Protective Effect of Lactobacillus sporogenes against Arsenic-Induced Hematological Alterations in Male Albino Wistar Rats

Bora, Swathi; Lakshman, M; Madhuri, D.; Kalakumar, B.; Udayakumar, M.

doi:10.1007/s12011-021-03055-9

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…(2022) also informed same results about the LYM, NEU, and MON ratios in male rats exposed to Cd. Bora et al (2022) suggested that LS administration improved the LYM, NEU, and MON ratios in As-induced Wistar male rats. It may be due to application route, dose, microorganism types or chemicals.…”

Section: 2anae-positive Lymphocyte Ratiosmentioning

confidence: 97%

“…As above mentioned, oral L. plantarum administration did not effect the MCV, MCH, and MCHC values of experimental groups in the present study. Bora et al (2022) suggested that supplemention of LS to diet improved the MCV, MCH, and MCHC values in rats exposed to As. Ghazanfarpour et al (2019) also reported that oral LF administration ameliorated the MCV and MCH values in male rats exposed to Pb.…”

Section: 2anae-positive Lymphocyte Ratiosmentioning

confidence: 99%

“…On the other hand, Sayed et al (2020) reported that dietary administration of L. acidophilus (0.009 x10 6 CFU/g of rat b.w for 30 days, p.o) improved the HGB and RBC values in Carbon Tetrachloride (Ct) exposed rats. Bora et al (2022) suggested that supplemention of Lactobacillus sporogenes to diet improved the RBC and HGB values in arsenic (As) exposed male Wistar rats. Similarly, Ghazanfarpour et al (2019) informed that oral Lactobacillus fermentum (1.5 ×108 cfu/mL for 8 weeks) administration led to recovery of Pb-induced changes in RBC, HGB, and HCT values in rats.…”

Section: 2anae-positive Lymphocyte Ratiosmentioning

confidence: 99%

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Kadmiyuma (CD) maruz kalan dişi sıçanlarda Lactobacillus plantarum (LP) uygulamasının bazı kan parametreleri ve ANAE-pozitif lenfosit oranları üzerine kısmi koruyucu etkileri

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Tavşanlı

Aydın

et al. 2023

Izmir Democracy University Health Sciences Journal

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We aimed to research the influences of oral L.plantarum administration on some blood parameters and alpha-naphthyl acetate esterase (ANAE)-positive lymphocyte ratios in female rats exposed chronically to Cd. In order to perform this investigation, rats were separated into four equal groups as control (C, n = 8), cadmium (Cd, n = 8), L.plantarum (n = 8), and Cd+ L.plantarum (n = 8). Cd (2.04 mg / mL) was orally applicated to Cd and Cd+ L.plantarum groups for 28 days. In addition, active-live L.plantarum (approximately 108 - 109 cfu / mL) was applicated orally to L.plantarum and Cd+ L.plantarum groups at the same time. C group animals received only fresh water and standard rat food during the study. After the applications, animals were decapitated and blood samples were collected for evaluating of some blood parameters (WBC and its different sub-types, RBC, HCT, MCV, MCH, MCHC, and PLT) and also ANAE-positive lymphocyte ratios. WBC counts were determined the highest in the Cd group compared to other experimental groups (p < 0.05). On the other hand, LP administration caused a significant amelioration in WBC counts of Cd+ L.plantarum group animals when compared to Cd group (p < 0.05). Although NEU counts were detected the highest in the Cd group, these counts decreased due to oral L.plantarum administration in Cd+ L.plantarum group (p < 0.05). Increased PLT values due to CD administration were fixed by using LP diet in the Cd+ L.plantarum group compared to the Cd group in the study (p < 0.05). In conclusion, L.plantarum partially affects female rats’ blood parameters from the harmful effects of Cd.

