Protective Effect of Eupatilin Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice

Lee, H.M.; Jang, Hyuk Jai; Kim, S.S.; Kim, H.J.; Lee, S.Y.; Oh, Moon Young; Kwan, H.C.; Jang, Dae Sik; Eom, Dae-Woon

doi:10.1016/j.transproceed.2016.01.024

Cited by 13 publications

(4 citation statements)

References 23 publications

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“…Cryptotanshinone attenuates serum aminotransferase levels and hepatic IR injury by inhibiting the c‐Jun N‐terminal kinase (JNK) and MAPK signalling pathways . Eupatilin, a pharmacologically active flavone derived from the Artemisia species, promotes the accumulation of HSP and Bcl‐2, attenuates the release of iNOS and cleaves caspase‐3 after hepatic IR . All these Chinese medicines demonstrate protective effects via multiple signalling pathways including calcium resistance, immunosuppression and interference in energy metabolism.…”

Section: Pharmacological Pre‐conditioning Before Hepatic Irmentioning

confidence: 99%

Pre‐conditions for eliminating mitochondrial dysfunction and maintaining liver function after hepatic ischaemia reperfusion

Hu¹

2017

J Cellular Molecular Medi

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The liver, the largest organ with multiple synthesis and secretion functions in mammals, consists of hepatocytes and Kupffer, stem, endothelial, stellate and other parenchymal cells. Because of early and extensive contact with the external environment, hepatic ischaemia reperfusion (IR) may result in mitochondrial dysfunction, autophagy and apoptosis of cells and tissues under various pathological conditions. Because the liver requires a high oxygen supply to maintain normal detoxification and synthesis functions, it is extremely susceptible to ischaemia and subsequent reperfusion with blood. Consequently, hepatic IR leads to acute or chronic liver failure and significantly increases the total rate of morbidity and mortality through multiple regulatory mechanisms. An increasing number of studies indicate that mitochondrial structure and function are impaired after hepatic IR, but that the health of liver tissues or liver grafts can be effectively rescued by attenuation of mitochondrial dysfunction. In this review, we mainly focus on the subsequent therapeutic interventions related to the conservation of mitochondrial function involved in mitigating hepatic IR injury and the potential mechanisms of protection. Because mitochondria are abundant in liver tissue, clarification of the regulatory mechanisms between mitochondrial dysfunction and hepatic IR should shed light on clinical therapies for alleviating hepatic IR‐induced injury.

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Section: Pharmacological Pre‐conditioning Before Hepatic Irmentioning

confidence: 99%

Pre‐conditions for eliminating mitochondrial dysfunction and maintaining liver function after hepatic ischaemia reperfusion

Hu¹

2017

J Cellular Molecular Medi

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“…The 13 compounds detected only in AF included five flavonoids, seven coumarins, and a triterpenoid. With the exception of the pharmacological and clinical effects of the five compounds in AFI listed above [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ], the 13 compounds also exerted other pharmacological activities and clinical effects. Some of them can promote osteogenesis and protect cartilage [ 42 , 43 , 44 , 45 , 46 , 47 ]; eupatilin and osthole can provide significant cardioprotective effects [ 48 , 49 ]; meranzin hydrate can promote intestinal transit and gastric emptying [ 50 ]; conversely, eupatilin can decrease human lower gastrointestinal motility [ 51 ]; eriodictyol can attenuate acute lung injury and kidney injury through its antioxidative and anti-inflammatory activity [ 52 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

Identification and Comparison of Constituents of Aurantii Fructus and Aurantii Fructus Immaturus by UFLC-DAD-Triple TOF-MS/MS

et al. 2018

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Although Aurantii Fructus (AF) and Aurantii Fructus Immaturus (AFI) are both the fruits of the same rutaceae plant at different stages of growth, they exert similar yet distinct clinical effects. The chemical composition is crucial for quality control as well as therapeutic application. To address this concern, it is significant to evaluate the similarities and differences of the constituents in both AF and AFI. The extract of AF and AFI were comprehensively analyzed by ultra fast liquid chromatography-photodiode array detector-triple-time of flight-tandem mass spectrometry (UFLC-DAD-Triple TOF-MS/MS). Among the 40 compounds detected, 19 metabolites were detected in both the AF and AFI; whereas 13 compounds were only detected in AF and five constituents were exclusively detected in AFI. In particular, even in AFI, three compounds were only identified in AFI (Citrus aurantium’ L. and its cultivar). Among the 18 compounds confirmed by standard database, 13 compounds were reported in AF and AFI for the first time. Furthermore, the distinction was also revealed by the content of naringin, hesperidin, neohesperidin, and synephrine. The study directly contributed to the similarities and differences of AF and AFI. Herein, similarities and the differences in chemical profiles of AF and AFI could explain the current clinical applications.

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“…Some methods are available to reduce pneumoperitoneum-induced injury such as ischemic-preconditioning, pneumoperitoneum preconditioning, low intra-abdominal pressure, stepwise rising CO 2 insufflation, melatonin, theophylline, erythropoietin and dexmedetomidine [ 65 – 71 ]. Some agents are also available to reduce ischemia-reperfusion injury such as epigallocatechin-3-gallate, gastrodin, eupatilin and oxymatrine [ 38 , 72 – 74 ]. If H 2 can be used in clinical practice it would be convenient because it is cheaper compared with those methods, although its inhalation may be dangerous because of its inflammable and explosive characteristics.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats

Chen

Jiang

et al. 2017

Oncotarget

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The aim of the current study was to identify the protective effect of hydrogen gas against liver injury during CO2 pneumoperitoneum. Rats were randomly divided into three groups: control group (C group), pneumoperitoneum group (P15 group) and hydrogen group (H2 group). Rats in the C group were subjected to anesthesia for 90 min. Rats in the P15 group received an abdominal insufflation of CO2 for 90 min at an intra-abdominal pressure of 15 mmHg. Rats in the H2 group received a hypodermic injection of hydrogen gas (0.2 mL/kg) and after 10 min they received an abdominal insufflation of CO2 for 90 min at an intra-abdominal pressure of 15 mmHg. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured to evaluate liver function. Malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) content were measured to evaluate oxidative stress. Nuclear factor E2-related factor 2 (Nrf2) and Nrf2 downstream target genes, apoptosis-related genes and inflammatory cytokine mRNA and protein expression were detected. Liver injury was detected under the microscope. Our results revealed that liver function, antioxidants content, inflammation and liver injury were improved after hydrogen preconditioning in H2 group compared with P15 group. Overall, our results revealed that subcutaneous hydrogen injection could exert a protective effect against liver injury during CO2 pneumoperitoneum through reducing oxidative stress, cell apoptosis and inflammatory cytokines release.

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Protective Effect of Eupatilin Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice

Cited by 13 publications

References 23 publications

Pre‐conditions for eliminating mitochondrial dysfunction and maintaining liver function after hepatic ischaemia reperfusion

Pre‐conditions for eliminating mitochondrial dysfunction and maintaining liver function after hepatic ischaemia reperfusion

Identification and Comparison of Constituents of Aurantii Fructus and Aurantii Fructus Immaturus by UFLC-DAD-Triple TOF-MS/MS

Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats

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