Protective Effect of Curcumin Against Oxidative Stress-Induced Injury in Rats with Parkinson’s Disease Through the Wnt/ β-Catenin Signaling Pathway

Wang, Yunliang; Ju, Bo; Zhang, Yuzhen; Yin, Huaizhi; Liu, Yajun; Wang, Shanshan; Zeng, Zhaolin; Yang, Xiaopeng; Wang, Haitao; Li, Jinfeng

doi:10.1159/000484302

Cited by 70 publications

(42 citation statements)

References 34 publications

(38 reference statements)

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“…Several experiments also reported that curcumin in PD is able to counteract the decrease in the enzyme tyrosine hydroxylase-the rate-limiting enzyme involved in dopamine synthesis-which has been suggested to be causative in the onset of PD [89]. Curcumin exerts neuroprotective effects in PD by inhibiting oxidative stress through the decrease in ROS, TNF-α and IL-6 and the concomitant increase in Glutathione (GSH) levels [90]. On the other hand, in PD, curcumin not only acts as an antioxidant, but also as anti-inflammatory, reducing the production of TNF-α and Interleukin-6 (IL-6).…”

Section: Parkinson's Diseasementioning

confidence: 99%

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Meo

Valentino²,

Petillo

et al. 2020

IJMS

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The interest in dietary polyphenols in recent years has greatly increased due to their antioxidant bioactivity with preventive properties against chronic diseases. Polyphenols, by modulating different cellular functions, play an important role in neuroprotection and are able to neutralize the effects of oxidative stress, inflammation, and apoptosis. Interestingly, all these mechanisms are involved in neurodegeneration. Although polyphenols display differences in their effectiveness due to interindividual variability, recent studies indicated that bioactive polyphenols in food and beverages promote health and prevent age-related cognitive decline. Polyphenols have a poor bioavailability and their digestion by gut microbiota produces active metabolites. In fact, dietary bioactive polyphenols need to be modified by microbiota present in the intestine before being absorbed, and to exert health preventive effects by interacting with cellular signalling pathways. This literature review includes an evaluation of the literature in English up to December 2019 in PubMed and Web of Science databases. A total of 307 studies, consisting of research reports, review articles and articles were examined and 146 were included. The review highlights the role of bioactive polyphenols in neurodegeneration, with a particular emphasis on the cellular and molecular mechanisms that are modulated by polyphenols involved in protection from oxidative stress and apoptosis prevention.

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Section: Parkinson's Diseasementioning

confidence: 99%

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Meo

Valentino²,

Petillo

et al. 2020

IJMS

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“…colon cancer, central nervous system diseases and respiratory diseases (13)(14)(15). Currently, a number of studies have demonstrated the therapeutic effect of curcumin on cancer, particularly lung cancer (16,17).…”

Section: Anticancer Effects Of Curcumin On Nude Mice Bearing Lung Canmentioning

confidence: 99%

Anticancer effects of curcumin on nude mice bearing lung cancer A549 cell subsets SP and NSP cells

Yang

et al. 2018

Oncol Lett

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Curcumin is a key polyphenolic curcuminoid extracted from the root of turmeric rhizome Curcuma longa Linn, which is a frequently used Chinese herb for the treatment of cancer. The aim of the present study was to investigate the mechanism of the inhibitory effects of curcumin on nude mice with lung cancer A549 cell subsets side population (SP) and non-SP (NSP) cells. BALB/c mice were subcutaneously injected with the tumor cells of A549 SP or NSP subsets consisting of 1x10 9 cells/l (0.2 ml in total). After 16 days of inoculation with A549, the mice were intraperitoneally injected with curcumin (100 mg/kg, 0.2 ml) once every other day, eight times in total. A series of assays were performed to detect the effects of curcumin on: i) Tumor weight and size; ii) Notch and hypoxia inducible factor 1 (HIF-1) mRNA expression by quantitative polymerase chain reaction; and iii) vascular endothelial growth factor (VEGF) and nuclear factor-κB (NF-κB) by immunohistochemistry. It was determined that curcumin decreased the tumor weight and size, downregulated the expression of Notch and HIF-1 mRNA and suppressed the VEGF and NF-κB expression. These results indicated that curcumin inhibited lung cancer growth through the regulation of angiogenesis mediated by VEGF signaling.

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“…Curcumin has, in fact, been shown to reduce 6-OHDA-induced neurotoxicity in a human dopaminergic cell line (SH-SY5Y) via attenuation of reactive oxygen species production, p53 phosphorylation, and reduction of the Bax/Bcl-2 ratio [ 35 ]. Moreover, curcumin was found to protect dopaminergic neurons from 6-OHDA-induced toxicity via restoration of striatal dopamine, dopamine metabolite, dihydroxyphenylacetic acid, and homovanillic acid in a 6-OHDA model of PD [ 36 ] In these studies, the neuroprotective action of curcumin may be mediated by a reduction of oxidative stress due to its iron-chelating property [ 37 ] or via the Wnt/β-catenin signaling pathway [ 38 ] or modulating bFGF/NGF/TrkA/Hsp70 expressions in the SN [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Curcumin on the Nigrostriatal Pathway in a 6-Hydroxydopmine-Induced Rat Model of Parkinson’s Disease is Mediated by α7-Nicotinic Receptors

Nebrisi

Javed

Ojha

et al. 2020

IJMS

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Parkinson’s disease (PD) is a common neurodegenerative disorder, characterized by selective degeneration of dopaminergic nigrostriatal neurons. Most of the existing pharmacological approaches in PD consider replenishing striatal dopamine. It has been reported that activation of the cholinergic system has neuroprotective effects on dopaminergic neurons, and human α7-nicotinic acetylcholine receptor (α7-nAChR) stimulation may offer a potential therapeutic approach in PD. Our recent in-vitro studies demonstrated that curcumin causes significant potentiation of the function of α7-nAChRs expressed in Xenopus oocytes. In this study, we conducted in vivo experiments to assess the role of the α7-nAChR on the protective effects of curcumin in an animal model of PD. Intra-striatal injection of 6-hydroxydopmine (6-OHDA) was used to induce Parkinsonism in rats. Our results demonstrated that intragastric curcumin treatment (200 mg/kg) significantly improved the abnormal motor behavior and offered neuroprotection against the reduction of dopaminergic neurons, as determined by tyrosine hydroxylase (TH) immunoreactivity in the substantia nigra and caudoputamen. The intraperitoneal administration of the α7-nAChR-selective antagonist methyllycaconitine (1 µg/kg) reversed the neuroprotective effects of curcumin in terms of both animal behavior and TH immunoreactivity. In conclusion, this study demonstrates that curcumin has a neuroprotective effect in a 6-hydroxydopmine (6-OHDA) rat model of PD via an α7-nAChR-mediated mechanism.

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Protective Effect of Curcumin Against Oxidative Stress-Induced Injury in Rats with Parkinson’s Disease Through the Wnt/ β-Catenin Signaling Pathway

Cited by 70 publications

References 34 publications

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Anticancer effects of curcumin on nude mice bearing lung cancer A549 cell subsets SP and NSP cells

Neuroprotective Effect of Curcumin on the Nigrostriatal Pathway in a 6-Hydroxydopmine-Induced Rat Model of Parkinson’s Disease is Mediated by α7-Nicotinic Receptors

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