Protective effect of garlic extract against maternal and foetal cerebellar damage induced by lead administration during pregnancy in rats

Saleh, Hamid A; El-Aziz, G S Abdel; Mustafa, Hesham N.; Saleh, A H A; Mal, A O; Deifalla, Abdel Halim; Aburas, Majdah

doi:10.5603/fm.a2017.0063

Cited by 21 publications

(15 citation statements)

References 40 publications

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“…Additionally, degenerating pyknotic cells and vacuolation in the Purkinje cell layer were easily detected in the Pb group. Similarly, previous studies reported that Pb exposure during cerebellar development significantly decreased the number of Purkinje cells and ascorbic acid treatment mitigated Pb-induced impairments in the PA group [17,20,34,35,36]. Our results are consistently similar with previous studies, which observed that ascorbic acid prevents the harmful effects of other heavy metals including mercury and cadmium on brain development [37,38].…”

Section: Discussionsupporting

confidence: 92%

Effects of Ascorbic Acid on Osteopontin Expression and Axonal Myelination in the Developing Cerebellum of Lead-Exposed Rat Pups

Nam

Seo

Nahm

et al. 2019

IJERPH

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Osteopontin (OPN) is a multi-functional protein that binds to integrin and calcium-binding phosphoprotein. OPN is required for normal neuronal development and its axonal myelination. We studied the combined effect of lead (Pb) and ascorbic acid treatment on OPN expression in the developing cerebellum. We randomly divided pregnant female rats into three groups: control, Pb (lead acetate, 0.3%, drinking water), and Pb plus ascorbic acid (PA; ascorbic acid, 100 mg/kg, oral intubation) groups. The blood level of Pb was significantly increased, while ascorbic acid reduced Pb levels in the dams and pups. At postnatal day (PND) 21, results from Nissl staining and OPN immunohistochemistry demonstrated that OPN was detected in the Purkinje cell layer in the cerebellum. Ascorbic acid treatment mitigated Pb exposure-induced reduction in the number of intact Purkinje cells and OPN immunoreactive Purkinje cells in the cerebellum of pups. In addition, Pb-induced reduction in the number of oligodendrocytes and myelin-associated glycoprotein is associated with the malformation of the myelin sheath. Ascorbic acid provided protection from Pb-induced impairments. Pb-induced structural deficits in the cerebellum resulted in functional deterioration observed during locomotive tests (bar holding test and wire mesh ascending test), while ascorbic acid ameliorated these harmful effects. Present results suggest that the change of OPN is associated with myelination in the developing cerebellum. The results also demonstrated that exposure to Pb is harmful, while ascorbic acid treatment is beneficial.

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Section: Discussionsupporting

confidence: 92%

Effects of Ascorbic Acid on Osteopontin Expression and Axonal Myelination in the Developing Cerebellum of Lead-Exposed Rat Pups

Nam

Seo

Nahm

et al. 2019

IJERPH

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“…The findings suggested that garlic may protect against lead-induced neuronal cell apoptosis in the developing hippocampus of rat pups [ 45 ]. The beneficial effects of this natural antioxidant in protecting against lead toxicity were also noted in other studies [ 46 , 47 ]. Co-administration of lead (at a dose of 160 and 320 mg/kg bw) with garlic extract (250 mg/kg bw) to pregnant rats resulted in reductions in lead levels not only in the mother’s blood but also in the cerebellum, placenta, and fetal brain [ 47 ].…”

Section: Herbal Medicines Used To Counteract Infections During Pregnancysupporting

confidence: 75%

“…The beneficial effects of this natural antioxidant in protecting against lead toxicity were also noted in other studies [ 46 , 47 ]. Co-administration of lead (at a dose of 160 and 320 mg/kg bw) with garlic extract (250 mg/kg bw) to pregnant rats resulted in reductions in lead levels not only in the mother’s blood but also in the cerebellum, placenta, and fetal brain [ 47 ]. In immunohistochemical staining, a reduction in the number of Purkinje cells in the cerebellum was observed in the group of animals exposed to lead.…”

Section: Herbal Medicines Used To Counteract Infections During Pregnancysupporting

confidence: 75%

Herbal Medicines—Are They Effective and Safe during Pregnancy?

