Protective Effect of Esculin on Streptozotocin-Induced Diabetic Renal Damage in Mice

Kang, Ki Sung; Lee, Woojung; Jung, Yujung; Lee, Ji Hwan; Lee, Seungyong; Eom, Dae-Woon; Jeon, Youngsic; Yoo, Hye Hyun; Jin, Ming; Song, Kyung Il; Kim, Won Jun; Ham, Jungyeob; Kim, Hyoung Ja; Kim, Su‐Nam

doi:10.1021/jf403840c

Cited by 57 publications

(31 citation statements)

References 35 publications

(44 reference statements)

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“…Additionally, esculin showed wide pharmacological activities against different diseases, such as cognitive impairment in experimental diabetic nephropathy where it exhibited a strong anti-inflammatory activity marked by the suppressed p38 MAPK and JNK [142]. In models of streptozotocin-induced renal damage in diabetic mice [143], cold-restrained stress and pylorus ligation-induced ulcer [144], ethanol-induced gastric lesion [145], and LPS/D-galactosamine-induced acute liver injury [146], esculin significantly ameliorated inflammation evidenced by the suppressed TNF-α, IL-1β, and MPO. Li et al reported the protective role of esculin against LPS-induced macrophages and endotoxin shock in mice and NO production in vitro.…”

Section: Urolithin Amentioning

confidence: 99%

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Hassanein

Sayed

Hussein

et al. 2020

Oxidative Medicine and Cellular Longevity

157

106

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The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes. Nrf2 has a powerful anti-inflammatory activity mediated via modulating NF-κB. Therefore, pharmacological activation of Nrf2 is a promising therapeutic strategy for the treatment/prevention of several diseases that are underlined by both oxidative stress and inflammation. Coumarins are natural products with promising pharmacological activities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory efficacies. Coumarins are found in many plants, fungi, and bacteria and have been widely used as complementary and alternative medicines. Some coumarins have shown an ability to activate Nrf2 signaling in different cells and animal models. The present review compiles the research findings of seventeen coumarin derivatives of plant origin (imperatorin, visnagin, urolithin B, urolithin A, scopoletin, esculin, esculetin, umbelliferone, fraxetin, fraxin, daphnetin, anomalin, wedelolactone, glycycoumarin, osthole, hydrangenol, and isoimperatorin) as antioxidant and anti-inflammatory agents, emphasizing the role of Nrf2 activation in their pharmacological activities. Additionally, molecular docking simulations were utilized to investigate the potential binding mode of these coumarins with Keap1 as a strategy to disrupt Keap1/Nrf2 protein-protein interaction and activate Nrf2 signaling.

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Section: Urolithin Amentioning

confidence: 99%

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Hassanein

Sayed

Hussein

et al. 2020

Oxidative Medicine and Cellular Longevity

157

106

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“…Free radicals ROS and RNS could disrupt the physiological function of various tissues and possibly caused damage in the kidney. Kim et al [23] stated that the elevation of ROS and pro-inflammation cytokine levels played an important role in damaging glomeruli, tubules and blood vessels. Study results from Zafar et al [24] showed that diabetic rats (Rattus norvegicus) induced with a single-dose STZ injection on a 45 mg/kg body weight dose were found to have necrosis on their tubules, glomerulosclerosis, tubular atrophy, and a thickening of the glomerular membrane.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice

Husen¹,

Khaleyla²,

Ansori³

et al. 2018

Proceedings of the 1st International Conference Postgraduate School Universitas Airlangga : "Implementation of Climate Change A

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Abstract-This research was aimed to investigate the ability of a alpha-mangostin compound derived from mangosteen pericarp to reduce plasma blood urea nitrogen (BUN) and creatinine level, and also to ameliorate the damaged renal proximal tubular of the kidneys in diabetic mice. An in-vivo antioxidant test was conducted using male BALB/c mice. The mice were divided into two groups; normal control (KN) and streptozotocin-induced diabetic mice. Streptozotocin (STZ) induction was performed using multiple low-doses of 30 mg/kg injected for five consecutive days. The diabetic mice were separated again into three sub-groups; diabetic control (KD), diabetic mice treated with Metformin HCl (KM), and diabetic mice treated with alpha-mangostin. The alpha-mangostin treatment group was categorised based on the dose given; P1 (2 mg/kg body weight), P2 (4 mg/kg body weight) and P3 (8 mg/kg body weight). Before and after STZ injection, the body weight and fasting blood glucose were measured. The body weight and fasting blood glucose were measured on the 1 st , 7 th , and 14 th day of alpha-mangostin treatment. Alpha-mangostin was given orally for 14 days. On the 15 th day, the plasma BUN and creatinine level were measured using Pentra C 200. Interestingly, the administration of alpha-mangostin was able to lower the plasma BUN and creatinine level, and also the ameliorate-damaged renal proximal tubular epithelial cells of the kidney in diabetic mice leseened significantly.

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“…Cisplatin-induced renal cell damage is dependent on apoptosis induced by DNA damage [ 36 , 37 ]. Apoptosis in renal tubular cells has been observed in several kinds of renal disorders [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect ofArtemisia asiaticaExtract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage

Park

Lee

Jang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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The present study investigated the renoprotective effect of an Artemisia asiatica extract and eupatilin in kidney epithelial (LLC-PK1) cells. Although cisplatin is effective against several cancers, its use is limited due to severe nephrotoxicity. Eupatilin is a flavonoid compound isolated from the Artemisia plant and possesses antioxidant as well as potent anticancer properties. In the LLC-PK1 cellular model, the decline in cell viability induced by oxidative stress, such as that induced by cisplatin, was significantly and dose-dependently inhibited by the A. asiatica extract and eupatilin. The increased protein expressions of phosphorylated JNK and p38 by cisplatin in cells were markedly reduced after A. asiatica extract or eupatilin cotreatment. The elevated expression of cleaved caspase-3 was significantly reduced by A. asiatica extract and eupatilin, and the elevated percentage of apoptotic cells after cisplatin treatment in LLC-PK1 cells was markedly decreased by cotreatment with A. asiatica extract or eupatilin. Taken together, these results suggest that A. asiatica extract and eupatilin could cure or prevent cisplatin-induced renal toxicity without any adverse effect; thus, it can be used in combination with cisplatin to prevent nephrotoxicity.

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Protective Effect of Esculin on Streptozotocin-Induced Diabetic Renal Damage in Mice

Cited by 57 publications

References 35 publications

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice

Protective Effect ofArtemisia asiaticaExtract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage

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