Protective effect of low-intensity transcranial ultrasound stimulation after differing delay following an acute ischemic stroke

Liu, Lanxiang; Du, Juan; Zheng, Tao; Hu, Shuo; Dong, Yanchao; Du, Dan; Wu, Shuo; Wang, Xuemei; Shi, Qinglei

doi:10.1016/j.brainresbull.2018.12.004

Cited by 25 publications

(14 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transcranial Focused Ultrasound Stimulation is a non-invasive neuromodulation technique, regulating the human somatosensory cortex ( Lee et al, 2016 ). tFUS contributes to protection against ischemic brain damage ( Li et al, 2017 ; Liu et al, 2019a ; Wu et al, 2020 ). Recently, it is reported that ultrasound stimulation of the brain can modulate microglial polarization toward the anti-inflammatory phenotype, upregulate IL-10R and IL-10, and promote neurorehabilitation following stroke ( Wang et al, 2021 ).…”

Section: Microglia-based Treatment Targeting Post-stroke Neuroplasticitymentioning

confidence: 99%

New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery

Huang

Ran

et al. 2021

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Stroke remains the leading cause of long-term disability worldwide with significant long-term sequelae. However, there is no highly effective treatment to enhance post-stroke recovery despite extensive efforts in exploring rehabilitative therapies. Neurorehabilitation is recognized as the cornerstone of functional restoration therapy in stroke, where treatments are focused on neuroplastic regulation to reverse neural structural disruption and improve neurofunctional networks. Post-stroke neuroplasticity changes begin within hours of symptom onset and reaches a plateau by 3 to 4 weeks within the global brain in animal studies. It plays a determining role in spontaneous stroke recovery. Microglia are immediately activated following cerebral ischemia, which has been found both proximal to the primary ischemic injury and at the remote brain regions which have functional connections to the primary injury area. Microglia exhibit different activation profiles based on the microenvironment and adaptively switch their phenotypes in a spatiotemporal manner in response to brain injuries. Microglial activation coincides with neuroplasticity after stroke, which provides the fundamental base for the microglia-mediated inflammatory responses involved in the entire neural network rewiring and brain repair. Microglial activation exerts important effects on spontaneous recovery after stroke, including structural and functional reestablishment of neurovascular networks, neurogenesis, axonal remodeling, and blood vessel regeneration. In this review, we focus on the crosstalk between microglial activation and endogenous neuroplasticity, with a special focus on the plastic alterations in the whole brain network and their implications for structural and functional restoration after stroke. We then summarize recent advances in the impacts of microglial phenotype polarization on brain plasticity, trying to discuss the potential efficacy of microglia-based extrinsic restorative interventions in promoting post-stroke recovery.

show abstract

Section: Microglia-based Treatment Targeting Post-stroke Neuroplasticitymentioning

confidence: 99%

New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery

Huang

Ran

et al. 2021

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The ultrasonic stimulation system and parameters are the same as our previous studies (18). In the LITUS system, two generators (AFG3022C; Tektronix, USA) were used to generate the pulse signal.…”

Section: Litus Protocolmentioning

confidence: 99%

Effect of Low Intensity Transcranial Ultrasound (LITUS) on Post-traumatic Brain Edema in Rats: Evaluation by Isotropic 3-Dimensional T2 and Multi-TE T2 Weighted MRI

Zheng

Yuan

et al. 2020

Front. Neurol.

