Protective effect of Lespedeza cuneata ethanol extract on Bisphenol A-induced testicular dysfunction in vivo and in vitro

Park, Bong‐Kyun; Kwon, Jeong Eun; Cho, Se Min; Kim, Chang Won; Lee, Da Eun; Koo, Young Tae; Lee, Hyun Myung; Kang, Se Chan

doi:10.1016/j.biopha.2018.03.045

Cited by 16 publications

(34 citation statements)

References 52 publications

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“…To use as a model for human testicular dysgenesis syndrome, pregnant rats were exposed to DnBP and a suppression of intratesticular testosterone, a focal aggregation of Leyding cells and ectopic Sertoli cells were obtained [27]. Also, the possible molecular mechanism of MnBP was investigated in vitro and even at low dose, an increased Sertoli cells proliferation emerged [28].Among other chemicals, evidence from previous studies showed that also bisphenol A (BPA), a precursor to important plastics like polycarbonates and epoxy resins, could interact with the endocrine system [29,30] and semen quality as well [31,32] even if the present evidence is controversial.According to Lassen et al [33] the association between BPA levels and reproductive hormones would support an anti-androgenic effect with deleterious consequences on motile spermatozoa (−6.7%, confidence interval-CI −11.76/1.63 95%), data confirmed also by Radwan et al [34].BPA induced, in in vivo studies, testicular dysfunction and alteration of Sertoli cell viability [35], testicular apoptosis in male rats [36]; after BPA exposure spermatogenic cells were disorganized and degenerated, spermatids had fragmented pyknotic nuclei and a significant decrease in the rate of proliferation of germ cells was present [37].In an epidemiological survey on 215 young health adults, the urinary BPA levels were significantly and inversely associated with sperm concentration and total sperm count [38]. In recent surveys [39,40] sperm concentration, morphology and motility were negatively associated with BPA urinary levels.…”

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confidence: 59%

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Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Caporossi

Alteri

Campo

et al. 2020

IJERPH

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Among the possible risk factors for male reproduction, exposure to phthalates and alkylphenols is widely documented. This study evaluated the possible association between chemical exposure and the quality of the seminal fluid of 105 subjects in a fertility clinic. The urinary levels of seven phthalate metabolites (monoethylphthalate, MEP; monobenzylphthalate, MBzP; mono n-butylphthalate, MnBP; mono-(2-ethylhexyl) phthalate, MEHP; mono(2-ethyl-5-hydroxyhexyl) phthalate, MEHHP; mono-n-octylphthalate, MnOP; mono-isononylphthalate, MiNP) and bisphenol A (BPA), were analysed by high performance liquid chromatography/tandem mass spectrometry HPLC/MS/MS. The regression analysis showed that the semen volume was positively associated with MnBP, MnOP and BPA levels while was negatively associated with MiNP levels. The sperm concentration had a significant inverse relationship with MEP levels. A negative association was found between the use of plastic containers for food storage (p = 0.037) and semen volume (3.06 vs. 2.30 mL as average values, never vs daily). A significant positive correlation emerged (p < 0.005) between the consumption of canned food and the levels of BPA (2.81 vs. 0.14 µg/g creat as average values, daily vs. never) and between the use of perfumes and levels of MEP (389.86 vs. 48.68 µg/g creat, as average values, daily vs. never). No further statistically significant associations were found, even considering the working activity. Some evidence emerged about the possible link between exposure and seminal fluid quality: further case/control or prospective studies will allow us to confirm this causality hypothesis.

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confidence: 59%

“…BPA induced, in in vivo studies, testicular dysfunction and alteration of Sertoli cell viability [35], testicular apoptosis in male rats [36]; after BPA exposure spermatogenic cells were disorganized and degenerated, spermatids had fragmented pyknotic nuclei and a significant decrease in the rate of proliferation of germ cells was present [37].…”

mentioning

confidence: 98%

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Caporossi

Alteri

Campo

et al. 2020

IJERPH

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“…In another study about postnatal exposure to BPA, it was shown that administering different doses of BPA (0, 20 and 40 µg kg-1 day -1) from postnatal Day (PND) 3 to PND21, PND 35 or PND49 effected the meiotic process of germ cells and spermatogenesis (43). In additional, a significant increase in DNA damage to spermatocytes and decrease sperm count and motility was observed, following 12 weeks of BPA (10mg/kg bwt) administration in mice (44). Smilarly, Rahman et al (2017) reported that, toxic effect of gestational BPA exposure (5 mg/kg, and 50 mg/kg bw/day) on motility, capacitation, and motion kinematics of spermatozoa in mice.…”

Section: Bpa Spermatogenesis and Sperm Qualitymentioning

confidence: 98%

Bisphenol A and Male Reproductive System

Amraje¹,

Köylü²,

Dizakar³

et al. 2018

GMJ

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Bisphenol A (BPA) is an alkylphenol endocrine disruptor chemical (EDC). It is a building block for polycarbonate (PC) plastics and epoxy resins and it is used in food packaging, canned foods, baby bottles, baby food jars and medical devices. Recently, researchers have shown an increased interest in BPA and its effect on reproduction, neurodevelopment and metabolism. The experimental data are rather controversial, and there is no general consensus about BPA's effects. In this review, potential impacts of the BPA on male reproductive system in prenatal and postnatal period are summarized.

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“…Oral administration of ethanol extract of L. cuneata in BPA-exposed male mice restored testis weight, sperm count, motility, and testosterone levels; inhibited serum biomarkers and oxidative stress defences such as total cholesterol, triglycerides, HDL/LDL-cholesterol, glucose, FFAs, hs-CRP, angiotensinogen, angiotensin II, GOT, GPT, TBARS, GSH, CAT, and SOD1. In vitro , L. cuneata extract recovered cell viability in BPA-treated TM4 Sertoli cells by attenuating Bax expression and activating caspase 3 and PARP [ 112 ].…”

Section: Bpa and Nutraceuticals: Simultaneous Health Effectsmentioning

confidence: 99%

BPA and Nutraceuticals, Simultaneous Effects on Endocrine Functions

D’Angelo

Scafuro

Meccariello

2019

EMIDDT

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Background: Bisphenol A (BPA) is worldwide diffused as a monomer of epoxy resins and polycarbonate plastics and has recognized activity as Endocrine Disruptor (ED). It is capable to interfere or compete with endogenous hormones in many physiological activities thus having adverse outcomes on health. Diet highly affects health status and in addition to macronutrients, provides a large number of substances with recognized pro-heath activity, and thus called nutraceuticals. Objective: This mini-review aims at summarizing the possible opposite and simultaneous effects of BPA and nutraceuticals on endocrine functions. The possibility that diet may represent the first instrument to preserve health status against BPA damages has been discussed. Methods: The screening of recent literature in the field has been carried out. Results: The therapeutic and anti-oxidant properties of many nutraceuticals may reverse the adverse health effects of BPA. Conclusion: In vitro and in vivo studies provided evidence that nutraceuticals can preserve the health. Thus, the use of nutraceuticals can be considered a support for clinical treatment. In conclusion, dietary remediation may represent a successful therapeutic approach to maintain and preserve health against BPA damage.

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Protective effect of Lespedeza cuneata ethanol extract on Bisphenol A-induced testicular dysfunction in vivo and in vitro

Cited by 16 publications

References 52 publications

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Bisphenol A and Male Reproductive System

BPA and Nutraceuticals, Simultaneous Effects on Endocrine Functions

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