Protective effect of HTK solution on postoperative pulmonary function in infants with CHD and PAH

Li, Jindong; Wu, Yanhong; Tian, Xudong; Wang, Jian-tang; Dong, Miao; Wang, Anbiao; Ma, Shaolin

doi:10.1042/bsr20170984

Cited by 4 publications

(4 citation statements)

References 16 publications

(13 reference statements)

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“…In the study recently conducted by Li et al [ 17 ] (2017), the effects of HTK on pulmonary arterial perfusion and lung protection during CPB were investigated. Their patients were divided into two groups, the HTK group and the control group.…”

Section: Discussionmentioning

confidence: 99%

Comparison between the Effects of Bretschneider’s HTK Solution and Cold Blood Cardioplegia on Systemic Endothelial Functions in Patients who Undergo Coronary Artery Bypass Surgery: a Prospective Randomized and Controlled Trial

Mercan¹,

Dereli²,

Topcu³

et al. 2020

Braz J Cardiovasc Surg

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Coronary fistulas are rare anomalies that can affect approximately 1% of the population, presenting few specific symptoms, and are often found occasionally in coronary angiography. Here we describe the case of a 61-year-old patient with complaints of precordialgia and dyspnea since adolescence, with late diagnosis of coronary fistulas with drainage to the pulmonary artery, and with unsuccessful percutaneous treatment. Therefore, she underwent open surgery for the correction of the already known fistulas, in addition to the hemangioma involving such vessels, which made the understanding and resolution of this case more complex.

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Section: Discussionmentioning

confidence: 99%

Comparison between the Effects of Bretschneider’s HTK Solution and Cold Blood Cardioplegia on Systemic Endothelial Functions in Patients who Undergo Coronary Artery Bypass Surgery: a Prospective Randomized and Controlled Trial

Mercan¹,

Dereli²,

Topcu³

et al. 2020

Braz J Cardiovasc Surg

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“…The heart was perfused with HTK solution 4 °C via the tip of heart at a constant perfusion pressure of 80 ± 2 mmHg using a peristaltic pump (Gilson Minipuls 4, Middleton, WI, USA). [K + ] concentration in HTK solution is 9 mmol/L, low potassium can avoid the injury of high concentration of potassium on myocardium and coronary artery endothelium and make cardiac arrest during diastolic phase [23] . Then the heart was perfused in 10% formalin, and harvest.…”

Section: Methodsmentioning

confidence: 99%

Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation

Jiang

Liu

et al. 2018

Redox Biology

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Dilated cardiomyopathy (DCM) is a severe disorder caused by medications or genetic mutations. D5 dopamine receptor (D5R) gene knockout (D5-/-) mice have cardiac hypertrophy and high blood pressure. To investigate the role and mechanism by which the D5R regulates cardiac function, we generated cardiac-specific human D5R F173L(hD5F173L-TG) and cardiac-specific human D5R wild-type (hD5WT-TG) transgenic mice, and H9c2 cells stably expressing hD5F173L and hD5WT. We found that cardiac-specific hD5F173L-TG mice, relative to hD5WT-TG mice, presented with DCM and increased cardiac expression of cardiac injury markers, NADPH oxidase activity, Nrf2 degradation, and activated ERK1/2/JNK pathway. H9c2-hD5F173L cells also had an increase in NADPH oxidase activity, Nrf2 degradation, and phospho-JNK (p-JNK) expression. A Nrf2 inhibitor also increased p-JNK expression in H9c2-hD5F173L cells but not in H9c2-hD5WT cells. We suggest that the D5R may play an important role in the preservation of normal heart function by inhibiting the production of reactive oxygen species, via inhibition of NADPH oxidase, Nrf2 degradation, and ERK1/2/JNK pathways.

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“…Increasing evidence indicates that lung tissue protection by pulmonary artery perfusion with blood [15,16,17,18,19,20,21] or a preservation solution [22,23,24,25] such as hypothermic histidine-tryptophan-ketoglutarate (HTK [24,25,26]) during CPB may attenuate postoperative hypoxemia by supplying metabolic substrates to the lung tissue exposed to re-perfusion [27]. Hypothermic HTK is used as a multi-organ preservation solution for organ transplantation, including the lungs [25,28,29,30], in addition to its use as a cardioplegia solution. Its buffer system is thought to withdraw extracellular sodium and calcium, together with buffering of the extracellular space by means of histidine and histidine-hydrochloride, thus prolonging the period during which organs tolerates interruption in blood supply [31].…”

Section: Introductionmentioning

confidence: 99%

Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients

et al. 2018

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Pulmonary dysfunction is among the most frequent complications to cardiac surgeries. Exposure of blood to the cardiopulmonary bypass (CPB) circuit with subsequent lung ischemia-reperfusion leads to the production of inflammatory mediators and increases in microvascular permeability. The study aimed to elucidate histological, cellular, and metabolite changes following two lung protective regimens during CPB with Histidine-Tryptophan-Ketoglutarate (HTK) enriched or warm oxygenated blood pulmonary perfusion compared to standard regimen with no pulmonary perfusion. A total of 90 patients undergoing CPB were randomized to receiving HTK, oxygenated blood or standard regimen. Of these, bronchoalveolar lavage fluid (BALF) and lung tissue biopsies were obtained before and after CPB from 47 and 25 patients, respectively. Histopathological scores, BALF cell counts and metabolite screening were assessed. Multivariate and univariate analyses were performed. Profound histological, cellular, and metabolic changes were identified in all patients after CPB. Histological and cellular changes were similar in the three groups; however, some metabolite profiles were different in the HTK patients. While all patients presented an increase in inflammatory cells, metabolic acidosis, protease activity and oxidative stress, HTK patients seemed to be protected against severe acidosis, excessive fatty acid oxidation, and inflammation during ischemia-reperfusion. Additional studies are needed to confirm these findings.

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Protective effect of HTK solution on postoperative pulmonary function in infants with CHD and PAH

Cited by 4 publications

References 16 publications

Comparison between the Effects of Bretschneider’s HTK Solution and Cold Blood Cardioplegia on Systemic Endothelial Functions in Patients who Undergo Coronary Artery Bypass Surgery: a Prospective Randomized and Controlled Trial

Comparison between the Effects of Bretschneider’s HTK Solution and Cold Blood Cardioplegia on Systemic Endothelial Functions in Patients who Undergo Coronary Artery Bypass Surgery: a Prospective Randomized and Controlled Trial

Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation

Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients

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