Protective effect of Thymus munbyanus aqueous extract against 2,4-dichlorophenoxyacetic acid-induced nephrotoxicity in Wistar rats

Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats

“…The role of the kidney in the metabolism and excretion of waste products makes this organ susceptible to toxic injuries and cell damage, resulting in kidney failure (Ben Othmène et al, 2020). The increased level of plasma urea, creatinine, and uric acid is a potential indicator of kidney damage in association with a reduction in glomerular filtration following pesticides treatment (Ben Othmène et al, 2020; Trea et al, 2022). The obtained results are in agreement with the findings of Chaâbane et al (2017) after treatment with penconazole, where the histopathological findings of kidney sections are in agreement with the results of biochemical markers.…”

“…The large use of pesticides has raised concerns about the risks of harmful residues in crops, affecting human health and environmental safety (Mesnage and Séralini., 2018). The general population is commonly exposed to pesticides via direct contact or ingestion of contaminated water and food, causing consequently serious health problems such as neurotoxicity (El-Hak and Mobarak., 2019), carcinogenicity (Greim el al., 2015), and nephro-hepatotoxicity (Tichati et al, 2020; Trea et al, 2022). Pesticides can induce oxidative stress by the generation of reactive oxygen species (ROS) (Devan et al, 2015), that are able to alter the vital cell components and intrinsic membrane properties like ion transport, DNA damage, etc., resulting in cell death (Halliwell and Gutteridge, 1990), and cell lipid peroxidation (Mahajan et al, 2018).…”