Protective effect of D-psicose against testicular atrophy induced by di(2-ethylhexyl) phthalate

Suna, Shigeru; Tokuda, Masaaki; Hirao, Tomohiro; Yamaguchi, Fuminori; Miyatake, Nobuyuki; Suzue, Takeshi; Asakawa, Fumiyuki; Jitsunari, Fumihiko; Izumori, Ken

doi:10.1080/00207233.2013.810854

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…Therefore, MEHP is considered to be a substance directly involved in testicular toxicity [18][19][20]. In our studies, plasma or testicular MEHP concentrations were closely associated with the degree of testicular atrophy [25,26,[45][46][47]. In addition, 4-week-old rats showed higher susceptibility than 5-week-old rats.…”

Section: Dehp-induced Testicular Atrophy In Ratsmentioning

confidence: 82%

“…Furthermore, testicular MDA production after oral administration of 2 g/kg DEHP was almost suppressed by pretreatment with 4% D-allulose water or 4% D-allose water (Figure 3). Furthermore, D-allulose water with a concentration of 2% or more showed almost complete protection against DEHP (1 w/w %) diet -induced testicular atrophy for up to 2 weeks (Figure 4, 5) [25,[45][46][47]. As shown in Figure 6, testis sections from DEHP-only given rats showed degeneration of the seminiferous tubules and sloughing of germ cells into the tubular lumen.…”

Section: Protective Potency Of D-allulosementioning

confidence: 99%

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Protective potency of free radical scavengers against DEHP-induced testicular atrophy: A mini-review

Suna¹,

Tokuda²,

Jitsunari³

2023

World J. Bio. Pharm. Health Sci.

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Contamination with the plasticizer di(2-ethylhexyl) phthalate (DEHP) is widespread worldwide. DEHP has been found to have testicular toxicity in animal experiments, and is suspected to be reproductively toxic to mammals, including humans. Therefore, it is important to explore the effects of prophylaxis on DEHP-induced reproductive toxicity, such as testicular atrophy. The DEHP metabolite mono(2-ethylhexyl) phthalate (MEHP) is a potent oxidative stress factor and is thought to be an active toxicant involved in testicular damage. For this reason, free radical scavengers that protect the testis from inflammation and generation of reactive oxygen species are considered to be effective prophylactic agent. The authors discuss the efficacy of several free radical scavengers in preventing testicular atrophy. The efficacy of these free radical scavengers was revealed in a DEHP mixed diet exposure experiment. Examples include nicotinic acid, caffeine, ethanol, and the rare sugar D-allulose.

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Section: Dehp-induced Testicular Atrophy In Ratsmentioning

confidence: 82%

Section: Protective Potency Of D-allulosementioning

confidence: 99%

Protective potency of free radical scavengers against DEHP-induced testicular atrophy: A mini-review

Suna¹,

Tokuda²,

Jitsunari³

2023

World J. Bio. Pharm. Health Sci.

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“…DEHP administered orally is rapidly hydrolyzed by pancreatic lipase [24] and mucosal esterase [25] in the gastrointestinal tract to mono-(2ethylhexyl) phthalate (MEHP), which is the most toxic metabolite of DEHP. MEHP has been shown to be a direct acting agent that disrupts the function of Sertoli and Leydig cells and also induces oxidative stress in the germ cells [26,27,20] leading to cellular apoptosis. On the other hand, ethanol is known to have a hydroxyl radical scavenging effect [28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have shown the toxic effects of DEHP on male reproductive organs in the rodents at growth stages [9][10][11][12][13][14][15][16][17][18][19]. Although the pathogenesis of testicular atrophy by DEHP is yet unclear, this injury has been suggested to be due to oxidative stress induced by mono (2-ethylhexyl) phthalate (MEHP), a metabolite of DEHP [20].…”

Section: Introductionmentioning

confidence: 99%

Effect of dilute Ethanol Intake on DEHP (di (2-ethylhexyl) phthalate)-induced Testicular Atrophy

Suna¹,

Jitsunari²

2022

JPPR

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Background: Di(2-ethylhexyl) phthalate (DEHP) is the most commonly used as a plasticizer for polyvinyl chloride (PVC), but recently, concern has arisen over the DEHP which may act as a reproductive toxicant to humans. On the other hand, ethanol is the most common supplement of beverages and foods, and so many persons ingest a large quantity of ethanol in daily life. However, interactions between ethanol and DEHP toxicity are not well known. Method: To investigate the effect of dilute ethanol ingestion on the DEHP induced testicular atrophy, rats were received a 1% (w/w) DEHP diet and 2.5 or 5% (v/v) ethanol water for 7 days. Result: The rats treated with DEHP-diet alone for 7 days were observed significant testicular weight loss. On the other hand, testicular weight loss was significantly suppressed in rats treated with DEHP diet and ethanol water. A significant negative correlation between relative testicular weight (as a percentage of body weight) and testicular MEHP concentration was found among rats treated with DEHP-free diet (Control) and DEHP diet alone. Most of the data plots for the DEHP diet plus ethanol water group were scattered above the regression line. Conclusion: These results suggest that dilute ethanol may be effective in preventing DEHP testicular atrophy. However, the mechanism of prevention is unknown and further research is needed.

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Gut microbiota dysbiosis might be responsible to different toxicity caused by Di-(2-ethylhexyl) phthalate exposure in murine rodents

Wang

Chen

Tian

et al. 2020

Environmental Pollution

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Protective effect of D-psicose against testicular atrophy induced by di(2-ethylhexyl) phthalate

Cited by 3 publications

References 17 publications

Protective potency of free radical scavengers against DEHP-induced testicular atrophy: A mini-review

Protective potency of free radical scavengers against DEHP-induced testicular atrophy: A mini-review

Effect of dilute Ethanol Intake on DEHP (di (2-ethylhexyl) phthalate)-induced Testicular Atrophy

Gut microbiota dysbiosis might be responsible to different toxicity caused by Di-(2-ethylhexyl) phthalate exposure in murine rodents

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