Protective effect of low molecular fraction of MGN-3, a modified arabinoxylan from rice bran, on acute liver injury by inhibition of NF-κB and JNK/MAPK expression

Zheng, Surina; Sugita, Shunsuke; Hirai, Shizuka; Egashira, Yukari

doi:10.1016/j.intimp.2012.10.012

Cited by 23 publications

(19 citation statements)

References 51 publications

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“…In this study, GalN-induced hepatitis model has been selected because of its similar morphological and pathophysiological characteristics to those of human hepatitis B [112]. The same group reported that the hepatoprotective efficacy of MGN-3 is mediated via inhibition of nuclear factor-κB (NF-κB) and JNK/MAPK expression in the liver of GalN-induced rats [113]. In 2016, Salama et al [114] reported the suppressive effect of rice bran AX (Biobran) on the viremia level in patients with chronic hepatitis C virus (HCV) infection.…”

Section: Hepatoprotective Effect Of Axsmentioning

confidence: 99%

Health-related effects and improving extractability of cereal arabinoxylans

Fadel

Mahmoud

Ashworth

et al. 2018

International Journal of Biological Macromolecules

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Arabinoxylans (AXs) are major dietary fibers. They are composed of backbone chains of β-(1-4)-linked xylose residues to which α-l-arabinose are linked in the second and/or third carbon positions. Recently, AXs have attracted a great deal of attention because of their biological activities such as their immunomodulatory potential. Extraction of AXs has some difficulties; therefore, various methods have been used to increase the extractability of AXs with varying degrees of success, such as alkaline, enzymatic, mechanical extraction. However, some of these treatments have been reported to be either expensive, such as enzymatic treatments, or produce hazardous wastes and are non-environmentally friendly, such as alkaline treatments. On the other hand, mechanical assisted extraction, especially extrusion cooking, is an innovative pre-treatment that has been used to increase the solubility of AXs. The aim of the current review article is to point out the health-related effects and to discuss the current research on the extraction methods of AXs.

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Section: Hepatoprotective Effect Of Axsmentioning

confidence: 99%

Health-related effects and improving extractability of cereal arabinoxylans

Fadel

Mahmoud

Ashworth

et al. 2018

International Journal of Biological Macromolecules

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“…In macrophages stimulated by LPS, ferulated oligosaccharides have suppressed the production of tumor necrosis factor-α (TNF-α), interleukin-1α (IL-1α), IL-6, nitric oxide (NO), and prostaglandin E2 (PGE2) (Fang, Chen et al 2012). A low molecular fraction of the MGN-3 polysaccharide, an enzymatically-modified bran arabinoxylan, tested on a rat model of acute liver injury, has been found to exert protective effects due to the inhibition of NF-κB and JNK MAP kinase expression (Zheng, Sugita et al 2012). …”

Section: Antinflammatory Effectsmentioning

confidence: 99%

Therapeutic properties of rice constituents and derivatives (Oryza sativa L.): A review update

Burlando¹,

Cornara²

2014

Trends in Food Science & Technology

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“…Nutritional optimization through dietary supplementation may offer an alternative treatment strategy for NAFLD. Many studies have shown that a potent hydrolyzed polysaccharide, Rice Bran Arabinoxylan Compound (RBAC), possesses a biologic response modifier effect on immune system function, particularly natural killer (NK) cell activity [9][10][11][12][13][14][15]. For example, two separate rat studies have demonstrated the effectiveness of RBAC on various biomarkers after d-galactosamine-(Ga1N-) induced acute liver disease, which is essentially a model of hepatitis in humans [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…e protective mechanism was mediated in part by downregulation of interleukin-18 (IL-18) in the first study [9]. e second study showed that nuclear factor-κB (NF-κB) and CD14+ were involved in the suppressive action of RBAC on GalN-induced hepatitis [10].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, GalN-induced inhibitor of κB kinase degradation appeared to be prevented by RBAC, and associated suppression of NF-κB activation was noted. Additionally, RBAC significantly inhibited CD14+ mRNA expression [10]. RBAC is also likely to possess antioxidant capabilities, as it has been shown to enhance macrophage phagocytic activity and nitric oxide release and scavenge free radicals in a dose-dependent manner [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Corrigendum to “The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease”

Lewis

Atlas

Higuera

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The primary objective of the study was to evaluate the effect of a hydrolyzed polysaccharide, Rice Bran Arabinoxylan Compound (RBAC), on biomarkers in adults with nonalcoholic fatty liver disease (NAFLD). A 90-day randomized double-blind placebo-controlled trial examined the effect of RBAC on complete blood count, liver enzymes, lipids, oxidative stress markers, cytokines, and growth factors. Twenty-three adults with NAFLD were enrolled and randomly assigned to one of the two study conditions (n = 12 RBAC and n = 11 placebo) and consumed 1 gram/day of either compound for 90 days. Subjects were assessed at baseline and 45 and 90 days. No adverse effects were reported. Alkaline phosphatase significantly decreased (−3.1%; SD = 19.9; F[1, 19] = 5.1, p=0.03) in the RBAC group compared to placebo. Percent monocytes (17.9%; SD = 18.3; F[1, 19] = 5.9, p=0.02) and percent eosinophils (30.6%; SD = 30.5; F[1, 19] = 12.3, p<0.01) increased in the RBAC group. IFN-γ (156%; SD = 131.8; F[1, 19] = 4.2, p=0.06) and IL-18 (29.1%; SD = 64; F[1, 19] = 5.3, p=0.03) increased in the RBAC group compared to placebo. Other improvements were noted for platelets, neutrophils, neutrophil-lymphocyte ratio, γ-glutamyl transferase, and 4-hydroxynonenal. RBAC had beneficial effects on several biomarkers that add to the known immunomodulatory activities of RBAC, which may be promising for people with NAFLD. This trial is registered with NCT02568787.

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Protective effect of low molecular fraction of MGN-3, a modified arabinoxylan from rice bran, on acute liver injury by inhibition of NF-κB and JNK/MAPK expression

Cited by 23 publications

References 51 publications

Health-related effects and improving extractability of cereal arabinoxylans

Health-related effects and improving extractability of cereal arabinoxylans

Therapeutic properties of rice constituents and derivatives (Oryza sativa L.): A review update

Corrigendum to “The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease”

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