Protective effect of hydro alcoholic extract from prosopisfarcta leaves on lipid peroxidation of serum and liver tissue in diabetic rats

Abstract

Background & objectives: Diabetes is a common endocrine disorder that can lead to hyperglycemia and hyperlipidemia. Nowadays, herbal plants are utilized as inexpensive medicines with low adverse effects for treatment of diabetic disorders. In this study, the effect of hydro-alcoholic extract of prosopis fracta leaves was investigated on liver tissue and serum level of malondialdehyde in streptozotocininduced diabetic rats. Materials & Methods: Male rats (n = 45) were randomly divided into 3 groups(normal control, diabetic control and diabetic treated with Prosopis farcta extract). Type 1 diabetes was induced in male wistar rats by injection of 42 mg/kg of streptozotocin. 300 mg/kg of Prosopis farcta leaves extract was administered after induction of diabetes for 30 days. The group of normal control and diabetic control received normal saline. After tissue processing, histopathological changes of liver were examined under light microscopy. The serum and liver concentration of MDA were determined as thiobarbituric acid reactive substances. Finally, the obtained data were statistically analyzed using Student's t-test and Mann-Whitney rank sum test. Results: Induction of diabetes with streptozotocin caused a statistically significant increases of MDA in serum and liver tissues (p<0.05). Administration of Prosopis fracta leaves extract significantly decreased concentration of malondialdehyde content in liver tissue and serum of diabetic rats (p<0.05).Histopathological findings confirmed the effective role of this extract in treatment of diabetic disorders. Conclusion: Hydro-alcoholic extract of Prosopis fracta could reduce level of malondialdehyde content in liver and prevent lipid peroxidation of cellular membranes associated with diabetes.

Hydroalcoholic Extract from PROSOPIS Fracta Leaves Protects against Liver Injury Elicited by High-Fat Diet in Rats

“…These findings are in accord with earlier studies and may reflect the ethnobotanical indication of P farcta extract on the reduction of chest pain (20). A previous report found that P farcta leaves possessed hepatoprotective and anti-lipid peroxidation activities in diabetic rats (21). The most unpredictable finding of the present study was a significant reduction in serum triglycerides, total cholesterol and LDL-C without a noticeable HDL-increasing effect.…”

Antifungal and anti-termite activities, total phenolic content of Prosopis Farcta extracts; and attempts to develop weed biocontrol method against it

“…Hydro-alcoholic extract (plant parts unknown) reduced level of malondialdehyde in liver. 38 Root aqueous extract had significantly decreased rabbits liver injuries. 44 80% Ethanol/water extract had a protective effect against acetaminophen-induced hepatotoxicity in rats.…”

“…Clear activity was observed. [33][34][35][36][37][38][39]48 Diabetes was induced in cell lines with various agents and treated with plant infusion and n-hexane and acetone extracts. All plants products had glucose lowering effect.…”

“…31 80% EtOH/H2O leaves extract had clear antioxidant (lipids) effect on STZ-induced diabetes in rats. 38 70% Aq. EtOH fruits extract had explicit activity (FRAP) 39…”