Protective effect of ginsenoside Re on acute gastric mucosal lesion induced by compound 48/80

Lee, Sena; Kim, Myung-Gyou; Ko, Sung Kwon; Kim, Hye Kyung; Leem, Kang Hyun; Kim, Youn-Jung

doi:10.1016/j.jgr.2013.10.001

Cited by 29 publications

(15 citation statements)

References 31 publications

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“…and ginsenosides in Panax quinquefolius L. and Panax ginseng C.A. Meyer [3]. Their pharmacological activities, including anti-inflammatory [4], hypoglycemic [5], immunological adjuvant [6], and anti-endotoxin [7] properties, have been well studied.…”

Section: Introductionmentioning

confidence: 99%

Fast separation of triterpenoid saponins using supercritical fluid chromatography coupled with single quadrupole mass spectrometry

Huang

Zhang

Zhou

et al. 2016

Journal of Pharmaceutical and Biomedical Analysis

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a b s t r a c tTriterpenoid saponins (TSs) are the most important components of some traditional Chinese medicines (TCMs) and have exhibited valuable pharmacological properties. In this study, a rapid and efficient method was developed for the separation of kudinosides, stauntosides and ginsenosides using supercritical fluid chromatography coupled with single quadrupole mass spectrometry (SFC-MS). The separation conditions for the selected TSs were carefully optimized after the initial screening of eight stationary phases. The best compromise for all compounds in terms of chromatographic performance and MS sensitivity was obtained when water (5-10%) and formic acid (0.05%) were added to the supercritical carbon dioxide/MeOH mobile phase. Beside the composition of the mobile phase, the nature of the make-up solvent for interfacing SFC with MS was also evaluated. Compared to reversed phase liquid chromatography, the SFC approach showed higher resolution and shorter running time. The developed SFC-MS methods were successfully applied to the separation and identification of TSs present in Ilex latifolia Thunb., Panax quinquefolius L. and Panax ginseng C.A. Meyer. These results suggest that this SFC-MS approach could be employed as a useful tool for the quality assessment of natural products containing TSs as active components.

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Section: Introductionmentioning

confidence: 99%

Fast separation of triterpenoid saponins using supercritical fluid chromatography coupled with single quadrupole mass spectrometry

Huang

Zhang

Zhou

et al. 2016

Journal of Pharmaceutical and Biomedical Analysis

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“…Recent studies have reported that the ginseng berry also exhibits anti-cancer activity in in vitro [2, [73][74][75][76][77] and in vivo [2, 78,79], as well as the ability to attenuate chemotherapy-induced side effects [80,81]; these effects result from the promotion of dendrite cell maturation. Interestingly, the ginseng berry induced a higher degree of co-stimulatory molecule up regulation than the root extract at the same concentrations [82].…”

Section: Anti-cancer Activitymentioning

confidence: 99%

Ginseng Berry, a Promising Anti-Aging Strategy: Recent Opinions on the Biological Effects of a Traditional Korean Ingredient

