Protective effect of Kombucha tea on brain damage induced by transient cerebral ischemia and reperfusion in rat

Kabiri, Najmeh; Setorki, Mahbubeh

doi:10.3329/bjp.v11i3.27014

Cited by 11 publications

(3 citation statements)

References 13 publications

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“…Our studies showed new evidence that the chronic pre-treatment of KT alleviated brain edema formation following brain ischemia and reperfusion. These results agree with other studies showing anti-edematous properties of KT in focal brain ischemia and colitis models (Kabiri and Setorki 2016;Pakravan et al 2019). Studies have shown that in pathological situations such as ischemia, the balance between the production and removal of oxidants is impaired (Birben et al 2012).…”

Section: Discussionsupporting

confidence: 93%

Chronic Pre-Treatment of Kombucha Tea Protects Brain Injury induced by Ischemia/Reperfusion in Global Brain Ischemia

Mesgari‐Abbasi

Vaezi

Hossienzadeh

2022

Preprint

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Cerebral ischemia is an important factor in developing neurological damage without appropriate medical treatment. Kombucha tea(KT) is a fermented beverage that produces many compounds with antioxidant power with potential health effects. This study was performed to evaluate the effect of pre-treatment of kombucha tea on brain edema, neurobehavioral, and oxidative stress in the global brain ischemia model. Adult male Wistar rats were divided into four groups include; the sham, the ischemic, and the KT-treated-ischemic groups. KT was administrated two weeks before inducing transient global cerebral ischemia at two different dosages (one and two ml/kg/day, gavage). The global brain ischemia was induced by blocking the common carotid arteries for one hour, followed by 24 hours of reperfusion. At the end of reperfusion, neurobehavioral studies were done. Brain edema was determined by dry-wet methods. Malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) levels were measured in the serum and the brain tissue. Our results showed that pre-treatment of KT significantly reduced brain edema and MDA levels in the blood and the brain. It significantly increased the total TAC and GPx levels in the blood and the brain in ischemic rats treated with KT. The CAT activity significantly increased in the blood, but it didn’t significantly change the brain. KT of pre-treatment significantly ameliorated neurobehavioral defects in the ischemic rats. Our data demonstrated that pre-treatment of KT maybe protect the brain against ischemic-reperfusion injury through a decrease in the production of lipid peroxidation and an increase in the capacity of antioxidants defense.

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Section: Discussionsupporting

confidence: 93%

Chronic Pre-Treatment of Kombucha Tea Protects Brain Injury induced by Ischemia/Reperfusion in Global Brain Ischemia

Mesgari‐Abbasi

Vaezi

Hossienzadeh

2022

Preprint

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“…The anti-inflammatory effect of kombucha should be further studied in patients with MDD, especially regarding endotoxemia and its subsequent immune response. Moreover, in a rat model, kombucha seemed to increase the integrity of the blood–brain barrier (BBB) and decrease the brain and serum levels of the malondialdehyde (MDA), a marker of oxidative stress [ 179 ]. Interestingly, both an enhanced BBB permeability and changes in MDA levels have been observed in patients with MDD [ 180 , 181 ].…”

Section: Translational Opportunities: Clinical Management Of Mdd Thro...mentioning

confidence: 99%

Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder

et al. 2022

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Major Depressive Disorder (MDD) is a growing disabling condition affecting around 280 million people worldwide. This complex entity is the result of the interplay between biological, psychological, and sociocultural factors, and compelling evidence suggests that MDD can be considered a disease that occurs as a consequence of an evolutionary mismatch and unhealthy lifestyle habits. In this context, diet is one of the core pillars of health, influencing multiple biological processes in the brain and the entire body. It seems that there is a bidirectional relationship between MDD and malnutrition, and depressed individuals often lack certain critical nutrients along with an aberrant dietary pattern. Thus, dietary interventions are one of the most promising tools to explore in the field of MDD, as there are a specific group of nutrients (i.e., omega 3, vitamins, polyphenols, and caffeine), foods (fish, nuts, seeds fruits, vegetables, coffee/tea, and fermented products) or dietary supplements (such as S-adenosylmethionine, acetyl carnitine, creatine, amino acids, etc.), which are being currently studied. Likewise, the entire nutritional context and the dietary pattern seem to be another potential area of study, and some strategies such as the Mediterranean diet have demonstrated some relevant benefits in patients with MDD; although, further efforts are still needed. In the present work, we will explore the state-of-the-art diet in the prevention and clinical support of MDD, focusing on the biological properties of its main nutrients, foods, and dietary patterns and their possible implications for these patients.

