Protective effect of Jiechangning decoction in treating experimental ulcerative colitis in guinea pigs

Xiong, Wei; Qiu, Qi-yu; Qiu, Dekai

doi:10.1007/bf02835750

Cited by 4 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The guinea pigs exhibited diffuse inflammatory ulcers from the cecum to the rectum, along with edema, inflammatory cell infiltration, and crypt abscesses. This model is straightforward and reproducible, making it suitable for studying the mechanisms of UC (Xiong et al., 2005). It is relatively common to evaluate the therapeutic effects and mechanisms of eicosapentaenoic acid ethyl ester, Jiechangning, and other drugs on colitis by this model.…”

Section: Chemically Induced Ibd Modelsmentioning

confidence: 99%

An evaluation of animal models for using bioactive compounds in the treatment of inflammatory bowel disease

Tie,

Chen,

Tan

2024

Food Frontiers

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a prevalent chronic relapsing‐remitting disease that affects the digestive tract and reduces patients’ quality of life. Food bioactive compounds are a promising approach for nutritional intervention of IBD with minimal side effects. To evaluate their potential, researchers have developed various animal models that simulate human IBD, including chemically induced, spontaneous, genetically engineered, and adoptive transfer models. In this work, the main animal models, pathogenesis, symptoms, strengths, and limitations of IBD were discussed. Although these models could not perfectly replicate human IBD, they provided useful tools to study the disease's progression and therapeutic processes. In addition, taking these IBD animals as models, the specific experimental methods, intervention results, and mechanisms of food bioactive compounds to prevent or treat IBD were described in detail. The continuous improvement of animal models is crucial to gain a better understanding of IBD's etiology and pathogenesis and to evaluate the efficacy of food bioactive compounds for the effective control of IBD.

show abstract

Section: Chemically Induced Ibd Modelsmentioning

confidence: 99%