Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats

El-Sharaky, A.S.; Newairy, Al-Sayeda A.; Kamel, Maher A.; Eweda, Saber M.

doi:10.1016/j.fct.2009.04.005

Cited by 104 publications

(94 citation statements)

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“…Several reviews on medicinal values of ginger have been intensively reported in the literature (Ali et al 2008;Grzanna et al 2005;Ernst and Pittler 2000). Several recent studies reported the protective effects of ginger extracts against alcohol induced toxicity (Ali and Fahmy 2009), bromobenzene induced hepatotoxicity (El-sharaky et al 2009), fenitrothion or lead induced developmental toxicity (Farag et al 2010), fungicide induced liver toxicity (Sakr 2007), ethionine-induced toxicity (Habib et al 2008), acetic acid-induced ulcerative colitis (El-abhar et al 2008). Recent studies have also been reported the curing effects of ginger on diseases such as diabetes, cancer and heart attack and it was also found that ginger therapy is more effective in detoxification of cadmium and mercury toxicity (Egwurugwu et al 2007;Vitalis et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Ameliorating activity of ginger (Zingiber officinale) extract against lead induced renal toxicity in male rats

et al. 2011

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Lead poisoning has been known to be associated with structural and functional abnormalities of multiple organ systems of human body. The aim of this investigation was to study the renal protective effects of ginger (Zingiber officinale) extract in lead induced toxicity rats. In this study renal glutathione (GSH) level, glutathione peroxidase (GPX), glutathione-s-transferase (GST), and catalase enzymes were measured in lead nitrate (300 mg/kg BW), and lead nitrate plus ginger extract (150 mg/kg BW) treated rat groups for 1 week and 3 weeks respectively. The glutathione level and GSH dependent antioxidant enzymes such as glutathione peroxidase, glutathione-stransferase, and catalase significantly (P<0.05) increased in ginger extract treated rat groups. In addition, histological studies showed lesser renal changes in lead plus ginger extract treated rat groups than that of lead alone treated rat groups. These results indicate that ginger extract alleviated lead toxic effects by enhancing the levels of glutathione, glutathione peroxidase, glutathiones-transferase and catalase.

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Section: Introductionmentioning

confidence: 99%

Ameliorating activity of ginger (Zingiber officinale) extract against lead induced renal toxicity in male rats

et al. 2011

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Section: Ginger Protects Against Bromobenzene-induced Hepatotoxicitymentioning

confidence: 99%

“…Unfortunately, the exposure to bromobenzene causes neuro and hepatoxicity, and this limits its industrial use [16]. Studies by El-Sharaky [16] have shown that the administration of the ethanolic extract of ginger (100, 200, 300 mg/kg b.wt) two weeks prior to one week of bromobenzene (460 mg/ kg b.wt) was effective in reducing the hepatoxic effects of the toxicant. Ginger mediated the beneficial effects by increasing the levels of the antioxidant enzymes, reducing the toxicant-induced production of nitric oxide metabolites, the cyclooxygenase-2 and the caspase-3 [16].…”

Section: Ginger Protects Against Bromobenzene-induced Hepatotoxicitymentioning

confidence: 99%

“…Bromobenzene, an aryl halide formed by electrophilic aromatic substitution of benzene using bromine, is a very useful industrial solvent, and is widely used as an additive to motor oils [16]. Unfortunately, the exposure to bromobenzene causes neuro and hepatoxicity, and this limits its industrial use [16].…”

Section: Ginger Protects Against Bromobenzene-induced Hepatotoxicitymentioning

confidence: 99%

“…Scientific studies carried out in accordance to the principles of modern system of medicine have convincingly shown that ginger possesses numerous health benefits like antimicrobial, antiviral, gastroprotective, antidiabetic, anti-hypertensive, cardioprotective, anticancer, chemopreventive and immunomodulatory effects [1,4]. Additionally, preclinical studies carried out with laboratory animals have also shown that ginger to possess hepatoprotective effects, and to protect the liver against the toxic effects of diverse class of xenobiotic agents like alcohol [8,9], country liquor [10], acetaminophen [11], heavy metals [12,13], CCl 4 [14], paraben [15] and bromobenzene [16]. In the following section, the observations from these studies will be addressed in detail.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ginger Protects the Liver against the Toxic Effects of Xenobiotic Compounds: Preclinical Observations

