Protective effect of ebselen on experimental testicular torsion and detorsion injury

Rifaioğlu, Murat Mehmet; Motor, Sedat; Davarcı, Işıl; Tuzcu, Kasım; Sefil, Fatih; Davarci, Mursel; Nacar, Ahmet

doi:10.1111/and.12204

Cited by 21 publications

(20 citation statements)

References 33 publications

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“…induced torsion–detorsion in adult rats for 2 h each, and showed the positive effect of ebselen in reducing histopathological damage, decreasing spermatogenesis, and increasing MDA and NO concentrations. These findings suggest that ebselen has scavenging properties against ROS …”

Section: Anti‐oxidant Drugs and Free Radical Scavengersmentioning

confidence: 71%

“…These findings suggest that ebselen has scavenging properties against ROS. 49 a-Lipoic acid is important for its role in dehydrogenase reactions in the mitochondria. [50][51][52] Ozbal et al treated rats that underwent 2-h of ischemia and 2-h of reperfusion, with a-lipoic acid applied 30 min before detorsion.…”

Section: Anti-oxidant Drugs and Free Radical Scavengersmentioning

confidence: 99%

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Testicular torsion–detorsion and potential therapeutic treatments: A possible role for ischemic postconditioning

et al. 2016

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Testicular torsion is a common urological emergency among adolescent boys and young men. Rotation of the testis and twisting of the spermatic cord rapidly leads to ischemia, resulting in a loss of germ cells. Thus, prompt diagnosis and urgent surgical intervention are required, but the subsequent release of the torsion induces reperfusion injury, which causes further damage to the ischemic testis. Testicular torsion -detorsion (ischemia-reperfusion) injury triggers the generation of reactive oxygen species, pro-inflammatory cytokines, neutrophil recruitment, lipid peroxidation, anoxia and apoptosis, which carry a significant risk of subsequent infertility. Previously, the effects of numerous pharmacological agents and treatments have been evaluated to prevent testicular ischemia-reperfusion injury in animal models. We propose a new treatment, especially postconditioning, to prevent adverse effects of ischemiareperfusion injury after testicular torsion-detorsion.

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Section: Anti‐oxidant Drugs and Free Radical Scavengersmentioning

confidence: 71%

Section: Anti-oxidant Drugs and Free Radical Scavengersmentioning

confidence: 99%

Testicular torsion–detorsion and potential therapeutic treatments: A possible role for ischemic postconditioning

et al. 2016

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“…The surgical procedure was carried out as previously described (Rifaioglu et al ., ). Under aseptic conditions, the rats were anesthetised with i.p.…”

Section: Methodsmentioning

confidence: 97%

“…In addition, imbalance of the oxidant/antioxidant status results in activation of inflammatory responses with increased release of inflammatory cytokines, which aggravates testicular tissue injury (Zhou et al ., ). In agreement with this line, reduction of oxidative/nitrosative stress effectively ameliorated torsion/detorsion (T/D)‐induced testicular injury in previous studies (Meštrović et al ., ; Rifaioglu et al ., ; Yulug et al ., ; Ozbek et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent protective effect of baicalin against testicular torsion-detorsion in rats

2016

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Testicular torsion/detorsion induces oxidative/nitrosative stress, inflammation and apoptosis of testicular tissues. Baicalin exerts antioxidant and anti-inflammatory properties. This study investigated the possible protective effect of baicalin against testicular torsion-detorsion injury in rats. Surgical testicular torsion was induced for 2 h, followed by detorsion which was continued for 24 h. Baicalin was administered in three different doses (25, 50 and 100 mg kg , by intraperitoneal injection). Each dose was given twice, the first 30 min before and the second 12 h after testicular detorsion. Baicalin, in a dose-dependent manner, decreased the torsion/detorsion-induced elevations of testicular malondialdehyde, nitric oxide, tumour necrosis factor-α, BCL2-associated X protein (Bax), cytosolic cytochrome c and caspase-3 and caspase-9 activities. Baicalin, dose dependently, attenuated the reductions of B-cell leucemia/lymphoma 2 (Bcl-2), and glutathione peroxidase and superoxide dismutase activities in testicular tissues resulted from torsion/detorsion. In addition, baicalin ameliorated the histopathological testicular tissue damage and reduced the expression of Fas ligand in rat testes exposed to torsion/detorsion in a dose-dependent manner. It was concluded that baicalin, dose dependently, ameliorated testicular injury induced by torsion/detorsion via its antioxidant, antinitrosative, anti-inflammatory and anti-apoptotic effects.

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“…It exhibits anti-atherosclerotic and renoprotective effects; therefore, clinical trials are currently investigating its efficacy against stroke and reperfusion injury (30). It is considered an antioxidant and ROS scavenger and reduces the oxidative biochemical and histopathological damage that occur following tIR (31).…”

Section: Dimethylsulfoxide (Dmso)mentioning

confidence: 99%

Medical perspective in testicular ischemia-reperfusion injury

Arena

Iacona

Antonuccio

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Testicular torsion or torsion of the spermatic cord is one of the most serious urological conditions. It causes testicular injury, which potentially leads to male subfertility. The turning of the spermatic cord and spermatic structures around themselves results in biochemical and histological changes; however, following testicular detorsion, tissues undergo reperfusion that causes more severe damage than that induced by ischemia. Since the primary causes of testicular damage are reactive oxygen species production, an increase in intra-mitochondrial calcium concentration and an increased rate of cellular apoptosis, different medications may potentially be effective. It seems that several medications, experimentally and sometimes clinically, serve an adjuvant role in the cellular damage that occurs following ischemia-reperfusion. Antioxidants, calcium channel blockers, phytotherapeutical medicinals, anaesthetics, hormones and platelet inhibitors may potentially create a solid basis for an adjuvant restoring therapy and ameliorate testicular function following torsion. The current study aimed to review the relevant literature and discuss the actions of a number of molecules that may protect the testes during ischemia/reperfusion injury.

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Protective effect of ebselen on experimental testicular torsion and detorsion injury

Cited by 21 publications

References 33 publications

Testicular torsion–detorsion and potential therapeutic treatments: A possible role for ischemic postconditioning

Testicular torsion–detorsion and potential therapeutic treatments: A possible role for ischemic postconditioning

Dose-dependent protective effect of baicalin against testicular torsion-detorsion in rats

Medical perspective in testicular ischemia-reperfusion injury

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