Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice

Antunes, Michelle S.; Goes, André Tiago Rossito; Boeira, Silvana Peterini; Prigol, Marina; Jessé, Cristiano Ricardo

doi:10.1016/j.nut.2014.03.024

Cited by 117 publications

(49 citation statements)

References 49 publications

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“…It has been extensively studied for its biological activities including antioxidant, anti-inflammatory, antihypercholesterolemic, and anticarcinogenic properties [17,[22][23][24][25]. The antioxidant activity of hesperidin has been used to protect against various types of insults such as cisplatin-induced acute renal injury [ 26], benzopyrene-induced lung carcinogenesis [27], 6hydroxydopamine-induced Parkinson's disease [28], and depressant in streptozotocin-induced diabetic rats [29]. In the present study, we found that hesperidin pretreatment significantly attenuated hepatic lipid peroxidation and GSH depletion in rats administered with INH plus RFP.…”

Section: Discussionmentioning

confidence: 99%

Hesperidin Alleviates Oxidative Stress and Upregulates the Multidrug Resistance Protein 2 in Isoniazid and Rifampicin‐Induced Liver Injury in Rats

Zhang

Zhu

Zhou

et al. 2016

J Biochem & Molecular Tox

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Isoniazid (INH) and rifampicin (RFP), two front-line drugs used in tuberculosis therapy, may lead to seriously hepatotoxicity. The current study was carried out to investigate the hepatoprotective effects of hesperidin against INH-and RFP-induced oxidative damage. The liver injury animal model of rats was induced by INH (75 mg/kg) and RFP (150 mg/kg) coadministration for 7 days, and hesperidin, at the dose of 50, 100, and 200 mg/kg, was orally administered to rats 2 h before INH and RFP administration. The biochemical and pathologic examinations were performed after rats were sacrificed. Moreover, the serum and liver glutathione (GSH), glutathione disulfide (GSSG), malondialdehyde (MDA), GSH peroxidase, and GSSG reductase were determined by test kits, and the expression of multidrug resistance proteins 2 (Mrp2) was determined by Western blotting and immunohistochemistry. The results showed that hesperidin significantly alleviated liver injury as indicated by the decreased levels of ALT, AST, bilirubin, total bile acid, and glutathione peroxidase and the increased levels of the GSH/GSSG ratio and the expression of Mrp2. Moreover, hesperidin could effectively reduce the pathological tissue damage. These results indicate that hesperidin can attenuate INH-and RFP-induced oxidative damage, and the underlying mechanism may have correlation with its effect on the upregulation of Mrp2.

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Section: Discussionmentioning

confidence: 99%

Hesperidin Alleviates Oxidative Stress and Upregulates the Multidrug Resistance Protein 2 in Isoniazid and Rifampicin‐Induced Liver Injury in Rats

Zhang

Zhu

Zhou

et al. 2016

J Biochem & Molecular Tox

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“…Siddique et al [120] demonstrated the neuroprotective effect of Ocimum sanctum leaf extract in the transgenic Drosophila model of PD. Antunes et al [121] suggested that hesperidin attenuated 6-hydroxydopamine induced oxidative stress in aged mice. Pérez-Barrón et al [122] explored the antioxidant and neuroprotective effect of Buddleja cordata methanolic extract in the 1-methyl-4-phenylpyridinium induced PD rat model.…”

Section: Natural Products and Parkinson's Diseasementioning

confidence: 99%

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

Manoharan

Guillemin

Abiramasundari

et al. 2016

Oxidative Medicine and Cellular Longevity

377

271

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Neurodegenerative diseases affect not only the life quality of aging populations, but also their life spans. All forms of neurodegenerative diseases have a massive impact on the elderly. The major threat of these brain diseases includes progressive loss of memory, Alzheimer's disease (AD), impairments in the movement, Parkinson's disease (PD), and the inability to walk, talk, and think, Huntington's disease (HD). Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status, has been known to play a vital role in the pathophysiology of neurodegenerative diseases including AD, PD, and HD. A large number of studies have utilized oxidative stress biomarkers to investigate the severity of these neurodegenerative diseases and medications are available, but these only treat the symptoms. In traditional medicine, a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases. Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models. This short review focuses the role of oxidative stress in the pathogenesis of AD, PD, and HD and the protective efficacy of natural products against these diseases.

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“…Most of the data are related to the potential of flavonoids to prevent cognitive deficits or rescue learning and memory impairments in pathological contexts, including animal models for Alzheimer’s (Gu et al, 2016), Parkinson’s (Antunes et al, 2014) and Huntington’s diseases (Sandhir and Mehrotra, 2013) and in Multiple Sclerosis (Makar et al, 2016). Nevertheless, it has been showed that these compounds may also improve the cognitive ability of healthy young and old animals (van Praag et al, 2007; Williams et al, 2008; Rendeiro et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1

Matias

Diniz

Buosi

et al. 2017

Front. Aging Neurosci.

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Synapse formation and function are critical events for the brain function and cognition. Astrocytes are active participants in the control of synapses during development and adulthood, but the mechanisms underlying astrocyte synaptogenic potential only began to be better understood recently. Currently, new drugs and molecules, including the flavonoids, have been studied as therapeutic alternatives for modulation of cognitive processes in physiological and pathological conditions. However, the cellular targets and mechanisms of actions of flavonoids remain poorly elucidated. In the present study, we investigated the effects of hesperidin on memory and its cellular and molecular targets in vivo and in vitro, by using a short-term protocol of treatment. The novel object recognition test (NOR) was used to evaluate memory performance of mice intraperitoneally treated with hesperidin 30 min before the training and again before the test phase. The direct effects of hesperidin on synapses and astrocytes were also investigated using in vitro approaches. Here, we described hesperidin as a new drug able to improve memory in healthy adult mice by two main mechanisms: directly, by inducing synapse formation and function between hippocampal and cortical neurons; and indirectly, by enhancing the synaptogenic ability of cortical astrocytes mainly due to increased secretion of transforming growth factor beta-1 (TGF-β1) by these cells. Our data reinforces the known neuroprotective effect of hesperidin and, by the first time, characterizes its synaptogenic action on the central nervous system (CNS), pointing astrocytes and TGF-β1 signaling as new cellular and molecular targets of hesperidin. Our work provides not only new data regarding flavonoid’s actions on the CNS but also shed light on possible new therapeutic alternative based on astrocyte biology.

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Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice

Abstract: This study demonstrated a protective effect of hesperidin on the neurotoxicity induced by 6-OHDA in aged mice, indicating that it could be useful as a therapy for the treatment of PD.

Cited by 117 publications

References 49 publications

Hesperidin Alleviates Oxidative Stress and Upregulates the Multidrug Resistance Protein 2 in Isoniazid and Rifampicin‐Induced Liver Injury in Rats

Hesperidin Alleviates Oxidative Stress and Upregulates the Multidrug Resistance Protein 2 in Isoniazid and Rifampicin‐Induced Liver Injury in Rats

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1

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