Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice

Xia, Tian; Sun, Lingyan; Gou, Lingshan; Xin, Ling; Feng, Yan; Wang, Ling; Yin, Xiaoxing; Liu, Yi

doi:10.1016/j.brainres.2013.01.048

Cited by 44 publications

(27 citation statements)

References 61 publications

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“…It has been reported that L-theanine treatment was able to restore reduced GSH, GSH-Px and GR activity in aluminium treated rats [30]. Decrease of GSH in mouse brain induced by chronic restraint stress was also prevented by L-theanine, leading to the prevention of the decline in learning and memory [31]. This preservation of endogenous antioxidants may explain why the L-theanine treatment was able to reduce ROS-induced by cadmium.…”

Section: Discussionmentioning

confidence: 87%

Protective Effect of l-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway

et al. 2015

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L-Theanine is an amino acid derivative from green tea. The present work was aimed at the effect of L-theanine on neuron-like rat pheochromocytoma (PC12) cells stimulated with cadmium chloride. Treatment with L-theanine before cadmium exposure increased cell viability; the experiments of Annexin V/PI staining indicated that L-theanine inhibited cadmium-induced cell apoptosis. Meanwhile, L-theanine decreased ROS production and protected from cadmium-induced disruption of mitochondrial transmembrane potential. Compared with cadmium-treated cells, L-theanine could also decrease the ratio of Bax/Bcl-2, as well as the level of cleaved caspase-9, caspase-3 and poly(ADP-ribose) polymerase. Furthermore, L-theanine depresses cadmium-induced up regulation of phosphorylations of PI3K/Akt, MAPK ERK1/2, and JNK signaling. These data suggest that L-theanine pretreatment reduces severity of cadmium toxicity probably via antioxidant action. Therefore, it may be concluded that L-theanine could be exploited for prevention of cadmium-induced diseases.

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Section: Discussionmentioning

confidence: 87%

Protective Effect of l-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway

et al. 2015

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“…In our study, the serum corticosterone level was markedly increased after noise exposure, while treatment with orientin markedly decreased the serum corticosterone level. Furthermore, catecholamines, such as NE and DA, are important monoamines widely distributed in the brain and their functional role during stressful conditions is well-established [11]. It has also been considered that stress-induced cognitive dysfunction is associated with the depletion of monoamines by sustained stress [40].…”

Section: Discussionmentioning

confidence: 99%

“…The apparatus consisted of a wooden box Step-through test: Immediately after the open field test, animals were tested for emotional cognitive impairment by the step-through avoidance test [11], which is considered to be a simple and rapid memory test. The test was conducted on 2 consecutive days at the same time of the day.…”

Section: Open-field Testmentioning

confidence: 99%

“…The increased level of serum catecholamines such as norepinephrine (NE) and dopamine (DA), is considered to be an immediate response in combating the stress induced by the activation of the SAM system [11]. Moreover, increasing evidence shows that the activation of the oxidative stress process by chronic stress may cause lipid peroxidation, reduced antioxidant enzyme activity, and increased monoamine catabolism, which are all related to cognitive decline [12].…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of the orientin on noise-induced cognitive impairments in mice

Wang

Feng

et al. 2016

Behavioural Brain Research

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There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noiseinduced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapseassociated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline. Disciplines Medicine and Health Sciences Publication DetailsWang, S., Yu, Y., Feng, Y., Zou, F., Zhang, X., Huang, J., Zhang, Y., Zheng, X., Huang, X., Zhu, Y. & Liu, Y. (2016). Protective effect of the orientin on noise-induced cognitive impairments in mice. Behavioural Brain Research, 296 290-300.

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“…L-Theanine has a structure similar to glutamate, which is a neurotransmitter related to memory, and binds to the gamma-Aminobutyric acid (GABA) receptors in neurons. L-Theanine is reported to reduce mental stress and to promote health, while improving cognition and protecting neurons [43][44][45][46][47]. Moreover, L-Theanine is reported to facilitate neurogenesis in the hippocampus of rats, leading to enhanced memory [48].…”

Section: Introductionmentioning

confidence: 99%

Treating multiple antiaging pathways improves health markers in open label clinical study

Villeponteau¹,

Still²

2017

transl med commun

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Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice

Cited by 44 publications

References 61 publications

Protective Effect of l-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway

Protective Effect of l-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway

Protective effect of the orientin on noise-induced cognitive impairments in mice

Treating multiple antiaging pathways improves health markers in open label clinical study

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