Protective effect of hydrogen sulfide on gentamicin-induced renal injury

Ötünçtemur, Alper; Özbek, Emin; Dursun, Murat; Şahin, Süleyman; Beşiroğlu, Hüseyin; Özsoy, Özgür Doğa; Çekmen, Mustafa; Somay, Adnan; Özbay, Nurver

doi:10.3109/0886022x.2014.900599

Cited by 35 publications

(24 citation statements)

References 37 publications

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“…As previously mentioned, there are compounds in the extract with high antioxidant potential such as polyphenols and flavonoids that can somewhat explain the effects of extracts on reducing tissue damage and improving performance …”

Section: Discussionmentioning

confidence: 99%

Pimpinella anisum L. ethanolic extract ameliorates the gentamicin‐ induced nephrotoxicity in rats

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Pimpinella anisum L. ethanolic extract ameliorates the gentamicin‐ induced nephrotoxicity in rats

et al. 2017

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“…In rats, NaHS administered via i.p. injections for 14 days attenuated oxidative stress (increased GSH and decreased malondialdehyde (MDA) and NO levels), leukocyte infiltration and structural damage in the kidneys [97]. On the other hand, in a similar experiment conducted by Van Dam et al NaHS treatment was not found to be protective [96].…”

Section: H2s In the Onset And Progression Of Renal Diseasementioning

confidence: 87%

Hydrogen sulfide in renal physiology, disease and transplantation – The smell of renal protection

et al. 2015

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“…The dehydrated NaHS powder was freshly dissolved with physiological saline for use. The doses and administration way of NaHS were adopted based on previous reports (Otunctemur et al, ; Wu et al, ).…”

Section: Methodsmentioning

confidence: 99%

Hydrogen sulfide alleviates uranium‐induced acute hepatotoxicity in rats: Role of antioxidant and antiapoptotic signaling

Yuan

Zheng

Zhao

et al. 2016

Environmental Toxicology

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As an endogenous gaseous mediator, H S exerts antioxidative, antiapoptotic, and cytoprotective effects in livers. This study was designed to investigate the protective role of H S against uranium-induced hepatotoxicity in adult SD male rats after in vivo effect of uranium on endogenous H S production was determined in livers. The levels of endogenous H S and H S-producing enzymes (CBS and CSE) were measured in liver homogenates from uranium -intoxicated rats. In rats injected intraperitoneally (i.p.) with uranyl acetate or NaHS (an H S donor) alone or in combination, we examined biochemical parameters to assess liver function, revealed hepatic histopathological alteration, investigated oxidative stress markers, and explored apoptotic signaling in liver homogenates. The results suggest that uranium-intoxication in rats decreased CBS and CSE protein expression, H S synthesis capacity, and endogenous H S generation. NaHS administration in uranium-intoxicated rats produced amelioration in liver biochemical indices and histopathological effects, decreased MDA content, and increased GSH level and antioxidative enzymes activities like SOD, CAT, GPx, and GST. NaHS administration in uranium-intoxicated rats attenuated uranium-activated phosphorylation state of JNK. NaHS treatment in uranium-intoxicated rats increased antiapoptotic Bcl-2 but decreased pro-apoptotic Bax, resulting in the rise of Bcl-2/Bax ratio. NaHS treatment in uranium-intoxicated rats reduced the apoptosis mediator caspase-3 and cytochrome c release and elevated ATP contents. Taken together, these data implicate that H S can afford protection to rat livers against uranium-induced adverse effects mediated by up-regulation of antioxidant and antiapoptotic signaling. The anti-apoptotic property of H S may be involved, at least in part, in inhibiting JNK signaling. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 581-593, 2017.

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Protective effect of hydrogen sulfide on gentamicin-induced renal injury

Abstract: We can say that H2S prevent kidney damage with antioxidant and anti-inflammatory effect.

Cited by 35 publications

References 37 publications

Pimpinella anisum L. ethanolic extract ameliorates the gentamicin‐ induced nephrotoxicity in rats

Pimpinella anisum L. ethanolic extract ameliorates the gentamicin‐ induced nephrotoxicity in rats

Hydrogen sulfide in renal physiology, disease and transplantation – The smell of renal protection

Hydrogen sulfide alleviates uranium‐induced acute hepatotoxicity in rats: Role of antioxidant and antiapoptotic signaling

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