Protective effect of dexmedetomidine on noise‐induced hearing loss

Wen, Jian; Xiao, Ying; Bai, Yang; Xu, Min

doi:10.1002/lary.24425

Cited by 8 publications

(5 citation statements)

References 39 publications

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“…Another factor contributing to the inconsistency between our results and those reported in the Wang et al study is that the anesthetic dexmedetomidine (S-enantiomer of medetomidine - used in our study) has been found to be protective against noise-induced hearing loss [ 46 , 47 ]. Overall, Wang et al’s results were strong in comparison to findings from several other trials, which demonstrated only a moderate protective effect (i.e., slightly more pronounced than the present results) of glucocorticoids after noise exposure in guinea pigs [ 48 , 49 ].…”

Section: Discussioncontrasting

confidence: 75%

Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A

Landegger

Honeder

Zhu

et al. 2016

J Negat Results BioMed

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BackgroundSelective glucocorticoid receptor modulators (SEGRMs) comprise a novel class of drugs promising both reduced side effects and similar pharmacological potency relative to glucocorticoids, which presently serve as the only clinical treatment for many otologic disorders. In the first otologic SEGRM experiment in an animal model of noise trauma, we compare the effects of Compound A (a SEGRM) and dexamethasone (potent glucocorticoid).MethodsForty adult guinea pigs received experimental treatment once daily for ten days. The animals were divided into four cohorts based on the treatment received: Compound A (1 mg/kg or 3 mg/kg), dexamethasone (1 mg/kg) as gold standard, or water as negative control. After five applications, animals were exposed to broadband noise (8–16 kHz) at 115 dB for three hours. Hearing thresholds were determined by recording auditory brainstem responses to clicks and noise bursts (1–32 kHz) and were assessed a week prior to and immediately after exposure, as well as on days 1, 3, 7, 14, 21, and 28. Cochleae were prepared as whole-mounts or embedded and sectioned for histological analysis.ResultsRelative to the control treatments, Compound A failed to preserve auditory thresholds post-noise exposure with statistical significance. Histological analyses confirm the physiological result.ConclusionThe present findings suggest that Compound A does not have substantial otoprotective capacities in a noise trauma model.

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Section: Discussioncontrasting

confidence: 75%

Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A

Landegger

Honeder

Zhu

et al. 2016

J Negat Results BioMed

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“…Protection from temporary threshold shift (TTS) under sedation/anesthesia might be due to a diminished sympathetic influence [ 46 ]. After noise exposure, dexmedetomidine displayed protective effects against NIHL [ 47 ]. In mice, manipulation of adrenergic inputs to the cochlea confirmed that SNS regulates cochlear blood flow in response to intense loud sound exposure [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Norepinephrine protects against cochlear outer hair cell damage and noise-induced hearing loss via α2A-adrenergic receptor

Tian,

Yang,

Wang

et al. 2024

BMC Neurosci

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Background The cochlear sympathetic system plays a key role in auditory function and susceptibility to noise-induced hearing loss (NIHL). The formation of reactive oxygen species (ROS) is a well-documented process in NIHL. In this study, we aimed at investigating the effects of a superior cervical ganglionectomy (SCGx) on NIHL in Sprague-Dawley rats. Methods We explored the effects of unilateral and bilateral Superior Cervical Ganglion (SCG) ablation in the eight-ten weeks old Sprague-Dawley rats of both sexes on NIHL. Auditory function was evaluated by auditory brainstem response (ABR) testing and Distortion product otoacoustic emissions (DPOAEs). Outer hair cells (OHCs) counts and the expression of α2A-adrenergic receptor (AR) in the rat cochlea using immunofluorescence analysis. Cells culture and treatment, CCK-8 assay, Flow cytometry staining and analysis, and western blotting were to explore the mechanisms of SCG fibers may have a protective role in NIHL. Results We found that neither bilateral nor unilateral SCGx protected the cochlea against noise exposure. In HEI-OC1 cells, H2O2-induced oxidative damage and cell death were inhibited by the application of norepinephrine (NE). NE may prevent ROS-induced oxidative stress in OHCs and NIHL through the α2A-AR. Conclusion These results demonstrated that sympathetic innervation mildly affected cochlear susceptibility to acoustic trauma by reducing oxidative damage in OHCs through the α2A-AR. NE may be a potential therapeutic strategy for NIHL prevention.

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“…old) were used. All guinea pigs passed a click-evoked ABR hearing screening and had hearing thresholds ≤ 20 dB SPL ( Wen, Xiao, Bai, & Xu, 2013 ), and were without any history of noise exposure or apparent developmental disorders. All guinea pigs were placed under sedation using an initial dose of intramuscular injection of a mixture of Zoletil (30 mg/kg, Virbac, Carros, France) and Xylazine (10 mg/kg, Bayer, Leverkusen, Germany) before audiological testing.…”

Section: Methodsmentioning

confidence: 99%

Recording Frequency-following Responses to Voice Pitch in Guinea Pigs: Preliminary Results

et al. 2014

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Although scalp-recorded frequency-following response (FFR) to voice pitch has shown great potential to examine pitch processing mechanisms in human participants and animals, few reports have addressed the test-retest reliability of such a response in an animal model. The purpose of this study was to investigate the feasibility and reliability of recording such a response in an animal model and to evaluate the extent to which the response could be separated from background noise. A Chinese monosyllable with a rising pitch was used to elicit the FFR to voice pitch in four guinea pigs. Four objective measures (Root-Mean-Square, Amplitude, Tracking Accuracy, Frequency Error, and Slope Error) were computed from recorded brain waves and were used to examine the phase-locking magnitude and test-retest reliability of the response. Results demonstrated that the animal model produced FFR trends that were repeatable, reliable, and significantly different from responses to the background noise.

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Protective effect of dexmedetomidine on noise‐induced hearing loss

Abstract: Dexmedetomidine displayed protective effects against NIHL in this animal model, suppressing activation of the sympathetic nervous system and improving CoBF. These findings could have clinical relevance and deserve further investigation.

Cited by 8 publications

References 39 publications

Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A

Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A

Norepinephrine protects against cochlear outer hair cell damage and noise-induced hearing loss via α2A-adrenergic receptor

Recording Frequency-following Responses to Voice Pitch in Guinea Pigs: Preliminary Results

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