Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats

Gürler, Mukaddes; Selçuk, Engin Burak; Özerol, Beyza Güzide; Tanbek, Kevser; Taşlıdere, Elif; Yıldız, Azibe; Yağın, Fatma Hilal; Gürel, Elif

doi:10.1080/01480545.2022.2084103

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…Dexpanthenol (Dex) is a biologically active analogue of pantothenic acid that exhibits anti-oxidative and anti-inflammatory effects and stimulates epithelialization [ 18 ]. Dex has been reported to have protective effects in several organs [ [19] , [20] , [21] ]. Furthermore, the antioxidative and anti-inflammatory features of Dex were highlighted as potential ameliorative mechanisms in various cardiac injury models [ [22] , [23] , [24] ].…”

Section: Introductionmentioning

confidence: 99%

Dexpanthenol ameliorates lipopolysaccharide-induced cardiovascular toxicity by regulating the IL-6/HIF1α/VEGF pathway

Ozcan,

Savran,

Kumbul Doguc

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Dexpanthenol ameliorates lipopolysaccharide-induced cardiovascular toxicity by regulating the IL-6/HIF1α/VEGF pathway

Ozcan,

Savran,

Kumbul Doguc

et al. 2024

Heliyon

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“…MTX has a structure similar to FH2, so it is competitively bound with DHFR, so the FH4 was not produced, and this affects DNA and RNA synthesis [15][16]. MTX is used to treat a variety of illnesses, including cancer, autoimmune disease, ectopic pregnancy, and asthma [10,[17][18]. Low doses suppress neutrophil chemotaxis, which has antiinflammatory benefits [19].…”

Section: ■ Introductionmentioning

confidence: 99%

Methotrexate-Polymer Nanocomposites for Targeted Pulmonary Drug Delivery

AL-Sarayrah,

Hussein-Al-Ali,

Haddad

et al. 2024

Indones. J. Chem.

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Nanocomposite formulation is a suitable technology that enables the development of successful dry powder inhalers. The methotrexate (MTX) and polyamide-disulfide (polymer) were used as a model to form MTX-polymer nanocomposites. Different amounts of the independent variable, MTX (0.025 and 0.050 g), polymer (0.05 and 0.01 g), pH (6.7 and 11.3), and across-linker ferric chloride (FeCl3) (0.05 and 0.10 g) were used. The loading efficiency and particle size were dependent variables. The optimized formula can be obtained with the highest loading efficiency and optimum particle size. This formula can be collected by using 0.025 g of drug, 0.079 g of polymer, 0.050 g of FeCl3, and pH = 6.7. The release of MTX from the nanocomposites occurs in two release steps; the first release step starts from the beginning up to 60 min, followed by a continuous release phase within 60 min. The results of the NGI analysis demonstrated that 28.1% of the nominated dose in each puff reached the lower parts of the respiratory system, an indication that the nanocomposites can be used in the delivery of MTX as a respiratory system.

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Sitagliptin exhibits protective effects against methotrexate-induced testicular toxicity: The involvement of oxidative stress-related factors

Khezri,

Pashaei,

Ghasemnejad-Berenji

et al. 2024

Reproductive Toxicology

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Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats

Cited by 3 publications

References 52 publications

Dexpanthenol ameliorates lipopolysaccharide-induced cardiovascular toxicity by regulating the IL-6/HIF1α/VEGF pathway

Dexpanthenol ameliorates lipopolysaccharide-induced cardiovascular toxicity by regulating the IL-6/HIF1α/VEGF pathway

Methotrexate-Polymer Nanocomposites for Targeted Pulmonary Drug Delivery

Sitagliptin exhibits protective effects against methotrexate-induced testicular toxicity: The involvement of oxidative stress-related factors

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