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“…Under deep anesthesia, a midline incision was given on the anterior region of the neck to expose carotid sheath and then common carotid arteries were identified and isolated carefully from the vagosym pathetic nerve. Acute ischemic stroke was induced by temporary occlusion of the common carotid arteries (Kabiri and Setorki, 2016). Blood flow was restored after 60 min of occlusion.…”

Section: Induction Of Ischemiamentioning

confidence: 99%

Neuroprotective effect of <i>Ziziphus spina-christi</i> on brain injury induced by transient global cerebral ischemia and reperfusion in rat

Setorki

Hooshmandi

2017

Bangladesh J Pharmacol

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Neuroprotective effect of Neuroprotective effect of Neuroprotective effect of Ziziphus Ziziphus Ziziphus spina spina spina---christi christi christi on brain injury inon brain injury inon brain injury induced by transient global cerebral duced by transient global cerebral duced by transient global cerebral ischemia and reperfusion in rat ischemia and reperfusion in rat ischemia and reperfusion in rat BJP IntroductionCerebral ischemia occurs when the blood supply to the brain is halted or reduced (Bhuiyan and Kim, 2010). Several factors such as thrombosis, embolism, and systemic hypoperfusion can lead to ischemia (Lakhan et al., 2009). Ischemia reduces the delivery of oxygen and nutrients to the cell which eventually leads to organ dys -function. A reduction of oxygen supply reduces cellular ATP. Required ATP is produced through anaerobic respiration. This leads to an accumulation of lactate, acidosis and finally cell death (Wells et al., 2010).The hippocampus, which plays important roles in learning, memory and emotion, is highly vulnerable to ischemic insults. Hypoxia in this region can lead to inhibition of synaptic potential which is a key mechanism to reduce energy consumption (Meilandt et al., 2004). I/R-induced generation of reactive oxygen species can cause oxidative damage to biomolecules such as lipids, proteins and DNA (Chan, 2001). Increased production of ROS during cerebral ischemia has been considered as a major factor in delayed neuro-nal cell death, especially in hippocampal CA1 pyrami-dal neurons (Hara and Mori, 2000). Anti-oxidant agents may be effective in the treatment of memory and learning deficits. Recently, natural anti-oxidants from plant materials have been reported to reduce neuronal damage caused by free radical (Pham-Huy et al., 2008).Sidr tree (Ziziphus spina-christi, Family Rhamnaceae) is an evergreen tree native to the South of Iran. It has pulpy edible fruits. Traditionally, its leaves are used to treat sores, pneumonia, dysentery, ulcer and as an antiseptics. The leaves contain phytosterols such as β-sitosterol, glycoside, flavonoids, saponins, tannins and lactone (Asgarpanah and Haghighat, 2012). Hydroalcoholic extract of Ziziphus spina-christi was found to be effective against scopolamine-induced anxiety in rats (Setorki, 2016). There is no previous study on the learning and memory-enhancing activities of Z. spina- AbstractThis study evaluated the protective effect of Ziziphus spina-christi on the cerebral oxidative stress and damage induced by ischemia. Male Wistar rats were divided randomly into six groups (seven in each group): Control group did not undergo surgery and received distilled water; shame group underwent surgery without ischemia; ischemic group underwent ischemia without any medication; extract-treated groups underwent ischemia and orally received 50, 100, 200 mg/kg/day doses Z. spina-christi extract. After behavioral tests, anti-oxidant capacity and malondialdehyde level of brain and serum were determined. Treatment of ischemic rats with extract significantly i...

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Protective effect of Kombucha tea on brain damage induced by transient cerebral ischemia and reperfusion in rat

Cited by 11 publications

References 13 publications

Chronic Pre-Treatment of Kombucha Tea Protects Brain Injury induced by Ischemia/Reperfusion in Global Brain Ischemia

Chronic Pre-Treatment of Kombucha Tea Protects Brain Injury induced by Ischemia/Reperfusion in Global Brain Ischemia

Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder

Neuroprotective effect of <i>Ziziphus spina-christi</i> on brain injury induced by transient global cerebral ischemia and reperfusion in rat

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