Seo¹

2016

JARB

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Journal of Advanced Research in Biotechnology Open Access Review Article Introduction: Ginseng and the Ginseng berryGinseng (Panax ginseng) is a popular herbal medicine that has been used in Asia for 5,000 years [1]. Ginseng is classified as fresh, white, or red ginseng, depending on the processing method. As a traditional herb, red ginseng is known as an adaptogen that restores and improves normal well-being. The use of this herbal plant has been widespread throughout the world because of its therapeutic effects. The well-known biochemical and pharmacological effects include anti-cancer [2], anti-fatigue [3], and anti-diabetic effects [4], along with promoting the synthesis of DNA, RNA and proteins [5]. The herb is used as a tea, an extract, or raw directly from powdered root [6]. The representative bioactive compounds are widely considered to begin senosides, which are ginseng-specific saponins [7]. Currently, more than 100 naturally occurring saponins of various types and products of enzymatic conversion have been isolated from the roots, stems, leaves, flowers, berries, and seeds of ginseng. The different parts of ginseng contain distinct ginsenoside profiles, and thus, different parts probably possess different pharmacological effects [8].Recently, many health reports have recommended an increase in fruit intake as part of a healthy dietary pattern [9,10]. These reports allow for various forms of fruit, including fresh, frozen, and dried, as well as juices, and recommend fruits such as oranges, apples, bananas, grapes, raisins, and berries. Whereas berries are known as a good source of potassium or fiber, recent studies suggest that berry fruits are a rich source of many phytochemicals that have a broad spectrum of bioactivity and a positive impact on general health. Several berry fruits, including blackberries, blueberries, cranberries, raspberries, and strawberries, have recently received attention as a result of their effects in vitro and their associations with lowered risks for some chronic diseases, which were found in recent observational research [11,12]. As a perennial herb, ginseng develops flowers and fruits that bloom in its third and fourth year. Unlike the widely used ginseng root, the ginseng berry is preserved for planting and has not been used by general populations. A recent study reported that the ginseng leaf and berry have higher levels of ginsenosides than ginseng root, and their pharmacological activities have also been reported [13]. In this review, we will summarize the research on the role of dietary ginseng berries in delaying aging, as well as evidence suggesting positive biological effects to prevent age-related diseases. Ginseng Berry Bioactive Content and CompositionThe bioactive components of ginseng are triterpene glycosides or saponins, which are commonly regarded as ginsenosides. AbstractA recent effort in the development of new medications and immune modulatory agents is to search for candidates among natural products because they have relatively low toxicities in clinica...

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“…Ginsenosides (GS) is a group of active compounds present in the ginseng (Oh et al, 2014) and was reported to protect the ginseng root from microbial and fungal infections (Wu et al, 2014). Numerous studies showed that GS have a number of biological effects, including antioxidant and antihyperlipidaemic efficacies in streptozotocin-induced diabetic (Cho et al, 2006); protective effect on acute mucosal lesion (Lee et al, 2014); anti-amnestic, antiageing and antistress effects (Cheng et al, 2005); antiallergic activity (Bae et al, 2002); lowering cholesterol and protecting body from lethal infection of haemagglutinating virus (Yoo et al, 2013); protective benefits against neurotoxicity (Li et al, 2011); and metastasis of cancer cells (Yoon et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of ginsenosides using polymerised whey protein (PWP) as wall material and its application in probiotic fermented milk

Wang

Gao

Zheng

et al. 2017

Int J of Food Sci Tech

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Summary Ginsenosides was microencapsulated using heat‐induced polymerised whey protein as wall material. The entrapment yield was 95.46 ± 1.95% and release rates were about 20% and 100% in gastric and intestine juices, respectively. Microencapsulated ginsenosides (0.03% ginsenosides, w/v) were used for fermented milk formulation. Samples with microencapsulated ginsenosides had much higher acceptability compared with those with ginsenoside extract (P < 0.01). Addition of microencapsulated ginsenosides significantly decreased the syneresis of the sample (P < 0.01). The probiotics remained above 106 CFU mL−1 during the first 6 weeks, and no significant difference was observed in probiotics population during 10‐week storage for all samples. SEM micrograph revealed that addition of microcapsules did not change the structure of the samples considerably. The polymerised whey protein‐based microencapsulation might be an effective technique to deliver ginsenosides to small intestine through stomach. It also masked bitter taste and improved the colour of the fermented milks containing ginsenosides.

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Protective effect of ginsenoside Re on acute gastric mucosal lesion induced by compound 48/80

Cited by 29 publications

References 31 publications

Fast separation of triterpenoid saponins using supercritical fluid chromatography coupled with single quadrupole mass spectrometry

Fast separation of triterpenoid saponins using supercritical fluid chromatography coupled with single quadrupole mass spectrometry

Ginseng Berry, a Promising Anti-Aging Strategy: Recent Opinions on the Biological Effects of a Traditional Korean Ingredient

Microencapsulation of ginsenosides using polymerised whey protein (PWP) as wall material and its application in probiotic fermented milk

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