Protective effect of Diyarbakır watermelon juice on carbon tetrachloride-induced toxicity in rats

Altaş, Sevcan; Kızıl, Göksel; Kızıl, Murat; Ketani, Aydın; Haris, Parvez I.

doi:10.1016/j.fct.2011.06.064

Cited by 72 publications

(34 citation statements)

References 30 publications

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“…The high contents of phenolics and fl avonoids obtained in infusions, dietary supplements and methanolic milk thistle plant extract may depend on the part of the plant used. Phenolics and fl avonoids are very important plant components due to their radical scavenging properties (25,26). It is well known that fl avonoids have anticarcinogenic activity, antiallergenic, antiviral, antiageing and anti-infl ammatory properties.…”

Section: Phenolic and Fl Avonoid Content Of S Marianum Seed Extractmentioning

confidence: 99%

Assessment of the Antioxidant Activity of Silybum marianum Extract and Its Protective Effect against DNA Oxidation, Protein Damage and Lipid Peroxidation

Serçe¹,

Toptancı²,

Tanrıkut³

et al. 2016

Food Technol. Biotechnol.

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SummaryAntioxidant properties of ethanol extract of Silybum marianum (milk thistle) seeds was investigated. We have also investigated the protein damage activated by oxidative Fenton reaction and its prevention by Silybum marianum seed extract. Antioxidant potential of Silybum marianum seed ethanol extract was measured using diff erent in vitro methods, such as lipid peroxidation, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing power assays. The extract signifi cantly decreased DNA damage caused by hydroxyl radicals. Protein damage induced by hydroxyl radicals was also effi ciently inhibited, which was confi rmed by the presence of protein damage markers, such as protein carbonyl formation and by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The present study shows that milk thistle seeds have good DPPH free radical scavenging activity and can prevent lipid peroxidation. Therefore, Silybum marianum can be used as potentially rich source of antioxidants and food preservatives. The results suggest that the seeds may have potential benefi cial health eff ects providing opportunities to develop value-added products.

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Section: Phenolic and Fl Avonoid Content Of S Marianum Seed Extractmentioning

confidence: 99%

Assessment of the Antioxidant Activity of Silybum marianum Extract and Its Protective Effect against DNA Oxidation, Protein Damage and Lipid Peroxidation

Serçe¹,

Toptancı²,

Tanrıkut³

et al. 2016

Food Technol. Biotechnol.

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“…54,56,57,[202][203][204] Lycopene has a protective effect against neurological disorders including Alzheimer's and PD by reducing oxidative stress. [205][206][207][208][209][210][211] Lycopene supplementation of a rotenone-induced rat model of PD enhances the protective effect against oxidative stress and reduces neurobehavioral abnormalities. 208 However, bioavailability in the gastrointestinal tract was limited after oral administration.…”

Section: Nanolycopenementioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

102

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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“…Intake of watermelon juice increases plasma concentrations of lycopene, -carotene [2], and arginine [3,4], reduces chemical-induced hepatotoxicity [5] and proliferation of cancer cell line [6], and even relieves muscle soreness of athletes [7]. Moreover, the production of watermelon juice will reduce the seasonal excess of watermelons in summer.…”

Section: Introductionmentioning

confidence: 99%

Effect of Thermal Treatments on Quality and Aroma of Watermelon Juice

Wang

et al. 2018

Journal of Food Quality

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The effect of thermal treatments on the quality and aroma of watermelon juice was evaluated. Watermelon juice was pasteurized via ultrahigh temperature (UHT, pasteurized at 135 ∘ C for 2 s), low temperature long time (LTLT, pasteurized at 60 ∘ C for 30 min), and high temperature short time (HTST, pasteurized at 100 ∘ C for 5 min), respectively. UHT and LTLT reduced the total flora count and maintained the color of the pasteurized juice, while the HTST led to a significant color difference. A total of 27, 21, 22, and 21 volatiles were identified in the unpasteurized juice, UHT, LTLT, and HTST, respectively. The typical watermelon aroma, including (3 )-3-nonen-1-ol, (E)-2-nonen-1-ol, 1-nonanal, (2E)-2-nonenal, and (E,Z)-2,6-nonadienal, was abundant in the LTLT. Consequently, the aroma of the LTLT was similar to that of unpasteurized juice. Moreover, the shelf life of the LTLT reached 101 and 14 days at 4 and 25 ∘ C, respectively. Hence, the LTLT was the best way to maintain the quality and aroma of watermelon juice.

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Protective effect of Diyarbakır watermelon juice on carbon tetrachloride-induced toxicity in rats

Cited by 72 publications

References 30 publications

Assessment of the Antioxidant Activity of Silybum marianum Extract and Its Protective Effect against DNA Oxidation, Protein Damage and Lipid Peroxidation

Assessment of the Antioxidant Activity of Silybum marianum Extract and Its Protective Effect against DNA Oxidation, Protein Damage and Lipid Peroxidation

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Effect of Thermal Treatments on Quality and Aroma of Watermelon Juice

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Protective effect of Diyarbakır watermelon juice on carbon tetrachloride-induced toxicity in rats

Cited by 72 publications

References 30 publications

Assessment of the Antioxidant Activity of Silybum marianum Extract and Its Protective Effect against DNA Oxidation, Protein Damage and Lipid Peroxidation

Assessment of the Antioxidant Activity of Silybum marianum Extract and Its Protective Effect against DNA Oxidation, Protein Damage and Lipid Peroxidation

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Effect of Thermal Treatments on Quality and Aroma of Watermelon Juice

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Product

Resources

About

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models