they suggested that it is important to find new nutrient formulas. Since reactive oxygen species are responsible for intestinal I/R injury, we focused on a dietary polyphenol, the soy isoflavone genistein. Genistein has a wide spectrum of biochemical and pharmacological activities. However, the possibility of a protective effect of genistein as enteral nutrition on I/R injury has not been investigated. We therefore investigated the protective effect of genistein on oxidative injury using intestinal I/R model rats. We found that genistein, which has combined antioxidant activity from radical scavenging, xanthine oxidase inhibition and chain-breaking effects, exhibits a protective effect on intestinal I/R injury. The results suggest that genistein, a soy isoflavone, has the possibility as a new nutrient formula of enteral feeding.

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“…injection of 50 mg/kg sodium pentobarbital. 14) To determine the effect of bile on absorption after oral administration, the rats were divided into two groups: a sham group (control), in which a small midline incision was made in the abdomen, and a bile duct-ligated group, in which the bile duct was ligated by suturing. Bile was collected from other rats by biliary cannula (PE-10).…”

Section: Methodsmentioning

confidence: 99%

Emulsification Using Highly Hydrophilic Surfactants Improves the Absorption of Orally Administered Coenzyme Q10

Sato

Mutoh

Suzuki

et al. 2013

Biological & Pharmaceutical Bulletin

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Coenzyme Q10 (CoQ10) is an essential component in the electron-transport systems of mitochondria and bacteria and is often used as a supplementary treatment for some diseases. We previously reported that the bioavailability of CoQ10 powder was less than 10%. In this study, we investigated various preparations to improve the intestinal absorption of CoQ10 with focus on the effect of emulsification. We prepared a suspension and some emulsions with four types of surfactants and investigated the plasma concentration profile after oral administration to rats. The absorption of CoQ10 was improved by an emulsion formulation although there was little absorption of CoQ10 when a suspension was administered. However, little CoQ10 was absorbed in the bile duct-ligated group even when the emulsion formulation was administered (about 50% of the control group). Bile and emulsion formulation are essential for absorption of CoQ10. When the preparations containing Tween20 (polysorbate (20) sorbitan monolaurate) and Tween80 (polyoxyethylene (20) sorbitan monooleate) were administered, plasma concentrations of CoQ10 were higher than those obtained with preparations containing Tween65 (polyoxyethylene (20) sorbitan tristearate) and Span20 (sorbitan monolaurate). Tween20 and Tween80 have higher hydrophile-lipophile balance (HLB) values than those Tween65 and Span20. Our study suggests that highly lipophilic compounds like CoQ10 would diffuse the unstirred water layer and would easily access the intestinal apical membrane by an emulsion containing a surfactant with a high HLB value. Attention must be given to CoQ10 supplementation for patients whose bile is not excreted to the intestine such as patients with cholestasis.Key words coenzyme Q10; absorption; bile; emulsion; intestine; lutein Preventive medicine and anti-aging medicine have received much attention recently due to increases in the proportion of elderly people in the population and patients with lifestyle diseases such as hypertension, dislipidemia and diabetes. Oxidative stress is involved in the onset of lifestyle diseases, 1,2) and various antioxidant supplements and antioxidant-fortified functional foods have recently become available. Many epidemiological studies have shown relationships between consumption of polyphenol or carotenoid-rich foods and prevention of these lifestyle diseases. 3,4) Coenzyme Q (CoQ) has a benzoquinone ring linked to a polyisoprenyl chain of 9 or 10 units in mammalian species. CoQ10, also known as ubiquinone, is a ubiquitous component vital to a number of activities related to energy metabolism. CoQ10 also functions in its reduced form as an antioxidant, protecting biological membranes and serum low density lipoprotein (LDL) from lipid peroxidation. 5,6) The use of CoQ10 as a therapeutic cardiovascular agent was based on its fundamental role in mitochondrial function and cellular bioenergetics. 7,8) Many studies have also indicated a beneficial antioxidant effect of CoQ10 as supplementation, and CoQ10 has received much attention due to its an...

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Protective effect of lutein after ischemia-reperfusion in the small intestine

Cited by 22 publications

References 29 publications

Lutein protects against ischemia/reperfusion injury in rat skeletal muscle by modulating oxidative stress and inflammation

Lutein protects against ischemia/reperfusion injury in rat skeletal muscle by modulating oxidative stress and inflammation

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Emulsification Using Highly Hydrophilic Surfactants Improves the Absorption of Orally Administered Coenzyme Q10

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