Protective effect of hydroxysafflor yellow A on MSCs against senescence induced by  -galactose

Song, Xiu–Peng; Wang, Jinying; Du, Xinqian; Qian, Qibing

doi:10.1016/j.chmed.2022.06.011

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Based on its neuroprotective effect on cerebral ischemia and anti-inflammatory, anti-oxidative effects, hydroxysafflor Yellow A can improve cognitive dysfunction after cerebral ischemia. 60,61 Our current results suggested that AGEs-RAGE mediates the production of Aβ and P-Tau, and this effect was significantly reduced by treatment with THSWD or positive drugs. Moreover, the results suggested that THSWD has a protective effect on STZ-induced hippocampal neuronal damage and can improve learning and memory abilities, which can be achieved by inhibiting the AEGs-RAGE pathway.…”

Section: Discussionmentioning

confidence: 53%

“…Hydroxysafflor Yellow A is the major active chemical component of Carthami Flos . Based on its neuroprotective effect on cerebral ischemia and anti‐inflammatory, anti‐oxidative effects, hydroxysafflor Yellow A can improve cognitive dysfunction after cerebral ischemia 60,61 . Our current results suggested that AGEs‐RAGE mediates the production of Aβ and P‐Tau, and this effect was significantly reduced by treatment with THSWD or positive drugs.…”

Section: Discussionmentioning

confidence: 54%

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The Tao Hong Si Wu Decoction ameliorates diabetes‐associated cognitive dysfunction by inhibiting the formation of amyloid plaques

Cai,

Chen,

Zhang

et al. 2024

Int J Geriat Psychiatry

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ObjectivesThe herbs in Tao Hong Si Wu Decoction (THSWD) are beneficial in the treatment of cognitive impairment. However, the underlying mechanisms of THSWD in treating diabetes‐associated cognitive dysfunction (DACD) are not entirely explored. This study is aimed to investigate the therapeutic effects of THSWD in DACD model rats and the underlying mechanism.MethodsUltra‐high‐phase liquid chromatography was employed to identify the main compounds contained in the THSWD extract. DACD rat model was induced by feeding with a high‐sugar and high‐fat diet and injecting streptozotocin (35 mg/kg). DACD rats were gavaged with THSWD for 1 week. The learning and memory abilities of the rats were measured by using the Morris water maze. Western blotting was used to detect the changes in DACD rat targets. Statistical methods were used to evaluate the correlation between proteins.ResultsThe results show that THSWD effectively reduced the escape latency, hippocampal neuron damage, glycosylated hemoglobin, type A1C, and blood lipid levels in DACD rats. Furthermore, DACD rats showed significantly increased amyloid precursor protein, β‐secretase, Aβ1−40, Aβ1−42, Tau phosphorylation, and advanced glycation end products (AGEs) expression. However, THSWD treatment can reverse this phenomenon.ConclusionsTHSWD can improve the learning and memory abilities of DACD rats by inhibiting the expression of AEGs‐AGE receptors pathway, which provides an experimental basis for the clinical application of THSWD. In addition, the experiment combines pharmacological and statistical methods, which offers a new perspective for the study of Chinese herbal medicine.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 54%

The Tao Hong Si Wu Decoction ameliorates diabetes‐associated cognitive dysfunction by inhibiting the formation of amyloid plaques

Cai,

Chen,

Zhang

et al. 2024

Int J Geriat Psychiatry

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Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis

Liu,

Chen,

Wang

et al. 2024

British J Pharmacology

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Background and PurposeColorectal cancer (CRC) ranks second in mortality worldwide and requires effective and affordable remedies. Cyclovirobuxine D (CVB‐D) is the main effective component of Huangyangning tablet, an approved traditional patent medicine, which is mainly used for cardiovascular treatment. As a multibioactive natural compound, CVB‐D possesses underlying anticancer activities.Experimental ApproachCell viability and clone‐forming ability were determined in human CRC lines. Western blot, immunofluorescence assay, transmission electron microscopy and senescence‐associated β‐galactosidase (SA‐β‐Gal) staining were utilized to investigate cell autophagy and senescence. The molecular mechanisms were explored by virtual prediction and experimental validation. Patient‐derived xenograft (PDX), dextran sulfate sodium salt (DSS), and azomethane (AOM)/DSS mouse models were employed for in vivo studies.Key ResultsCVB‐D inhibited the growth and development of advanced CRC cells / mice by inducing autophagic and senescent activities through the chaperonin containing TCP1 subunit 3 (CCT3)/yes‐associated protein (YAP) axis. CVB‐D acted as a promising inhibitor of CCT3 by interacting with its ATP site. In PDX tumours, CVB‐D showed potential therapeutic effects by targeting CCT3. Treatment with CVB‐D alleviated the mouse model of colitis induced by DSS and attenuated AOM/DSS‐induced formation of adenomatous polyps by its action on CCT3.Conclusions and ImplicationsOur study has provided a scientific basis for the suggestion that CVB‐D may be recognized as a prospective drug candidate for the therapy of CRC in patients.

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Protective effect of hydroxysafflor yellow A on MSCs against senescence induced by -galactose

Cited by 2 publications

References 29 publications

The Tao Hong Si Wu Decoction ameliorates diabetes‐associated cognitive dysfunction by inhibiting the formation of amyloid plaques

The Tao Hong Si Wu Decoction ameliorates diabetes‐associated cognitive dysfunction by inhibiting the formation of amyloid plaques

Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis

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