Protective effect of dendrodoine analog, an aminothiazole derivative against X-radiation induced hepatocellular damage in mice

Kalpana, K; Vishwanathan, P.; Thayalan, Kuppusamy; Menon, Venugopal P.

doi:10.1016/j.etap.2012.09.002

Cited by 3 publications

(3 citation statements)

References 59 publications

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Section: -Aminothiazoles As Antioxidant Agentsmentioning

confidence: 99%

“…In addition, 4-aminothiazole hybrid 89 was an effective radio protector against radiation-induced damage in the liver of mice. In addition, 4-aminothiazole scaffold 89 can protect the mouse myocardium against damage and one of the possible reasons behind this protective effect can be attributed to its antioxidant property [49][50][51]. Claisen-Schmidt condensation of 2-acetylamino-5-(4-acetyl-phenylazo)-thiazole 93 with an equimolar ratio of aromatic and/or heterocyclic aldehydes in sodium hydroxide and water/ethanol medium led to the formation of chalcones which reacted with hydrazine hydrate in the presence of ethanol to afford 96 (Scheme 27).…”

Section: -Aminothiazoles As Antioxidant Agentsmentioning

confidence: 99%

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An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

2021

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Amongst sulfur- and nitrogen-containing heterocyclic compounds, the 2-aminothiazole scaffold is one of the characteristic structures in drug development as this essential revelation has several biological activities abiding it to act as an anticancer, antioxidant, antimicrobial and anti-inflammatory agent, among other things. Additionally, various 2-aminothiazole-based derivatives as medical drugs have been broadly used to remedy different kinds of diseases with high therapeutic influence, which has led to their wide innovations. Owing to their wide scale of biological activities, their structural variations have produced attention amongst medicinal chemists. The present review highlights the recently synthesized 2-aminothiazole-containing compounds in the last thirteen years (2008–2020). The originality of this proposal is based on the synthetic strategies developed to access the novel 2-aminothiazole derivatives (N-substituted, 3-substituted, 4-substituted, multi-substituted, aryl/alkyl substituents or acyl/other substituents). The literature reports many synthetic pathways of these 2-aminothiazoles associated with four different biological activities (anticancer, antioxidant, antimicrobial and anti-inflammatory activities). It is wished that this review will be accommodating for new views in the expedition for rationalistic designs of 2-aminothiazole-based medical synthetic pathways.

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Section: -Aminothiazoles As Antioxidant Agentsmentioning

confidence: 99%

Section: -Aminothiazoles As Antioxidant Agentsmentioning

confidence: 99%

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

2021

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“…In this respect, natural compounds have been extensively researched. There is only a few studies about dendrodoine analogs ( Figure 1), and these studies usually based on antioxidant activity [1,[10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs

Şahin¹,

Biltekin²,

Yurttaş³

et al. 2020

Turk J Chem

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Marine compound dendrodoine was first obtained from tunicate species ( Dendrodo grossularia ). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources . Following its biological activities, novel analogs have been investigated recently. Synthesis of the analogs for this study is realized with uncommon thiazole closure, including methylene-carbonyl condensation. Structures are elucidated by NMR ( 1 , 13 C) and HRMS spectrums. As an alkaloid derivative, antioxidant properties were evaluated with DPPH and FRAP assays and antimicrobial effect with microdilution method. Among the series, 3bc-3cf showed higher antioxidant activity than those having 3 or 4-pyridyl substituents. There is lesser activity for 2-pyridyl activity for 2-pyridyl containing group, which may be a result of intramolecular interactions. No activity was observed against gram-negative bacteria at 250 μg/mL. 3ae and 3ce showed activity at 64 μg/mL against S. aureus and 3ae showed activity at 16 μg/mL against S. epidermidis gram-positive bacteria. Chloramphenicol showed activity against all microorganisms at 8–16 μg/mL. Sixteen original dendrodoine analogs have been defined by close/higher activity compared to dendrodoine analogs and Trolox.

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Protective effect of lycopene on whole body irradiation induced liver damage of Swiss albino mice: Pathological evaluation

Srinivasan¹,

Kalpana

Nagarajan

et al. 2014

Biomedicine & Preventive Nutrition

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Protective effect of dendrodoine analog, an aminothiazole derivative against X-radiation induced hepatocellular damage in mice

Cited by 3 publications

References 59 publications

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs

Protective effect of lycopene on whole body irradiation induced liver damage of Swiss albino mice: Pathological evaluation

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