Haniadka¹,

Saxena²,

Shivashankara³

et al. 2013

J Nutr Food Sci

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According to the World Health Organization, chronic liver disease is a major ailment and causes significant morbidity and mortality in both western and developing countries. However, till date no ideal hepatoprotective agents are available in the modern system of medicine to effective prevent and cure liver ailments. This has necessitated the need to depend on complementary and alternative systems of medicine for liver ailments and diseases. Zingiber officinale Roscoe commonly known as ginger is arguably one of the most commonly used spice, and is an integral part of our diet. In addition to its dietary use, ginger is also reported to possess myriad health benefits, and has been used in the various traditional and folk systems of medicine to treat various ailments and illnesses. Preclinical studies carried out in the past decade have shown that ginger possesses hepatoprotective effects, and to protect against diverse xenobiotic compounds like alcohol, acetaminophen, fungicides, tetracycline, heavy metals and organophosphorus compounds. Mechanistic studies have shown that the protective actions are mediated through free radical scavenging, antioxidant, cytoprotective, and to modulate the levels of the detoxifying enzymes. This review for the first time summarizes the results related to the beneficial properties of ginger in ameliorating the toxic effects of hepatotoxins, and also emphasizes the aspects that warrant future research to establish its activity and utility as a broad spectrum hepatoprotective agent.

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Toxicological effects of pet food ingredients on canine bone marrow‐derived mesenchymal stem cells and enterocyte‐like cells

Ortega

Jeffery²,

Riviere

et al. 2015

J of Applied Toxicology

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We developed an in vitro method to assess pet food ingredients safety. Canine bone marrow-derived mesenchymal stem cells (BMSC) were differentiated into enterocyte-like cells (ELC) to assess toxicity in cells representing similar patterns of exposure in vivo. The toxicological profile of clove leave oil, eugenol, guanosine monophosphate (GMP), GMP + inosine monophosphate, sorbose, ginger root extract, cinnamon bark oil, cinnamaldehyde, thyme oil, thymol and citric acid was assessed in BMSC and ELC. The LC50 for GMP + inosine monophosphate was 59.42 ± 0.90 and 56.7 ± 3.5 mg ml(-1) for BMSC and ELC; 56.84 ± 0.95 and 53.66 ± 1.36 mg ml(-1) for GMP; 0.02 ± 0.001 and 1.25 ± 0.47 mg ml(-1) for citric acid; 0.077 ± 0.002 and 0.037 ± 0.01 mg ml(-1) for cinnamaldehyde; 0.002 ± 0.0001 and 0.002 ± 0.0008 mg ml(-1) for thymol; 0.080 ± 0.003 and 0.059 ± 0.001 mg ml(-1) for thyme oil; 0.111 ± 0.002 and 0.054 ± 0.01 mg ml(-1) for cinnamon bark oil; 0.119 ± 0.0004 and 0.099 ± 0.011 mg ml(-1) for clove leave oil; 0.04 ± 0.001 and 0.028 ± 0.002 mg ml(-1) for eugenol; 2.80 ± 0.11 and 1.75 ± 0.51 mg ml(-1) for ginger root extract; > 200 and 116.78 ± 7.35 mg ml(-1) for sorbose. Lemon grass oil was evaluated at 0.003-0.9 in BMSC and .03-0.9 mg ml(-1) in ELC and its mechanistic effect was investigated. The gene toxicology studies showed regulation of 61% genes in CYP450 pathway, 37% in cholestasis and 33% in immunotoxicity pathways for BMSC. For ELC, 80% for heat shock response, 69% for beta-oxidation and 65% for mitochondrial energy metabolism. In conclusion, these studies provide a baseline against which differential toxicity of dietary feed ingredients can be assessed in vitro for direct effects on canine cells and demonstrate differential toxicity in differentiated cells that represent gastrointestinal epithelial cells.

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Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats

Cited by 104 publications

References 50 publications

Ameliorating activity of ginger (Zingiber officinale) extract against lead induced renal toxicity in male rats

Ameliorating activity of ginger (Zingiber officinale) extract against lead induced renal toxicity in male rats

Ginger Protects the Liver against the Toxic Effects of Xenobiotic Compounds: Preclinical Observations

Toxicological effects of pet food ingredients on canine bone marrow‐derived mesenchymal stem cells and enterocyte‐like cells

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