Protective Effect of Etomidate on Spinal Cord Ischemia–Reperfusion Injury Induced by Aortic Occlusion in Rabbits

Yu, Qijing; Zhou, Qingshan; Huang, Haibo; Wang, Yanlin; Tian, Shufang; Duan, Daiming

doi:10.1016/j.avsg.2009.06.023

Cited by 13 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Etomidate, a short-acting anesthetic drug, has been used in an IR injury rabbit model in a study investigating its neuroprotective effect [29]. In that study, etomidate was found to have a potent neuroprotective effect against IRinduced spinal cord injuries.…”

Section: Discussionmentioning

confidence: 98%

Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model

Harman¹,

Hastürk

Yaman³

et al. 2012

Childs Nerv Syst

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model

Harman¹,

Hastürk

Yaman³

et al. 2012

Childs Nerv Syst

View full text Add to dashboard Cite

show abstract

“…Yu et al found that etomidate had a protective effect on ischemia-reperfusion injury of the spinal cord induced by interruption of the rabbit aorta (15). Ergün et al found that anesthetic doses of propofol, ketamine, and etomidate had protective effects on ischemia-reperfusion injury of skeletal muscle, and there were no obvious differences between them (16).…”

Section: Discussionmentioning

confidence: 99%

Effect of etomidate on the oxidative stress response and levels of inflammatory factors from ischemia-reperfusion injury after tibial fracture surgery

Fan

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

The effect of etomidate on the oxidative stress response and levels of inflammatory factors resulting from ischemia-reperfusion injury of the lower extremities during tibial fracture surgery were investigated. From December 2013 to June 2015, 60 tibial fracture patients with surgical indications for open reduction and internal fixation were selected. Patients were randomly divided into the observation group and the control group. All patients were stanched by tourniquet hemostasis. Patients in the observation group were anesthetized with etomidate (3–6 mg/kg·h) + remifentanil (0.1–0.25 µg/kg/min) administered with an injection pump to maintain intraoperative sedation and analgesia anesthesia. Patients in the control group received propofol (3–6 mg/kg·h) + remifentanil (0.1–0.25 µg/kg/min). Before surgery (T0), before surgery was completed and anesthesia was stopped (T1), 24 h after surgery (T3), 48 h after surgery (T4), and 1 week after surgery (T5), serum superoxide dismutase (SOD) activity was determined with a kit, and ELISA was used to measure the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1, and IL-6 in peripheral blood from both groups of patients. Surgery in both groups was completed smoothly. We found that serum SOD levels of patients in the observation group were significantly higher than those of the control group, while the levels of TNF-α, IL-1, and IL-6 released by neutrophils were significantly decreased after ischemia-reperfusion injury (P<0.05). Postoperative length of stay in hospital of the observation group was significantly shorter and the occurrence rate of anesthesia complications was significantly lower than in the control group (P<0.05). In conclusion, during surgery for lower limb fracture, the use of etomidate for maintaining sedation can effectively maintain serum SOD activity and inhibit the release of inflammatory factors after ischemia-reperfusion injury of the fracture, to reduce the occurrence rate of anesthesia complications after surgery.

show abstract

“…There is limited literature showing the neuroprotective activity of etomidate (5,32). Although there have been studies about the decrease of functional and histologic deficits by etomidate administration after SCI (8,27,31), in this study these useful benefits were not reflected on the clinical practice.…”

Section: █ Conclusionmentioning

confidence: 80%

Comprasion of etanercept, etomidate and erythropoietin and their combinations in experimentally induced spinal cord injury

Çalışkan

Simsek²,

Vural³

et al. 2015

Turkish Neurosurgery

View full text Add to dashboard Cite

ABSTRACTincludes neurons, axons, and blood vessels at the affected site and causes hemorrhage, vasoconstriction and ischemia. After the primary mechanical injury, there is a complex secondary injury cascade including vascular disturbances, calcium-mediated cellular injury, free radical generation, mATERIAl and mEThODS: 85 healthy female Wistar-Albino rats were used in this study. Rats were divided 8 trauma groups that consisted of 10 rats for each, and 5 rats for the sham group. Laminectomy was performed under general anesthesia and the spinal cord was exposed with intact dura mater, and injury was created by the clip compression model. After the spinal cord injury, drugs were administered immediately intraperitoneally or subcutaneously. except the sham group, all groups received drugs and were observed 24 or 72 hours. At the 72 nd hour each group was anesthesized and somatosensorial evoked potentials (SeP) were recorded from the interarcuate ligament from the 2 vertebra proximal to the injured spinal cord and spinal cord tissue samples were taken for histopathological and biochemical evaluation.RESUlTS: etomidate groups showed a lower effect on spinal cord injury than etanercept and erythropoietin in terms of clinical, SEP and TNF-α. Etanercept and erythropoietin's neuroprotective effectiveness was shown alone or in combination treatments. More meaningful results were achieved with the use of erythropoietin and etanercept combination after spinal cord injury (SCI) than using erythropoietin alone. After SCI, highest Basso, Beattie, and Bresnahan (BBB) scores were achieved in the group which etanercept and erythropoietin applied together. CONClUSION:The neuroprotective activity of etomidate was suspect. The neuroprotective effect of etanercept and erythropoietin after SCI was shown in individual and combined applications in this study. However, more experimental studies are needed for clinical use.

show abstract

Protective Effect of Etomidate on Spinal Cord Ischemia–Reperfusion Injury Induced by Aortic Occlusion in Rabbits

Cited by 13 publications

References 32 publications

Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model

Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model

Effect of etomidate on the oxidative stress response and levels of inflammatory factors from ischemia-reperfusion injury after tibial fracture surgery

Comprasion of etanercept, etomidate and erythropoietin and their combinations in experimentally induced spinal cord injury

Contact Info

Product

Resources

About