Protective Effect of Jamun (Syzygium cumini) Seed and Orange (Citrus sinensis) Peel Extracts Against Lead-Induced Alteration in Liver Biomarkers of Rats

Abstract

The ameliorative effects of jamun seed extract (JSE) and orange peel extract (OPE) on lead induced alteration in liver biochemical parameters were investigated. One hundred twenty Wistar rats were divided into six groups (A-F). Group A (control): No treatment was given, Group B: lead nitrate (50 mg/kg b wt.) was given, Groups C: rats were given 50 mg/kg b wt. lead nitrate and 200 mg/kg b wt. Jamun seed extract, Group D rats were given 50 mg/kg b wt. lead nitrate and 200 mg/kg b wt. orange peel extract, Groups E: 200 mg/kg b wt. orange peel extract, and Group F rats were given a dose of 200 mg/kg b wt. jamun seed extract. The treatments were conducted for 14 days. On 7 th and 14 th day, blood samples were collected from each group and liver biochemical parameters were analyzed. In lead nitrate-treated rats liver biomarkers levels (serum alkaline phosphatase, serum SGOT, serum SGPT, serum bilirubin and serum lactate dehydrogenase) were increased at 7 day and 14 day whereas serum albumin levels decreased on 7 day to 14 day as compared to control. JSE and OPE exerts hepatoprotective effects against lead induced alternation in liver biomarkers as the changes in serum alkaline phosphatase, serum SGOT, serum SGPT, serum albumin, serum bilirubin and serum lactate dehydrogenase were recovered to near control values.