Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice

Zhang, Fang; Zhang, Yongchun; Wang, Kaiming; Liu, Guangpu; Yang, Min; Zhao, Zhongxi; Li, Sanzhong; Cai, Jingyi; Cao, Ji‐Min

doi:10.1177/0394632015627160

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…DATS is one of the most studied compounds in various models of inflammatory diseases, both in vitro and in vivo. In relation to respiratory diseases, DATS administration has been shown to have a beneficial effect in naphthaleneinduced lung injury (65). DATS treatment was associated with elevation of GSH levels in lung tissue, inhibition of the production of serum TNF-a and IL-8, and suppression of lung inflammatory cell recruitment, in particular neutrophil infiltration (65).…”

Section: Natural Sulfur-containing Compoundsmentioning

confidence: 99%

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses

Bazhanov¹,

Ansar

Ivanciuc³

et al. 2017

Am J Respir Cell Mol Biol

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Hydrogen sulfide (HS) is a biologically relevant signaling molecule in mammals. Along with the volatile substances nitric oxide (NO) and carbon monoxide (CO), HS is defined as a gasotransmitter. It plays a physiological role in a variety of functions, including synaptic transmission, vascular tone, angiogenesis, inflammation, and cellular signaling. The generation of HS is catalyzed by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST). The expression of CBS and CSE is tissue specific, with CBS being expressed predominantly in the brain, and CSE in peripheral tissues, including lungs. CSE expression and activity are developmentally regulated, and recent studies suggest that CSE plays an important role in lung alveolarization during fetal development. In the respiratory tract, endogenous HS has been shown to participate in the regulation of important functions such as airway tone, pulmonary circulation, cell proliferation or apoptosis, fibrosis, oxidative stress, and inflammation. In the past few years, changes in the generation of HS have been linked to the pathogenesis of a variety of acute and chronic inflammatory lung diseases, including asthma and chronic obstructive pulmonary disease. Recently, our laboratory made the critical discovery that cellular HS exerts broad-spectrum antiviral activity both in vitro and in vivo, in addition to independent antiinflammatory activity. These findings have important implications for the development of novel therapeutic strategies for viral respiratory infections, as well as other inflammatory lung diseases, especially in light of recent significant efforts to generate controlled-release HS donors for clinical therapeutic applications.

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Section: Natural Sulfur-containing Compoundsmentioning

confidence: 99%

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses

Bazhanov¹,

Ansar

Ivanciuc³

et al. 2017

Am J Respir Cell Mol Biol

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“…First, DATS has potent antioxidant activity, protecting normal cells from oxidative damage. 4 Second, previous studies have shown that DATS could fight against many human diseases, including cardiac disease, 5 diabetes, 6 inflammation, 7 and cancers. It has been reported that DATS exerts anticancer effects against pancreatic cancer, 8 melanoma, 9 and breast cancer.…”

Section: ■ Introductionmentioning

confidence: 99%

Induction of Apoptosis in Human Papillary-Thyroid-Carcinoma BCPAP Cells by Diallyl Trisulfide through Activation of the MAPK Signaling Pathway

Pan

Zhang²,

Xu³

et al. 2018

J. Agric. Food Chem.

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This study aimed to elucidate the potential effects of diallyl trisulfide (DATS) on human papillary-thyroid-carcinoma BCPAP cells and its underlying mechanisms. DATS is an organosulfur compound derived from garlic. In this study, we demonstrated that compared with the solvent control, DATS treatment at concentrations of 5, 10, and 20 μΜ decreased cell survival rates of BCPAP cells to 84.51 ± 2.67, 57.16 ± 1.18, and 41.22 ± 1.19% respectively. DATS also caused cell-cycle arrest at G0/G1 phase, and the proportion of cells arrested in G0/G1 phase rose from 68.8 ± 8.38 to 80.4 ± 8.38%, which eventually resulted in cell apoptosis through a mitochondrial apoptotic pathway in BCPAP cells. Further evidence showed that DATS activated ERK, JNK, and p38, members of the MAPK family. Moreover, ERK and JNK inhibitors partially reversed apoptosis in BCPAP cells induced by DATS treatment. Taken together, our results demonstrated that DATS exerted an apoptosis-inducing effect on papillary-thyroid-cancer cells via activation of the MAPK signaling pathway, which shed light on a prospective therapeutic target for thyroid-cancer treatment.

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“…Diallyl trisulfide (DATS), a sulfur compound derived from garlic, has various biological properties, such as anticancer (Liu et al 2016 ; Pandrangi 2015 ; Ma et al 2014 ; Hung et al 2014 ; Shin et al 2014 ; Zhou et al 2009 ; Chandra-Kuntal et al 2013 ; Wu et al 2004 ; Xiao et al 2004 , 2006 ; Li et al 2012 ; Shankar et al 2008 ), antiangiogenic (Lai et al 2015 ) and anti-inflammatory (Zhang et al 2016 ; Kuo et al 2013 ; Zeng et al 2008 ) effects.…”

Section: Introductionmentioning

confidence: 99%

“…Diallyl trisulfide demonstrates antioxidative effects, which are associated with the changes in the activity of antioxidant enzymes and the level of glutathione (Wu et al 2004 ; Zhang et al 2016 ; Zeng et al 2008 ; Mostafa et al 2016 ; Prabu and Sumedha 2014 ; Hu et al 2007 ).…”

Section: Introductionmentioning

confidence: 99%

A possible mechanism of inhibition of U87MG and SH-SY5Y cancer cell proliferation by diallyl trisulfide and other aspects of its activity

et al. 2017

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The study was conducted to elucidate the mechanism of antiproliferative and antioxidative action of diallyl trisulfide (DATS), a garlic-derived organosulfur compound. Changes in the l-cysteine desulfuration, and the levels of cystathionine and non-protein thiols in DATS-treated human glioblastoma (U87MG) and neuroblastoma (SH-SY5Y) cells were investigated. The inhibition of proliferation of the investigated cells by DATS was correlated with an increase in the inactivated form of Bcl-2. In U87MG cells, an increased level of sulfane sulfur and an increased activity of 3-mercaptopyruvate sulfurtransferase (MPST) and rhodanese, the enzymes involved in sulfane sulfur generation and transfer, suggest that DATS can function as a donor of sulfane sulfur atom, transferred by sulfurtransferases, to sulfhydryl groups of cysteine residues of Bcl-2 and in this way lower the level of active form of Bcl-2 by S-sulfuration. Diallyl trisulfide antioxidative effects result from an increased level of cystathionine, a precursor of cysteine, and an increased glutathione level. MPST and rhodanese, the level of which is increased in the presence of DATS, can serve as antioxidant proteins.

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Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice

Cited by 14 publications

References 42 publications

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses

Induction of Apoptosis in Human Papillary-Thyroid-Carcinoma BCPAP Cells by Diallyl Trisulfide through Activation of the MAPK Signaling Pathway

A possible mechanism of inhibition of U87MG and SH-SY5Y cancer cell proliferation by diallyl trisulfide and other aspects of its activity

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