Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway

Abstract

Objective This study was to detect the protective effects of Houttuynia cordata extract on the damage induced by propofol in hippocampal neuron of rats. Methods Propofol-induced neuron injury model and H. cordata extract administration were conducted. Immunofluorescence and immunoblot were conducted for the effect of H. cordata extract on neuronal activity and inflammation were detected in this model. Results H. cordata extracts increased neuronal activity, and reduced propofol-induced neuronal inflammation levels. H. cordata extract also reduced propofol-induced neuronal apoptosis. Mechanically, we noticed H. cordata extract activated phosphoinositide 3-kinase/AKT pathway and suppressed Toll-like receptor 4/nuclear factor kappaB pathway, therefore protected propofol-induced injury of rat hippocampal neurons. Conclusion Our findings provide references for anesthetic use in infants and young children.

Inhibition of LPS-Induced Skin Inflammatory Response and Barrier Damage via MAPK/NF-κB Signaling Pathway by Houttuynia cordata Thunb Fermentation Broth

“…It has been demonstrated that the ethanol extract of Houttuynia cordata Thunb can successfully reduce the oxidative damage to the liver and atherosclerosis brought on by a high-fat diet in rats [8]. Fang demonstrated that Houttuynia cordata Thunb extract could decrease the initiation of neuronal inflammation and apoptosis induced by propofol by enhancing neuronal activity [9]. Houttuynia cordata Thunb has shown good bacteriostatic activity against bacteria such as Staphylococcus aureus and Casecoccus [10].…”