Protective Effect of Fermented Red Ginseng Extracts on Photoaging Skin of Induced by UVB in Hairless Mice

김, 호일; 오, 미진; 김, 종석; 이, 성철; 이, 창현

doi:10.15188/kjopp.2015.02.29.1.58

Cited by 3 publications

(2 citation statements)

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“…As sunlight is a major factor in the development of skin wrinkles, UV irradiation-induced wrinkle models naturally mimic skin wrinkle formation. 17,18) Wrinkling is associated with changes in diverse dermal ECM proteins including collagen types I and II, elastin, proteoglycan, and fibronectin. 19) UV irradiation potentiates excessive ECM degradation in connective tissue and induces its damage, which eventually leads to wrinkle formation.…”

Section: Discussionmentioning

confidence: 99%

Adipose-derived mesenchymal stem cells reduce MMP-1 expression in UV-irradiated human dermal fibroblasts: therapeutic potential in skin wrinkling

Son

Yun

Kim

2015

Bioscience, Biotechnology, and Biochemistry

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Adipose-derived mesenchymal stem cells (AdMSCs) have been reported to have therapeutic benefit in skin. The aim of this study was to examine the effects of AdMSCs in UV-irradiated human dermal fibroblasts (HDFs) for therapeutic potential in skin wrinkling. UV irradiation, a model naturally mimic skin wrinkle formation, is known to increase matrix metalloproteinase-1 (MMP-1), making MMP-1 a target for skin photoaging. Our findings identified that AdMSCs reduce MMP-1 level in UV-irradiated HDFs and increase type 1 procollagen in HDFs. A dose-dependent increase in type 1 procollagen was confirmed by AdMSC-conditioned medium. Importantly, our current findings showing the effects of AdMSCs on the induction of MMP-1 in UV-radiated HDFs and the expression of collagen in HDFs can provide an evidence of relationship between MMP-1 and procollagen production for the protection against wrinkle formation. Collectively, AdMSCs may contribute to anti-wrinkle effects in skin but further experiments are needed to identify the mechanism.

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Section: Discussionmentioning

confidence: 99%

Adipose-derived mesenchymal stem cells reduce MMP-1 expression in UV-irradiated human dermal fibroblasts: therapeutic potential in skin wrinkling

Son

Yun

Kim

2015

Bioscience, Biotechnology, and Biochemistry

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“…http://dx.doi.org/10.20402/ajbc.2016.0055 로 superoxide dismutase (SOD), catalase, L-ascorbic acid, α -tocopherol, flavonoid 등이 있다 (Kim et al, 2015). 소나무(Pinus densiflora)는 낮은 산에서 자라는 상록성 침엽 교목으로 키는 30-40 m로 자라고, 수피가 벗겨지면 적갈색이 되 기 때문에 적송이라고 부른다.…”

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Anti-oxidant and Anti-melanogenic Activity of the Methanol Extract of Pine Cone

Lee¹,

Roh²,

Lee³

et al. 2016

Asian J Beauty Cosmetol

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This study was conducted to evaluate anti-oxidant and anti-melanogenic activities of pine cone extract from Pinus densiflora. Methods: Pine cone extract used in this experiment was extracted with methanol at room temperature for 24 h. Anti-oxidant activities were measured by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and nitro blue tetrazolium chloride (NBT) assay. Moreover, the inhibitory effects of pine cone methanol extract on tyrosinase and melanin synthesis in murine B16-F10 melanoma cells were studied. In addition, cell viability was investigated by MTT assay. Results: The results showed that the pine cone methanol extract strongly reduced the DPPH free radical activity (IC 50 =9.57±1.24 μg/mL). However, its activity was lower than the activity of L-ascorbic acid (positive control, IC 50 =1.28±0.03 μg/mL). In NBT assay, the pine cone methanol extract exhibited more superoxide anion radical scavenging activity (IC 50 =3.33±0.28 μg/mL), compared with L-ascorbic acid (IC 50 =73.25±1.02 μg/mL). When treated with 3,4-Dihydroxy-L-phenylalanine (L-DOPA) as the substrate of tyrosinase, the extract inhibited the tyrosinase activity with an IC 50 value of 106.15±1.69 μg/mL, lower effect than that of kojic acid (IC 50 =3.12±0.68 μg/mL). In murine B16-F10 cells, the pine cone methanol extract significantly suppressed melanogenesis in a concentration-dependent manner without cytotoxicity. Conclusion: The results indicated that pine cone extract could be potentially valuable as a new potent depigmentation agent.

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Antioxidative and Protective Effects of Corn Silk (Zea mays L.) Extract on Human HaCaT Keratinocyte

Kim¹,

Seo²,

서경혜³

et al. 2016

Korean J. Crop Sci.

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Protective Effect of Fermented Red Ginseng Extracts on Photoaging Skin of Induced by UVB in Hairless Mice

Cited by 3 publications

References 0 publications

Adipose-derived mesenchymal stem cells reduce MMP-1 expression in UV-irradiated human dermal fibroblasts: therapeutic potential in skin wrinkling

Adipose-derived mesenchymal stem cells reduce MMP-1 expression in UV-irradiated human dermal fibroblasts: therapeutic potential in skin wrinkling

Anti-oxidant and Anti-melanogenic Activity of the Methanol Extract of Pine Cone

Antioxidative and Protective Effects of Corn Silk (Zea mays L.) Extract on Human HaCaT Keratinocyte

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