2010
DOI: 10.1016/j.bjps.2009.01.018
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Protective effect of grape seed extract against ischaemia/reperfusion injury in a rat epigastricflap model

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Cited by 25 publications
(16 citation statements)
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“…Antioxidants are potential candidates for prevention or treatment of disorders involving oxidative stress (11). Antioxidant activities might be a major contributory factor to the role of grape seed polyphenols in ischemic injuries and brain inflammation (17-18). Some reports have shown that active constituents in grape seed extract such as Proantocyanidin inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons (44).…”
Section: Introductionmentioning
confidence: 99%
“…Antioxidants are potential candidates for prevention or treatment of disorders involving oxidative stress (11). Antioxidant activities might be a major contributory factor to the role of grape seed polyphenols in ischemic injuries and brain inflammation (17-18). Some reports have shown that active constituents in grape seed extract such as Proantocyanidin inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons (44).…”
Section: Introductionmentioning
confidence: 99%
“…It yielded a better antioxidant effect than same dosage of Vitamin C (12% vs 19%) or Vitamin E (36% vs 44%) (22). Furthermore, proanthocyanidin has also been reported to have anti-carcinogenic, anti-inflammatory, anti-bacterial, anti-viral, cardioprotective, and immune system stimulant properties by inhibiting phospholipase A2, cyclooxygenase, and lipooxygenase enzymes (22,23). When the MDA and NO levels, which show lipid peroxydation following obstructive jaundice, were compared it was found in our study that both parameters were significantly low in the sham group.…”
Section: Discussionmentioning
confidence: 90%
“…The inhibition level of the superoxide anion and hydroxyl radical by 100 mg/L concentration of grape seed proanthocyanidin extract was found to be 78% and 81%, respectively. It yielded a better antioxidant effect than same dosage of Vitamin C (12% vs 19%) or Vitamin E (36% vs 44%) (22). Furthermore, proanthocyanidin has also been reported to have anti-carcinogenic, anti-inflammatory, anti-bacterial, anti-viral, cardioprotective, and immune system stimulant properties by inhibiting phospholipase A2, cyclooxygenase, and lipooxygenase enzymes (22,23).…”
Section: Discussionmentioning
confidence: 99%
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“…Free-radical scavengers can convert toxic ROS into common and relatively harmless end products. Many antioxidants, such as superoxide dismutase (Manson et al, 1983), grape seed proanthocyanidin extract (Karaaslan et al, 2010), and melatonin (Gurlek et al, 2006), have been used to limit tissue injury. However, strategies that decrease oxidative status intensively may produce unwanted side effects because at low levels ROS function as signaling molecules to regulate apoptosis, cell proliferation and differentiation.…”
Section: Discussionmentioning
confidence: 99%