Protective effect of leg fat against cardiovascular risk factors in obese premenopausal women

Faloia, Emanuela; Tirabassi, Giacomo; Canibus, Paola; Boscaro, Marco

doi:10.1016/j.numecd.2008.02.004

Cited by 25 publications

(16 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in direct contrast to the hypothesis that gluteo‐femoral SAT secretes less pro‐inflammatory cytokines compared with abdominal SAT 9 . Accumulation of gluteal SAT has been regarded as protective, with some, 2,9 but not all, 29,30 studies showing a positive association between increasing hip circumference and/or leg fat mass and favourable metabolic risk profiles.…”

Section: Discussionmentioning

confidence: 84%

Depot‐ and ethnic‐specific differences in the relationship between adipose tissue inflammation and insulin sensitivity

Evans

Goedecke

Söderström

et al. 2010

Clinical Endocrinology

View full text Add to dashboard Cite

Black South African women had higher inflammatory gene expression levels than white women; however, the relationship between AT inflammation and S(I) was stronger in white compared to black women. Further research is required to explore other factors affecting S(I) in black populations. Contrary to our original hypothesis, gluteal SAT had a greater inflammatory gene expression profile than abdominal SAT depots. The protective nature of gluteo-femoral fat therefore requires further investigation.

show abstract

Section: Discussionmentioning

confidence: 84%

Depot‐ and ethnic‐specific differences in the relationship between adipose tissue inflammation and insulin sensitivity

Evans

Goedecke

Söderström

et al. 2010

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…Beyond the implication of TFM, large LFMs were linked up to low triglycerides, LDL cholesterol, and fasting insulin levels, as well as to high HDL cholesterol values in healthy European men and women . LFM was also inversely associated with blood pressure, plasma lipids, and glucose in severely obese premenopausal women , with insulin resistance and dyslipidaemia in postmenopausal older women , with metabolic syndrome and inflammatory markers (CRP, interleukin 6, tumor necrosis factor alpha, and plasminogen activator inhibitor‐1) in obese older adults , and with fasting and 2‐h post‐load glucose levels in old men and women .…”

Section: Discussionmentioning

confidence: 99%

Cardiometabolic risk: leg fat is protective during childhood

et al. 2015

View full text Add to dashboard Cite

Background Childhood obesity is associated with early cardiometabolic risk (CMR), increased risk of adulthood obesity, and worse health outcomes. Leg fat mass (LFM) is protective beyond total fat mass (TFM) in adults. However, the limited evidence in children remains controversial. Objective We investigated the relationship between LFM and CMR factors in youth. Subjects A total of 203 overweight/obese children, 7–17‐yr‐old, followed in the Pediatric Clinic, Luxembourg. Methods TFM and LFM by dual energy x‐ray absorptiometry and a detailed set of CMR markers were analyzed. Results After TFM, age, sex, body mass index (BMI) Z‐score, sexual maturity status, and physical activity adjustments, negative significant partial correlations were shown between LFM and homeostasis model assessment of insulin resistance (HOMA) (variance explained: 6.05% by LFM*; 7.18% by TFM**), fasting insulin (variance explained: 5.71% by LFM*; 6.97% by TFM**), triglycerides (variance explained: 3.96% by LFM*; 2.76% by TFM*), systolic blood pressure (variance explained: 2.68% by LFM*; 4.33% by TFM*), C‐reactive protein (variance explained: 2.31% by LFM*; 4.28% by TFM*), and resistin (variance explained: 2.16% by LFM*; 3.57% by TFM*). Significant positive partial correlations were observed between LFM and high‐density lipoprotein (HDL) cholesterol (variance explained: 4.16% by LFM*) and adiponectin (variance explained: 3.09% by LFM*) (*p‐value < 0.05 and **p‐value < 0.001). In order to adjust for multiple testing, Benjamini–Hochberg method was applied and the adjusted significance level was determined for each analysis. LFM remained significant in the aforementioned models predicting HOMA, fasting insulin, triglycerides, and HDL cholesterol (Benjamini and Hochberg corrected p‐value < 0.01). Conclusions LFM is protective against CMR in children, at least in terms of insulin resistance and adverse blood lipid profiles.

show abstract

“…body Mass Index (BMI), waist and hip circumference, and to evaluate comorbidities and medication prescribed. Body Mass Index (BMI), waist and hip circumference were measured according to standard protocol: BMI was calculated as weight in kilograms divided by the square of the height in metres (kg/m 2 ), and the World Health Organization classification of BMI for adult population was applied: normal weight, 18.5 ≤ BMI < 25.0 kg/m 2 ; overweight, 25.0 ≤ BMI < 30.0 kg/m 2 ; obesity, BMI ≥ 30.0 kg/m 2 [23]. …”

Section: Methodsmentioning

confidence: 99%

Correlates of perceived health related quality of life in obese, overweight and normal weight older adults: an observational study

et al. 2014

Self Cite

View full text Add to dashboard Cite

BackgroundObesity is a complex multifactorial disease, which also has an impact on quality of life. The aim of this paper is to identify the correlates of perceived health related quality of life in obese, overweight and normal weight Italians older adults.Methods205 subjects at the age ≥ 60 yrs. were recruited into the Division of Endocrinology of the Polytechnic University of Marche Region, Ancona (Italy). A protocol of questionnaires was constructed for data collection, and included domains such as physical activity, quality of life, socio-psychological aspects. The association of the latter variables with SF-36 Health Survey physical component (PCS-36) were evaluated in the whole sample. Multiple linear regression models were used to assess the effect of independent variables on PCS-36 and the physical subscales of SF-36.ResultsPCS-36 showed a lower score in the obese and overweight subjects than the normal weight group (post-hoc test, p < 0.001 and p < 0.05 respectively). Age, gender (male), Body Mass Index, years of education, Physical Activity Scale for the Elderly (PASE) total score, Hospital Anxiety and Depression Scale anxiety, Hospital Anxiety and Depression Scale depression, number of medications prescribed and number of diseases were included in the model. Negative and significant PCS-associated variables included depression (p = 0.009), BMI (p = 0.001), age in years (p = 0.007), whereas positive and significant PCS-associated independent variables were years of education (p = 0.022), physical activity (p = 0.026). BMI was negatively associated with all the physical subscales of SF-36 (p < 0.05).ConclusionsResearch funding should be invested in the study of the benefits accruing from reducing obesity in the elderly.

show abstract

Protective effect of leg fat against cardiovascular risk factors in obese premenopausal women

Cited by 25 publications

References 44 publications

Depot‐ and ethnic‐specific differences in the relationship between adipose tissue inflammation and insulin sensitivity

Depot‐ and ethnic‐specific differences in the relationship between adipose tissue inflammation and insulin sensitivity

Cardiometabolic risk: leg fat is protective during childhood

Correlates of perceived health related quality of life in obese, overweight and normal weight older adults: an observational study

Contact Info

Product

Resources

About