Protective effect of DA-9601, an extract ofArtemisiae Herba, against naproxen-induced gastric damage in arthritic rats

Abstract

Gastrointestinal irritation is the most frequent adverse effect in patients chronically taking nonsteroidal antiinflammatory drugs (NSAIDs) for the treatment of arthritic conditions. Gastroprotective effect of DA-9601, a new antiulcer agent fromArtemisiae Herba extract, against NSAID was evaluated in a rat model of arthritis that is similar in many aspects to human rheumatoid arthritis. Daily oral dosing of naproxen (30 mg/kg), one of the most commonly used NSAID, induced apparent gastric lesions as well as a significant decrease in mucosal prostaglandin E(2) (PGE(2)) and prostaglandin F(1alpha) (PGF(1alpha)) levels. Coadministration of DA-9601 prevents naproxen-induced mucosal injury and depletion, of prostaglandins, in a dose-related manner. DA-9601 did not alter the antiinflammatory or analgesic effect of naproxen. The present results suggest that DA-9601 may be useful as a mucoprotectant against NSAIDs in clinical practice.

Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression

“…Eupatilin, a phytopharmaceutical derived from Artemisia asiatica , has been reported to possess antioxidative and cytoprotective functions in various models of gastric mucosal damage. (18-20)…”

Involvement of oxidative stress in experimentally induced reflux esophagitis and Barrett’s esophagus: clue for the chemoprevention of esophageal carcinoma by antioxidants

“…DA-9601, an ethanol extract of Artemisia asiatica, was reported to possess antioxidative and cytoprotective actions against various gastric mucosal damages and experimentally induced colitis. This new phytopharmaceutical possessing antioxidative action can scavenge the superoxide and hydroxyl radicals, which lessened the severity of trinitobenzoic acid-induced colitis [15,16]. DA-9601 was also reported to be effective in attenuating cerulein-induced pancreatitis through reducing lipid peroxidation and inducing apoptosis in damaged pancreatic acinar cells [17].…”

Inhibitory effects of the standardized extract (DA‐9601) of Artemisia asiatica Nakai on phorbol ester–induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase‐2 expression, inducible nitric oxide synthase expression and nuclear transcription factor κB activation in mouse skin

“…A. asiatica Nakai has been frequently used in traditional Asian medicine for the treatment of such diseases as inflammation, cancer and microbial infection. The standardized formulation (DA‐9601) prepared from the ethanol extract of A. asiatica possesses antioxidative and antiinflammatory activities, which contribute to its protective effects against experimentally induced gastric damage8–12 and pancreatitis 13. Oral administration of DA‐9601 at 30 or 100 mg/kg 30 min prior to generation of reflux esophagitis in male Sprague‐Dawley rats significantly attenuated esophageal mucosal damage, which was more prominent than the effect of ranitidine, a proton pump inhibitor 8–10.…”