Protective effect of Astragalus corniculatus saponins against myeloid graffi tumour in hamsters

Abstract

A purified mixture containing mostly saponins (PMS) from Astragalus corniculatus Bieb. was used in an in vivo model to demonstrate its protective effect against myeloid Graffi tumour in hamsters. Survivability, tumour growth and tumour transplantability were followed. Comparative studies revealed that the intraperitoneal administration of PMS: (i) decreased the tumour transplantability; (ii) inhibited tumour growth in the early stages of tumour progression; (iii) increased the mean survival time; (iv) reduced the percentage mortality. These results suggest that appropriate use of PMS could outline a promising strategy for the treatment of myeloid Graffi tumour.

Exploitation of the Bulgarian Flora's Biodiversity as a Source of Immunomodulatory and/or Antineoplastic Agents: Current Challenges and Perspectives

“…The PMS treatment also was consistent with an increase in the mean survival time and reduction of the percentage mortality. These results suggest that appropriate use of PMS could outline a promising strategy for the treatment of myeloid Graffi tumour (22).…”

Protective Effects of Extract fromAstragalus Glycyphylloideson Carbon Tetrachloride-Induced Toxicity in Isolated Rat Hepatocytes

“…the authors suggested that the increased glutathione concentration was a result of activation of the turnover of glutathione and enzymes, stimulating particularly glutathione-S-transferases, permitting the captation of the reactive metabolites of the studied drugs (7).…”

Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2

“…The molecular basis of the anticancer activity of Radix Astragali extract has not been fully explored. Triterpenoid astragalosides and polysaccharides were suggested to be active against cancers (32,33). Recent studies showed that herbal polysaccharides modulate human immune system in a non-specific manner (34,35).…”