Protective effect of<i> Acorus calamus</i> against acrylamide induced neurotoxicity

Shukla, Pradeep Kumar; Khanna, Vinay K.; Ali, M. M.; Maurya, Rakesh; Handa, S. S.; Srimal, R. C.

doi:10.1002/ptr.854

Cited by 100 publications

(41 citation statements)

References 21 publications

(20 reference statements)

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“…Therefore, oxidant/antioxidant balance is spoiled, oxidative stress occurs and thereby, oxidative damage occurs in cells (1,14,(50)(51)(52). One study found that the level of thiobarbituric acid reactive products had increased signifi cantly in the liver samples taken from the rats administrated with acrylamide in acute dose.…”

Section: Discussionmentioning

confidence: 99%

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The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

Altınöz¹,

Türköz²,

Vardı³

2015

BLL

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Abstract:The aim of this study was to investigate the protective effects of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues in rats. The rats were divided into four groups. Acrylamide administration increased MDA levels in all tissues significantly (p < 0.05). But acrylamide+NAC administration decreased MDA levels signifi cantly as compared to the acrylamide group, and lowered it to a level close to the control group values (p < 0.05). GSH levels in liver and small intestine tissues reduced signifi cantly in the acrylamide group (p < 0.05). But acrylamide+NAC administration increased GSH levels signifi cantly in all tissues. Whereas GST activity decreased signifi cantly in the acrylamide group in liver and small intestine tissues as compared to the other groups (p < 0.05), the GST activity increased signifi cantly in the acrylamide+NAC group in all tissues as compared to the acrylamide group (p < 0.05). Liver histopathology showed that the liver epithelial cells were damaged signifi cantly in the acrylamide group. Small intestine histopathology showed that the intestinal villous epithelial cells were damaged signifi cantly in the acrylamide group. Our results indicate that a high level of acrylamide causes oxidative damage in liver and small and large intestine tissues, while N-acetylcysteine administration in a pharmacological dose shows to have an antioxidant effect in preventing this damage (Tab. 2, Fig. 2, Ref. 66). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

“…These results show that acrylamide causes a signifi cant decrease in antioxidant parameters. Acrylamide especially decreases the GSH and GST activity levels of cells, spoils the oxidant/antioxidant balance against the oxidants and thus leads to oxidative damage in cells (1,14,(50)(51)(52)(55)(56)(57)(58).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

Altınöz¹,

Türköz²,

Vardı³

2015

BLL

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“…Moreover, ACR exposure resulted in the central-peripheral neuropathy in humans (LoPachin, 2004) and in laboratory animals, including rats and monkeys (Seale et al, 2012). Shukla et al (2002) found hind limb paralysis in 58% of the rats treated with ACR for 10 d, which attributed to ACR neurotoxicity. El-Yamany and Bayomy (2007) concluded that the abnormal body posture, muscle weakness, and legs play accompanying ACR-intoxication in rats may be related to the degeneration of the brain monoaminergic system.…”

Section: Discussionmentioning

confidence: 99%

The effect of lipoic acid on acrylamide-induced neuropathy in rats with reference to biochemical, hematological, and behavioral alterations

Lebda¹,

Gad

Rashed

2015

Pharmaceutical Biology

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Context: Acrylamide (ACR) is a well-known neurotoxicant and carcinogenic agent which poses a greater risk for human and animal health. Objective: The present study evaluates the beneficial effects of a-lipoic acid (LA) on ACR-induced neuropathy. Materials and methods: A total of 40 male rats were divided into four groups: a placebo group; LA-treated group, administered orally 1% (w/w) LA mixed with diet; ACR-treated group, given 0.05% (w/v) ACR dissolved in drinking water; and LA + ACR-treated group, given LA 1% 7 d before and along with ACR 0.05% for 21 d. After 28 d, blood samples were collected, the rats were decapitated, and the tissues were excised for the measurement of brain biomarkers, antioxidant status, and hematological analysis. Also, the gait score of rats was evaluated. Results: ACR-exposed rats exhibited abnormal gait deficits with significant (p50.05) decline in acetylcholine esterase (AChE) and creatine kinase in serum and brain tissues, respectively. However, the lactate dehydrogenase activity was increased in serum by 123%, although it decreased in brain tissues by À74%. ACR significantly (p50.05) increased the malondialdehyde level by 273% with subsequent depletion of glutathione S-transferase (GST), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and reduced the glutathione (GSH) level in brain tissue. Interestingly, LA significantly (p50.05) improved brain enzymatic biomarkers, attenuated lipid peroxidation (LPO), and increased antioxidant activities compared with the ACR-treated group. Discussion and conclusion: These results suggested that LA may have a role in the management of ACR-induced oxidative stress in brain tissues through its antioxidant activity, attenuation of LPO, and improvement of brain biomarkers.

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“…The levels of GSH content and GST activity increased in the corpus striatum, where as the dopamine receptors decreased compared with the AC-treated rats. The results proved that the neurobehavioral changes produced by acrylamide was prevented with the treatment by ACrhizomes (Shukla et al, 2002). The neuroprotective potential of ethanol:water (1:1) extract of rhizomes of AC was reported in middle cerebral artery occlusion (MCAO)-induced ischemia in rats.…”

Section: Behavorial Changesmentioning

confidence: 74%

Acorus calamus.: Scientific Validation of Ayurvedic Tradition from Natural Resources

Mukherjee

Venkatesan

Mal

et al. 2007

Pharmaceutical Biology

109

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Acorus calamus Linn. (Araceae), commonly known as ''sweet flag'' or ''calamus'', is a semiaquatic, perennial, aromatic herb with creeping rhizomes. The plant is found in the northern temperate and subtropical regions of Asia, North America, and Europe. The plant exhibits polyploidy. Many ethnomedicinal and ethnobotanical uses have been ascribed to the rhizomes of the plant. A. calamus Linn. (AC) has been used as traditional Chinese and Indian prescriptions for its beneficial effects on memory disorder, learning performance, lipid peroxide content, and anti-aging and anticholinergic activity. Moreover, pharmacological studies have revealed that Acorus rhizome and its constituents, particularly a-and b-asarone, possess a wide range of pharmacological activities such as sedative, CNS depressant, behavior modifying, anticonvulsant, acetylcholinesterase inhibitory, memory enhancing, anti-inflammatory, antioxidant, antispasmodic, cardiovascular, hypolipidemic, immunosuppressive, cytoprotective, antidiarrheal, antimicrobial, anthelmintic, insecticidal, adulticidal, diuretic, antioxidant, genotoxic, and mutagenic activities. This review is an effort to explore the different phytoconstituents and pharmacological activities of Acorus calamus.

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Protective effect of Acorus calamus against acrylamide induced neurotoxicity

Cited by 100 publications

References 21 publications

The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

The effect of lipoic acid on acrylamide-induced neuropathy in rats with reference to biochemical, hematological, and behavioral alterations

Acorus calamus.: Scientific Validation of Ayurvedic Tradition from Natural Resources

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