Protective effect of erdosteine against naphthalene-induced oxidative stress in rats

Şehirli, Özer

doi:10.12991/201014451

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lipid peroxidation has been suggested to be closely related to exercise-induced oxidative damage, and MDA is a good indicator of the degree of lipid peroxidation [6]. Several studies have shown that exhaustive exercises increase the concentration of lipid peroxides in liver.…”

Section: Discussionmentioning

confidence: 99%

<i>Ganoderma lucidum</i> Polysaccharide Strengthens Antioxidant Defense Systems against Exercise-Induced Oxidative Stress in Liver of Mice

Lin

Feng

Wang

2014

AMM

View full text Add to dashboard Cite

Ganoderma lucidum(G. lucidum), a medicinal fungus called ‘‘Lingzhi’’ in China is one of the most famous fungi in traditional Chinese medicine. For hundreds of years, this mushroom has been known as a traditional remedy for treatment of several diseases, such as hepatitis, hypertension, chronic bronchitis, bronchial asthma, cancer and others. Polysaccharide is an important pharmacological ingredient extracted from fruit bodies and mycelium ofG. lucidum. It has been extensively documented thatG. lucidumpolysaccharides (Gl-PS) had wide bioactivities, such as anti-aging, anti-tumor, hypoglycemic, immunomodulatory and immunotherapeutic activities [1]. In our previous studies, Gl-PS has been proven to have significant anti-hypoxia and anti-fatigue effects in mice [2], which suggesting that it might be beneficial to exercise-induced oxidative stress. Therefore, the purpose of this study was to investigate the effects of Gl-PS against exercise-induced oxidative stress in liver of mice.

show abstract

Section: Discussionmentioning

confidence: 99%

<i>Ganoderma lucidum</i> Polysaccharide Strengthens Antioxidant Defense Systems against Exercise-Induced Oxidative Stress in Liver of Mice

Lin

Feng

Wang

2014

AMM

View full text Add to dashboard Cite

show abstract

“…The evaluation of biochemical markers of liver function followed the previous method with modifications [6,10,21,37]. Thirty male Wistar rats were weighed and divided randomly into 6 groups.…”

Section: Evaluation Of Hepatic Biochemical Markersmentioning

confidence: 99%

The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence

PURKON¹,

KUSMIYATI²,

TRINOVANI³

et al. 2022

jrp

View full text Add to dashboard Cite

Hepatoprotectors are compounds or substances that have efficacy to protect liver cells against toxic substances result in liver damage. Liver damage caused by various factors, such as: viruses, bacteria, drugs that directly damage liver cells (such as acetaminophen, etc.), hypersensitivity reactions, hepatotoxic chemicals, toxins in food and pollution. Therefore, the development of the drug is still being tested to obtain more satisfactory results in terms of efficacy and the minimal side effects it causes. Until now, there has been no research on the hepatoprotector effect of the liverwort herbs ethanol extract of Marchantia paleacea Bertol. in a hepatotoxic-induced test animal model, especially with acetaminophen in rats. This study aimed to examine the potential hepatoprotector of the herbal liverworts extract of Marchantia paleacea Bertol. compare to Curcuma FCT ® . The hepatoprotector effect was determined by examining the biochemical levels of SGPT and SGOT, the percentage of liver index (% w/w) and histopathological feature of the liver. The increase in SGPT and SGOT levels in the liver tissue induced by acetaminophen to prove the toxicity of the liver tissue caused by acetaminophen. Marchantia paleacea Bertol ethanol extract with doses of 26 and 104 mg/kg bw in the measurement of serum levels of SGPT, SGOT, and liver index (% w/w) has shown decreased serum levels of SGPT, SGOT, and liver index (% w/w). In addition, the histological examination for scoring liver cell repair using the Manja Roenigk Histopathology Scoring Model method has shown a repair score for acetaminophen-induced liver tissue damage at both doses of the test extract (26 and 104 mg/kg bw). These findings suggest that 26 and 104 mg/kg bw have a potential protective effect on liver function against hepatotoxicity in rat livers. Thus, Marchantia paleacea Bertol. liverwort herb has great potential as a nutraceutical product, supplement, or traditional medicine that has hepatoprotective therapeutic efficacy.

show abstract

Attenuation of oxidative stress, inflammation and early markers of tumor promotion by caffeic acid in Fe-NTA exposed kidneys of Wistar rats

Rehman

Sultana

2011

Mol Cell Biochem

View full text Add to dashboard Cite

Iron nitrilotriacetate (Fe-NTA), a chief environmental pollutant, is known for its extensive toxic manifestations on renal system. In the present study, caffeic acid, one of the most frequently occurring phenolic acids in fruits, grains, and dietary supplements was evaluated for its shielding effect against the Fe-NTA-induced oxidative, inflammatory, and pathological damage in kidney. Fe-NTA was administered (9 mg Fe/kg body weight) intraperitoneally to the Wistar male rats on 20th day while caffeic acid was administered orally (20 and 40 mg/kg body weight) before administration of Fe-NTA. The intraperitoneal administration of Fe-NTA-enhanced lipid peroxidation, xanthine oxidase, and hydrogen peroxide generation with reduction in renal glutathione content, antioxidant enzymes, viz., catalase, glutathione peroxidase, and glutathione reductase. A sharp elevation in the levels of myloperoxidase, blood urea nitrogen (BUN), and serum creatinine has also been observed. Tumor promotion markers viz., ornithine decarboxylase (ODC) and [(3)H] thymidine incorporation into renal DNA were also significantly increased. Treatment of rats orally with caffeic acid (20 and 40 mg/kg body weight) resulted in a significant decrease in xanthine oxidase (P < 0.001), lipid peroxidation (P < 0.001), γ-glutamyl transpeptidase (P < 0.01), and H(2)O(2) (P < 0.01). There was significant recovery of renal glutathione content (P < 0.001) and antioxidant enzymes (P < 0.001). There was also a reversal in the enhancement of renal ODC activity, DNA synthesis, BUN, and serum creatinine (P < 0.001). All these changes were supported by histological observations. The results indicate that caffeic acid may be beneficial in ameliorating the Fe-NTA-induced oxidative damage and tumor promotion in the kidney of rats.

show abstract

Protective effect of erdosteine against naphthalene-induced oxidative stress in rats

Cited by 3 publications

References 29 publications

<i>Ganoderma lucidum</i> Polysaccharide Strengthens Antioxidant Defense Systems against Exercise-Induced Oxidative Stress in Liver of Mice

<i>Ganoderma lucidum</i> Polysaccharide Strengthens Antioxidant Defense Systems against Exercise-Induced Oxidative Stress in Liver of Mice

The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence

Attenuation of oxidative stress, inflammation and early markers of tumor promotion by caffeic acid in Fe-NTA exposed kidneys of Wistar rats

Contact Info

Product

Resources

About