Sarecka-Hujar

Szulc-Musioł

2022

Pharmaceutics

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Since the teratogenicity of Thalidomide has been proven, herbal products are more commonly used in pregnancy to not only relieve morning sickness but also to fight infections. These products are frequently considered as natural and therefore harmless. However, herbs contain a number of active substances that, when used during pregnancy, can affect the development of the fetus. Often, pregnant women do not consult the usage of herbal medicines with a physician. The access to these products is easy and treatment of certain ailments with the use of herbs is common in many countries. The aim of the present literature review was to discuss available data regarding the efficacy and safety of cranberry, chamomile, Echinacea purpurea, garlic, ginger, Ginkgo biloba, and peppermint, which are used to counteract the most common ailments during pregnancy, i.e., infections and pregnancy-related ailments (e.g., nausea and vomiting, dizziness, and headache). Analysis of available data showed that ginger is one of the most extensively analyzed herbal remedies. The dose of ginger below 1000 mg per day may help to relief hypereremesis gravidarum, and such an amount of ginger did not increase frequency of adverse effects for either woman or developing fetus. Data regarding other herbs are most often heterogeneous and give conflicting results with no clear conclusions. However, all herbal products should be used with a special caution in pregnancy. Further high-quality human studies should be determined to confirm the safe doses of herbal products which could be used by pregnant or breast-feeding women.

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“…Previous studies con rmed that CP can penetrate the placental barrier and induce congenital malformation in fetuses [31]. On the other hand, placental transfer of garlic components was recorded by Saleh et al [32].…”

Section: Introductionmentioning

confidence: 95%

Modulatory Role of Garlic (Allium Sativum) Extract Against Cisplatin- Induced Nephrotoxicity In Female Albino Rats And Their Offspring.

El-Beltagy

Mohamed

Akeel

et al. 2022

Preprint

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This work is mainly designed to evaluate the potential therapeutic role of garlic extract against cisplatin induced nephrotoxicity in pregnant rats and their offspring. Twenty-four pregnant rats were used in the current study. They were randomly allocated into four equal groups (n=6): control, garlic, and CP + Garlic group. At the end of the weaning period, the mothers and the offsprings of all groups were sacrificed, the kidneys were immediately excised, and processed for histological and biochemical investigations. Also, blood samples were withdrawn and processed for estimation of the assigned biochemical parameters. The renal histological sections from CP-treated mother rats displayed pronounced histopathological lesions however; their offsprings showed mild renal histopatological lesions if compared with those of their mothers. The levels of renal tissue SOD), CAT and GPx enzymes were significantly decreased .On the contrary, the levels of MDA, serum urea and creatinine were significantly increased in CP-treated mother rats and their offsprings as compared with control. The percentage value of caspase 3 activity was markedly elevated in the renal tissues of CP-treated mother rats and their offspring compared to the control group. Supplementation of garlic extract to the rats of group 4, the over-all histological lesions as well as biochemical parameters were restored nearly to the control ones. It is concluded that garlic (Allium sativum) extract has a powerful ameliorative role against CP induced nephrotoxicity in preganat rats and their offspring.

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Protective effect of garlic extract against maternal and foetal cerebellar damage induced by lead administration during pregnancy in rats

Cited by 21 publications

References 40 publications

Effects of Ascorbic Acid on Osteopontin Expression and Axonal Myelination in the Developing Cerebellum of Lead-Exposed Rat Pups

Effects of Ascorbic Acid on Osteopontin Expression and Axonal Myelination in the Developing Cerebellum of Lead-Exposed Rat Pups

Herbal Medicines—Are They Effective and Safe during Pregnancy?

Modulatory Role of Garlic (Allium Sativum) Extract Against Cisplatin- Induced Nephrotoxicity In Female Albino Rats And Their Offspring.

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