Protective effect of Lizhong Pill on nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rats: Possible involvement of TNF and IL-17 signaling pathways

Yu, Chang; Qiu, Jingyue; Xiong, Meng; Bao-ping, Ren; Zhong, Meiqi; Zhou, Shengzhen; Li, Yuejun; Zeng, Meiyan; Song, Haixing

doi:10.1016/j.jep.2023.116991

Cited by 2 publications

(2 citation statements)

References 63 publications

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“…Traditional Chinese medicines (TCMs) have been used to treat gastrointestinal disorders for thousands of years. TCM has attracted considerable attention in modern times because of its remarkable therapeutic effects, mild efficacy, and minimal side effects [7]. As a TCM prescription, Gancao Xiexin Decoction (GCXXD) was originally published in ‘Treatise on Febrile and Miscellaneous Disease.’ The prescriptions included Glycyrrhizae Radix et Rhizoma (GR), Scutellariae Radix (SR), Zingiberis Rhizoma (ZR), Pinelliae Rhizoma (PR), Jujubae Fructus (JF), and Coptidis Rhizoma (CR).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Integrated ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry‐based components analysis and network pharmacology strategy of Gancao Xiexin Decoction in treating gastric ulcer

Wang,

Tang,

Huang

et al. 2024

J of Separation Science

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Gancao Xiexin Decoction (GCXXD) is a traditional Chinese decoction that is often used in treating gastric ulcers. However, the substance basis and mechanism of action remain unclear. In this study, in vivo and in vitro components of GCXXD were analyzed by ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry. The compound Discover platform was used to ultimately enable rapid identification of compounds. Acquire X intelligent data acquisition technology software was innovatively adopted. In the process of collecting drug‐containing plasma, all components detected in blank plasma samples were excluded to eliminate the interference and influence of endogenous components in plasma, making the analysis results more accurate and reliable. At the same time, the possibility of selecting precursor parent ions with low concentration levels within the chromatographic peak can be increased, improving the coverage and integrality of the detection of components in vivo. Also, the targeted network pharmacology strategy combined with molecular docking was established to explore the mechanism of GCXXD in treating gastric ulcers. As a result, 113 components were identified, 41 of which could enter the bloodstream and exert therapeutic effects in vivo. The main effective components are glycyrrhizic acid, 6‐gingerol, jatrorrhizine, wogonin, palmatine, and liquiritigenin, main targets in vivo were related to ALB, IL6, and VEGF, which play an important role in anti‐inflammatory and promoting angiogenesis. In summary, this study adopted a comprehensive analysis strategy to reveal the pharmacodynamic material basis and mechanism of GCXXD against gastric ulcers, providing a scientific basis for its clinical application.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integrated ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry‐based components analysis and network pharmacology strategy of Gancao Xiexin Decoction in treating gastric ulcer

Wang,

Tang,

Huang

et al. 2024

J of Separation Science

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A Study on the Correlation between SLC25A26 Polymorphism and Gastritis and Gastric Ulcers in Koreans

PARK,

HWANG

2023

Korean J Clin Lab Sci

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Gastritis is an inflammation of the gastric mucosa and gastric ulcers are a break in the mucosa of the stomach lining. Past research on gastritis and gastric ulcers has been mainly conducted from the perspective that environmental factors are the primary cause of these gastric diseases. However, recently the importance of genetic factors has been emphasized due to current developments in genetic research. The SLC25A26 gene is believed to be associated with the accumulation of reactive oxygen species. Oxidative stress promotes an inflammatory response, which increases the production of free radicals and causes cellular damage, and these lead to the development of gastric diseases.In this study, the correlation between SLC25A26 and gastric diseases was analyzed. Polymorphisms in SLC25A26 were analyzed in 1,369 domestic gastric disease patients and 7,471 healthy controls.As a result, 11 single nucleotide polymorphisms (SNPs) (in the genotype) and 13 SNPs (in the imputation) showed statistical significance (P＜0.05), and high relative risk of gastric diseases.Among them, the rs13874 allele of SLC25A26 showed a highly significant association with gastric diseases. In the genotype-based mRNA expression analysis, the minor allele (C) group showed increased mRNA expression and this could increase oxidative stress. In conclusion, SLC25A26 polymorphisms are associated with gastric diseases. These results may provide a basis for new guidelines for gastric disease management in the Korean population.

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Protective effect of Lizhong Pill on nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rats: Possible involvement of TNF and IL-17 signaling pathways

Cited by 2 publications

References 63 publications

Integrated ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry‐based components analysis and network pharmacology strategy of Gancao Xiexin Decoction in treating gastric ulcer

Integrated ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry‐based components analysis and network pharmacology strategy of Gancao Xiexin Decoction in treating gastric ulcer

A Study on the Correlation between SLC25A26 Polymorphism and Gastritis and Gastric Ulcers in Koreans

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