Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow

Awasthi, Himani; Tota, Santoshkumar; Hanif, Kashif; Nath, Chandishwar; Shukla, Rakesh

doi:10.1016/j.lfs.2009.11.007

Cited by 74 publications

(44 citation statements)

References 63 publications

(71 reference statements)

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“…Decrease in retention latency time in repeated trials demonstrates intact learning and memory function. Positive control rats showed increase in retention latency indicating cognitive impairment (Lannert and Hoyer 1998;Awasthi et al 2010). Administration of ACSF (icv) in vehicle control group did not hinder the learning and memory status thus ruling out the possibility of interference of drug vehicle.…”

Section: Discussionmentioning

confidence: 98%

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

2016

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There is strong evidence that mitochondrial dysfunction mediated oxidative stress results in aging and energy metabolism deficits thus playing a prime role in pathogenesis of Alzheimer's disease, neuronal death and cognitive dysfunction. Evidences accrued in empirical studies suggest the antioxidant, anticancer and anti-inflammatory activities of the phytochemical pterostilbene (PTS). PTS also exhibits favourable pharmacokinetic attributes compared to other stilbenes. Hence, in the present study, we explored the neuroprotective role of PTS in ameliorating the intracerebroventricular administered streptozotocin (STZ) induced memory decline in rats. PTS at doses of 10, 30 and 50 mg/kg, was administered orally to STZ administered Sprague-Dawley (SD) rats. The learning and memory tests, Morris water maze test and novel object recognition test were performed which revealed improved cognition on PTS treatment. Further, there was an overall improvement in brain antioxidant parameters like elevated catalase and superoxide dismutase activities, GSH levels, lowered levels of nitrites, lipid peroxides and carbonylated proteins. There was improved cholinergic transmission as evident by decreased acetylcholinesterase activities. The action of ATPases (Na ? K ? , Ca 2? and Mg 2? ) indicating the maintenance of cell membrane potential was also augmented. mRNA expression of battery of genes involved in cellular mitochondrial biogenesis and inflammation showed variations which extrapolate to hike in mitochondrial biogenesis and abated inflammation. The histological findings corroborated the effective role of PTS in countering STZ induced structural aberrations in brain.

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Section: Discussionmentioning

confidence: 98%

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

2016

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“…Emerging evidences also indicate that impairment in brain energy metabolism and cerebral circulation affect learning and memory function in animals and humans (Plaschke and Hoyer 1993;Wyper et al 1993;Honer et al 1988;Awasthi et al 2010;Tota et al 2010Tota et al , 2011. Recently, we have also shown that intracerebroventricular streptozotocin-induced memory impairment in rats was associated with significant reduction in central cholinergic function, CBF, and brain energy metabolism which was prevented by chronic administration of perindopril suggesting a possible role of central RAS (Tota et al 2012).…”

Section: Introductionmentioning

confidence: 85%

“…The animals were given a daily session of three trials per day. Latency time and distance traveled to reach the platform was recorded in each trial (Tota et al 2009Awasthi et al 2010).…”

Section: Evaluation Of Spatial Memory By Morris Water Maze Testmentioning

confidence: 99%

Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function

et al. 2012

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Rational Inhibition of renin-angiotensin system (RAS) improves cognitive functions in hypertensive patients. However, role of AT1 and AT2 receptors in memory impairment due to cholinergic hypofunction is unexplored. Objective This study investigated the role of AT1 and AT2 receptors in cerebral blood flow (CBF), cholinergic neurotransmission, and cerebral energy metabolism in scopolamineinduced amnesic mice. Methods Scopolamine was given to male Swiss albino mice to induce memory impairment tested in passive avoidance and Morris water maze tests after a weeklong administration of blocker of AT1 receptor, candesartan, and AT2 receptor, PD123, 319. CBF was measured by laser Doppler flowmetry. Biochemical and molecular studies were done in cortex and hippocampus of mice brain. Results Scopolamine caused memory impairment, reduced CBF, acetylcholine (ACh) level, elevated acetylcholinesterase (AChE) activity, and malondialdehyde (MDA). Administration of vehicle had no significant effect on any parameter in comparison to control. Candesartan prevented scopolamineinduced amnesia, restored CBF and ACh level, and decreased AChE activity and MDA level. In contrast, PD123, 319 was not effective. However, the effect of AT1 receptor blocker on memory, CBF, ACh level, and oxidative stress was blunted by concomitant blockade of AT2 receptor. Angiotensin-converting enzyme (ACE) activity, ATP level, and mRNA expression of AT1, AT2, and ACE remained unaltered. Conclusion The study suggests that activation of AT1 receptors appears to be involved in the scopolamine-induced amnesia and that AT2 receptors contribute to the beneficial effects of candesartan. Theses finding corroborated the number of clinical studies that RAS inhibition in hypertensive patients could be neuroprotective.

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“…All tissue samples were stored at −80°C until further analysis. To measure tissue nitrite, snap-frozen left ventricle heart sample was crushed in liquid nitrogen and 10% (w/v) tissue homogenate was prepared in ice cold 0.03 M sodium phosphate buffer by using Ultra-Turrax T25 (USA) homogenizer [28].…”

Section: Experimental Design and Sample Preparationmentioning

confidence: 99%

Atorvastatin Protects against Ischemia-Reperfusion Injury in Fructose-Induced Insulin Resistant Rats

Prakash

Khanna

Singh

et al. 2011

Cardiovasc Drugs Ther

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Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow

Cited by 74 publications

References 63 publications

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function

Atorvastatin Protects against Ischemia-Reperfusion Injury in Fructose-Induced Insulin Resistant Rats

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