Protective effect of grape seed extract against ischaemia/reperfusion injury in a rat epigastricflap model

Karaaslan, Önder; Ulusoy, Mustafa Gürhan; Kankaya, Yüksel; Tiftikçioğlu, Yiğit Özer; Koçer, Uğur; Kankaya, Duygu; Karaaslan, Gul Meltem; Tunçer, Serdar; Berktas, Mehmet

doi:10.1016/j.bjps.2009.01.018

Cited by 25 publications

(16 citation statements)

References 33 publications

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“…Antioxidants are potential candidates for prevention or treatment of disorders involving oxidative stress (11). Antioxidant activities might be a major contributory factor to the role of grape seed polyphenols in ischemic injuries and brain inflammation (17-18). Some reports have shown that active constituents in grape seed extract such as Proantocyanidin inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons (44).…”

Section: Introductionmentioning

confidence: 99%

Motor and Cognitive Deficits due to Permanent Cerebral Hypoperfusion/ischemia Improve by Pomegranate Seed Extract in Rats

Hajipour¹,

Sarkaki²,

Mans³

et al. 2014

Pakistan J. of Biological Sciences

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This study aimed to evaluate the effect of two weeks oral administration of Pomegranate Seed Extract (PGSE) on active avoidance memory and motor coordination activities after permanent bilateral common carotid arteries occlusion (2CCAO) in male adult rats. Adult male albino rats of Wistar strain (250 ± 20 g, 3-4 months) were used. Animals were divided into eight groups with 10 in each: (1) Sham operated (Sh); (2) Ischemic (I); (3) Ischemic received 100 mg kg(-1) PGSE, orally (I+E100); (4) Ischemic received 200 mg kg(-1) PGSE, orally (I+E200); (5) Ischemic received 400 mg kg(-1) PGSE, orally (I+E400); (6) Ischemic received 800 mg kg(-1) PGSE, orally (I+ E800); (7) Ischemic received 2 mL kg(-1) normal saline, orally (I+Veh); (8) Sham operated received 400 mg kg(-1) PGSE, orally (Sh+E400). In order to make 2CCAO an animal Cerebral Hypoperfusion Ischemia (CHI) model, carotid arteries were ligatured and then bilaterally cut. To evaluate active avoidance task, Correct Response Percentages (CRP) was measured by Y-maze apparatus and motor coordination activity was evaluated using standard behavioral tests by rotarod apparatus in all the rats. It was found that memory. Memory and motor coordination activities were significantly impaired in the rats after CHI (p < 0.01). PGSE treatment significantly improved impairment of memory and motor coordination in the rats with 2CCAO (p < 0.001). PGSE exhibited therapeutic potential for memory and muscular coordination, which was most likely related at least in some part to its antioxidative and free radical scavenging actions.

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Section: Introductionmentioning

confidence: 99%

Motor and Cognitive Deficits due to Permanent Cerebral Hypoperfusion/ischemia Improve by Pomegranate Seed Extract in Rats

Hajipour¹,

Sarkaki²,

Mans³

et al. 2014

Pakistan J. of Biological Sciences

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“…It yielded a better antioxidant effect than same dosage of Vitamin C (12% vs 19%) or Vitamin E (36% vs 44%) (22). Furthermore, proanthocyanidin has also been reported to have anti-carcinogenic, anti-inflammatory, anti-bacterial, anti-viral, cardioprotective, and immune system stimulant properties by inhibiting phospholipase A2, cyclooxygenase, and lipooxygenase enzymes (22,23). When the MDA and NO levels, which show lipid peroxydation following obstructive jaundice, were compared it was found in our study that both parameters were significantly low in the sham group.…”

Section: Discussionmentioning

confidence: 90%

“…The inhibition level of the superoxide anion and hydroxyl radical by 100 mg/L concentration of grape seed proanthocyanidin extract was found to be 78% and 81%, respectively. It yielded a better antioxidant effect than same dosage of Vitamin C (12% vs 19%) or Vitamin E (36% vs 44%) (22). Furthermore, proanthocyanidin has also been reported to have anti-carcinogenic, anti-inflammatory, anti-bacterial, anti-viral, cardioprotective, and immune system stimulant properties by inhibiting phospholipase A2, cyclooxygenase, and lipooxygenase enzymes (22,23).…”

Section: Discussionmentioning

confidence: 99%

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Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice

et al. 2017

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“…Free-radical scavengers can convert toxic ROS into common and relatively harmless end products. Many antioxidants, such as superoxide dismutase (Manson et al, 1983), grape seed proanthocyanidin extract (Karaaslan et al, 2010), and melatonin (Gurlek et al, 2006), have been used to limit tissue injury. However, strategies that decrease oxidative status intensively may produce unwanted side effects because at low levels ROS function as signaling molecules to regulate apoptosis, cell proliferation and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

Zhao

Wang

Qin

et al. 2013

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Skin damage induced by ischemia/reperfusion (I/R) is a multifactorial process that often occurs in plastic surgery. The mechanisms of I/R injury include hypoxia, inflammation, and oxidative damage. Hydrogen gas has been reported to alleviate cerebral I/R injury by acting as a free radical scavenger. Here, we assessed the protective effect of hydrogen-rich saline (HRS) on skin flap I/R injury. Methods: Abdominal skin flaps of rats were elevated and ischemia was induced for 3 h; subsequently, HRS or physiological saline was administered intraperitoneally 10 min before reperfusion. On postoperative Day 5, flap survival, blood perfusion, the accumulation of reactive oxygen species (ROS), and levels of cytokines were evaluated. Histological examinations were performed to assess inflammatory cell infiltration. Results: Skin flap survival and blood flow perfusion were improved by HRS relative to the controls. The production of malondialdehyde (MDA), an indicator of lipid peroxidation, was markedly reduced. A multiplex cytokine assay revealed that HRS reduced the elevation in the levels of inflammatory cytokines, chemokines and growth factors, with the exception of RANTES (regulated on activation, normal T-cell expressed and secreted) growth factor. HRS treatment also reduced inflammatory cell infiltration induced by I/R injury. Conclusions: Our findings suggest that HRS mitigates I/R injury by decreasing inflammation and, therefore, has the potential for application as a therapy for improving skin flap survival.

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Protective effect of grape seed extract against ischaemia/reperfusion injury in a rat epigastricflap model

Cited by 25 publications

References 33 publications

Motor and Cognitive Deficits due to Permanent Cerebral Hypoperfusion/ischemia Improve by Pomegranate Seed Extract in Rats

Motor and Cognitive Deficits due to Permanent Cerebral Hypoperfusion/ischemia Improve by Pomegranate Seed Extract in Rats

Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice

Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

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