Protective effect of fermented aloe extract on glutamate-induced cytotoxicity in HT22 cells

Abstract

Excessive glutamate can cause oxidative stress in neuronal cells and this can significantly contribute to the etiology of neurodegenerative disease. The present study mainly aims to investigate that aloe extract (AE) and fermented aloe extract (FAE) could protect against glutamate-induced cytotoxicity by modulating oxidative stress. In this study, both AE and FAE showed potent neuroprotective activity by inhibiting ROS and Ca 2+ concentration, increasing mitochondria membrane potential, and activating glutathione-related enzymes against glutamate-insulted neurotoxicity in HT22 cells. In addition, the neuroprotective activity of FAE was more potent than that of AE. HPLC analysis reveals that the chemical composition of FAE is different from that of AE. Especially, the contents of aloin A, aloin B and aloenin were higher in FAE than in AE. In conclusion, this study indicates that both AE and FAE may have effective neuroprotective activity in glutamate-insulted pathological conditions such as Alzheimer’s disease by managing oxidative stress.

Neuroprotective effect of ropinirole against Aβ1–42‐induced neurochemical perturbations and cognitive impairments in a rodent model

“…Although the exact pathophysiology of AD is still unclear and remains inconclusive, it is difficult to treat AD, and currently, there is no cure. A limited number of drugs are used to treat dementia, including donepezil, rivastigmine, and galantamine 15,16 . Last few decades, many clinical trials of medicine for AD treatment have failed, and it is urgent to develop a new medicine.…”

“…A limited number of drugs are used to treat dementia, including donepezil, rivastigmine, and galantamine. 15,16 Last few decades, many clinical trials of medicine for AD treatment have failed, and it is urgent to develop a new medicine. Ropinirole (ROP) is a nonergot dopamine agonist used to treat individuals with Parkinson's disease and restless leg syndrome for neurological improvements.…”