Self Cite

View full text Add to dashboard Cite

Background: Brain edema is one of the important factors affecting the prognosis of traumatic brain injury (TBI). Low-intensity transcranial ultrasound (LITUS) has significant anti-cerebral edema effect. T2-weighted image-based volume and T2 value measurements can sensitively reflect tissue edema. Purpose: To evaluate the effect and possible mechanisms of LITUS on brain edema by iso-voxel 3-dimensional T2WI (iso-3D T2WI) and multi-TE T2WI. Methods: Forty-five rats were randomly divided into sham control, TBI and TBI + LITUS groups ( n = 15, respectively). Iso-voxel 3-dimensional T2WI and multi-TE T2WI sequences at 3.0T to obtain T2 value and edema volume of the injury cortex. T2 values were obtained on days 1, 7, 14, 21, 28, 35, and 42 after TBI and brain edema volume were obtained on days 7 and 14. Results: The T2 values of the damaged cortex in the TBI group showed a slow decreasing trend after a significant increase. For TBI+LITUS group, T2 values decreased with continuous LITUS treatment. At day 28, the T2 values were not significantly longer than the control group (adjusted P = 0.0535), but were significantly shorter than the TBI group at day 42 (adjusted P = 0.0003). The edema volume at day 7 and 14 in the LITUS group was significantly lower than the TBI group ( P = 0.0004 and P < 0.0001, respectively). AQP-4 and β-APP protein staining showed a strong positive reaction near the CCI point, TBI+LITUS group showed a medium positive reaction, and the sham control group showed a weak positive reaction. Conclusion: The therapeutic effect of LITUS on post-traumatic brain edema was confirmed through T2 value and edema volume, and the mechanism may be related to inhibiting the expression of AQP-4 and promoting the removal of β-APP.

show abstract

“…Particularly, it is ambiguous that how rTMS with different intensities, at different frequencies, can modulate the neural circuit activities, such as the neural plasticity which is one of the most important characters of the neural function, because of the limitation of animal models. Cultured neurons [10,11] and hippocampal slices [12] from rats and even humans [13,14] have been utilized to study the role of rTMS. However, these models are difficult to present a complete loop neural circuit.…”

Section: Introductionmentioning

confidence: 99%

Cellular Mechanism Underlying rTMS Treatment for the Neural Plasticity of Nervous System in Drosophila Brain

Luo

Yang

Wang

et al. 2019

IJMS

View full text Add to dashboard Cite

Repetitive transcranial magnetic stimulation (rTMS) is used as a research tool and clinical treatment for the non-clinical and clinical populations, to modulate brain plasticity. In the case of neurologic and psychiatric disease, there is significant evidence to suggest that rTMS plays an important role in the functional recovery after neurological dysfunction. However, the causal role for rTMS in the recovery of nervous dysfunction remains unclear. The purpose of the present study is to detect the regulation of rTMS on the excitatory neuronal transmission and specify the mode of action of rTMS on the neural plasticity using Drosophila whole brain. Therefore, we identified the effects of rTMS on the neural plasticity of central neural system (CNS) by detecting the electrophysiology properties of projection neurons (PNs) from adult Drosophila brain after rTMS. Using patch clamp recordings, we recorded the mini excitatory postsynaptic current (mEPSC) of PNs after rTMS at varying frequencies (1 Hz and 100 Hz) and intensities (1%, 10%, 50%, and 100%). Then, the chronic electrophysiology recordings, including mEPSC, spontaneous action potential (sAP), and calcium channel currents from PNs after rTMS at low frequency (1 Hz), with low intensity (1%) were detected and the properties of the recordings were analyzed. Finally, the frequency and decay time of mEPSC, the resting potential and frequency of sAP, and the current density and rise time of calcium channel currents were significantly changed by rTMS. Our work reveals that rTMS can be used as a tool to regulate the presynaptic function of neural circuit, by modulating the calcium channel in a frequency-, intensity- and time-dependent manner.

show abstract

Protective effect of low-intensity transcranial ultrasound stimulation after differing delay following an acute ischemic stroke

Cited by 25 publications

References 23 publications

New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery

New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery

Effect of Low Intensity Transcranial Ultrasound (LITUS) on Post-traumatic Brain Edema in Rats: Evaluation by Isotropic 3-Dimensional T2 and Multi-TE T2 Weighted MRI

Cellular Mechanism Underlying rTMS Treatment for the Neural Plasticity of Nervous System in Drosophila Brain

Contact Info

Product

Resources

About