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Section: 2anae-positive Lymphocyte Ratiosmentioning

confidence: 97%

Section: 2anae-positive Lymphocyte Ratiosmentioning

confidence: 99%

Section: 2anae-positive Lymphocyte Ratiosmentioning

confidence: 99%

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Kadmiyuma (CD) maruz kalan dişi sıçanlarda Lactobacillus plantarum (LP) uygulamasının bazı kan parametreleri ve ANAE-pozitif lenfosit oranları üzerine kısmi koruyucu etkileri

Kısadere

Tavşanlı

Aydın

et al. 2023

Izmir Democracy University Health Sciences Journal

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“…Additionally, the activation of anti-inflammatory and antioxidant pathways of the host possibly also plays a role [10,11]. In the case of iAs, which is an anionic pollutant, protective effects of probiotics on animal models have also been observed [12][13][14]. Strains of lactobacilli have been reported to complex iAs and remove it from aqueous solutions with varying efficacies [15].…”

Section: Introductionmentioning

confidence: 99%

Phosphate Uptake and Its Relation to Arsenic Toxicity in Lactobacilli

Corrales,

Alcántara,

Clemente

et al. 2024

IJMS

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The use of probiotic lactobacilli has been proposed as a strategy to mitigate damage associated with exposure to toxic metals. Their protective effect against cationic metal ions, such as those of mercury or lead, is believed to stem from their chelating and accumulating potential. However, their retention of anionic toxic metalloids, such as inorganic arsenic, is generally low. Through the construction of mutants in phosphate transporter genes (pst) in Lactiplantibacillus plantarum and Lacticaseibacillus paracasei strains, coupled with arsenate [As(V)] uptake and toxicity assays, we determined that the incorporation of As(V), which structurally resembles phosphate, is likely facilitated by phosphate transporters. Surprisingly, inactivation in Lc. paracasei of PhoP, the transcriptional regulator of the two-component system PhoPR, a signal transducer involved in phosphate sensing, led to an increased resistance to arsenite [As(III)]. In comparison to the wild type, the phoP strain exhibited no differences in the ability to retain As(III), and there were no observed changes in the oxidation of As(III) to the less toxic As(V). These results reinforce the idea that specific transport, and not unspecific cell retention, plays a role in As(V) biosorption by lactobacilli, while they reveal an unexpected phenotype for the lack of the pleiotropic regulator PhoP.

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Phosphate Uptake and Its Relation with Arsenic Toxicity in Lactobacilli

Corrales,

Alcántara,

Clemente

et al. 2024

Preprint

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Use of probiotic lactobacilli has been proposed as a strategy to mitigate damage associated to exposure to toxic metals. Their protective effect against cationic metal ions, such as those of mercury or lead, is believed to stem from their chelating and accumulating potential. However, their retention of anionic toxic metalloids, such as inorganic arsenic, is generally lower. Through the construction of mutants in phosphate transporter genes (pst) in Lactiplantibacillus plantarum and Lacticaseibacillus paracasei strains, coupled with arsenate [As(V)] uptake and toxicity assays, we determined that the incorporation of As(V), which structurally resembles phosphate, is likely facilitated by phosphate transporters. Surprisingly, inactivation in Lc. paracasei of PhoP, the tran-scriptional regulator of the two-component system PhoPR, a signal transducer involved in phosphate sensing, led to an increased resistance to arsenite [As(III)]. In comparison to the wild type, the phoP strain exhibited no differences in the ability to retain As(III), and there were no observed changes in the oxidation of As(III) to the less toxic As(V). These results reinforce the idea that specific transport, and not unspecific cell retention plays a role in As(V) biosorption by lactobacilli, while they reveal an unexpected phenotype for the lack of the pleiotropic regulator PhoP.

show abstract

Protective Effect of Lactobacillus sporogenes against Arsenic-Induced Hematological Alterations in Male Albino Wistar Rats

Cited by 3 publications

References 9 publications

Kadmiyuma (CD) maruz kalan dişi sıçanlarda Lactobacillus plantarum (LP) uygulamasının bazı kan parametreleri ve ANAE-pozitif lenfosit oranları üzerine kısmi koruyucu etkileri

Kadmiyuma (CD) maruz kalan dişi sıçanlarda Lactobacillus plantarum (LP) uygulamasının bazı kan parametreleri ve ANAE-pozitif lenfosit oranları üzerine kısmi koruyucu etkileri

Phosphate Uptake and Its Relation to Arsenic Toxicity in Lactobacilli

Phosphate Uptake and Its Relation with Arsenic Toxicity in Lactobacilli

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