Protective Effect of Hydrogen-rich Water against Gentamicin-induced Nephrotoxicity in Rats using Blood Oxygenation Level-dependent MR Imaging

Matsushita, Taro; Kusakabe, Yoshinori; Kitamura, Akihiro; Okada, S.; Murase, Kenya

doi:10.2463/mrms.10.169

Cited by 15 publications

(13 citation statements)

References 27 publications

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“…It has also been shown that magnetized water administration can reduce blood glucose level and improve the antioxidant status and lipid profiles in the heart, spleen, and lung of streptozotocin-induced diabetic rats [ 19 ]. Furthermore, magnetized water has been used to rescue cisplatin-induced nephrotoxicity [ 21 , 22 ], ferric-induced nephrotoxicity [ 23 ], and gentamicin-induced nephrotoxicity [ 24 ]. Even more, drinking magnetic water may have a useful role in inhibiting blood parameter disorders of type 2 diabetes mellitus [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

Zayed

Saleh

Gomaa

et al. 2018

Oxidative Medicine and Cellular Longevity

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We aimed in our current study to explore the protective effect of Ginkgo biloba (GB) and magnetized water (MW) against nephrotoxicity associating induced type 2 diabetes mellitus in rat. Here, we induced diabetes by feeding our lab rats on a high fat-containing diet (4 weeks) and after that injecting them with streptozotocin (STZ). We randomly divided forty rats into four different groups: nontreated control (Ctrl), nontreated diabetic (Diabetic), Diabetic+GB (4-week treatment), and Diabetic+MW (4-week treatment). After the experiment was finished, serum and kidney tissue samples were gathered. Blood levels of glucose, triglycerides, cholesterol, creatinine, and urea were markedly elevated in the diabetic group than in the control group. In all animals treated with GB and MW, the levels of urea, creatinine, and glucose were significantly reduced (all P < 0.01). GB and MW attenuated glomerular and tubular injury as well as the histological score. Furthermore, they normalized the contents of glutathione reductase and SOD2. In summary, our data showed that GB and MW treatment protected type 2 diabetic rat kidneys from nephrotoxic damages by reducing the hyperlipidemia, uremia, oxidative stress, and renal dysfunction.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

Zayed

Saleh

Gomaa

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…The effects of hydrogen rich water on gentamicin induced nephrotoxicity was analyzed by Matsushita et al It was discovered that hydrogen rich water was able to improve renal dysfunction caused by nephrotoxicity by reducing oxidative stress as well as lowering serum creatinine (Cr) and blood urea nitrogen (BUN) when compared to control rats [26]. Positive results of hydrogen rich saline were also observed when used as a treatment after renal ischemia and reperfusion injury.…”

Section: Mechanismsmentioning

confidence: 99%

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

2013

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Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these ideal locations of the cell, previous studies have shown that hydrogen exerts antioxidant, anti-apoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell. Hydrogen is most commonly applied as a gas, water, saline, and can be applied in a variety of other mediums. There are also few side effects involving hydrogen, thus making hydrogen a perfect medical gas candidate for the convention of novel therapeutic strategies against cardiovascular, cerebrovascular, cancer, metabolic, and respiratory diseases and disorders. Although hydrogen appears to be faultless at times, there still are several deficiencies or snares that need to be investigated by future studies. This review article seeks to delve and comprehensively analyze the research and experiments that alludes to molecular hydrogen being a novel therapeutic treatment that medicine desperately needs.

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“…HRSS has also been implicated in attenuating I/R-induced renal injury ( Shingu et al, 2010 ; Wang et al, 2011 , 2014 ). Some studies have also shown that H 2 can protect the kidneys from drug injuries ( Matsushita et al, 2011 ; Katakura et al, 2012 ). It remains unknown, however, whether HRSS can facilitate renal function recovery after I/R injury in rats.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation

Zhang

Liu

et al. 2016

Front. Pharmacol.

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Purpose: Hydrogen is a proven novel antioxidant that selectively reduces hydroxyl radicals. In this study, we investigated the effects of hydrogen-rich saline solution on the prevention of renal injury induced by ischemia/reperfusion (I/R) and on renal function recovery.Methods: A rat model of renal I/R injury was induced by 45 min occlusion of the left renal pedicle, followed by 108 h reperfusion. The right kidney was surgically removed. Then, 0.9% NaCl solution (1 ml/kg) or hydrogen-rich saline solution (HRSS; 1 ml/kg) was injected into the abdominal cavity at 4 h intervals. We assessed the influence of HRSS or control saline solution on the recovery of renal function after I/R injury. Kidney tissues were taken at different time points (24, 36, 48, 72, and 108 h after reperfusion) and frozen (-80°C). Kidney cell apoptosis was evaluated using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive staining. Additionally, the apoptotic factors (Bcl-2, Bax, caspase-3, caspase-9, and caspase-8) and the pro-inflammatory cytokines (IL-6 and TNF-α) were measured in the kidney tissues. Finally, serum blood urea nitrogen (BUN) and creatinine (Cr) levels were measured.Results: Histological analyses revealed a marked reduction of interstitial congestion, edema and hemorrhage in renal tissue after HRSS treatment compared to saline treatment. After I/R injury, BUN, Cr, Bcl-2, caspase-3, caspase-9, caspase-8, IL-6, and TNF-α were all significantly increased, while Bax expression was decreased. HRSS remarkably reversed these changes. Moreover, BUN and Cr decreased more rapidly in the rats treated with HRSS compared to the rats treated with control saline solution.Conclusions: HRSS showed a protective effect in the prevention of renal injury and could promote renal function recovery after I/R injury in rats. HRSS might partially exert its role through an anti-apoptotic and anti-inflammatory action in kidney cells.

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Protective Effect of Hydrogen-rich Water against Gentamicin-induced Nephrotoxicity in Rats using Blood Oxygenation Level-dependent MR Imaging

Cited by 15 publications

References 27 publications

Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation

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