Protective Effect of Coriander (Coriandrum sativum L.) on High-Fructose and High-Salt Diet-Induced Hypertension: Relevant to Improvement of Renal and Intestinal Function

Abstract

Hypertension has become a leading cardiovascular risk factor worldwide. In this study, we explored the salutary effects and relevant mechanisms of coriander (Coriandrum sativum L.), an herbal plant with culinary and medicinal values, on highfructose and high-salt diet (HFSD)-induced hypertension in SD rats. Our results showed that oral administration of coriander (1.0 or 2.0 g/kg•bw) effectively attenuated HFSD-induced elevation of systolic blood pressure, diastolic blood pressure, and mean arterial pressure. Coriander also increased the serum levels of vasodilator factors (PGI 2 , NO, and eNOS), decreased Na + retention and serum uric acid (UA) level, and ameliorated glucolipid profiles. qPCR results revealed that coriander downregulated the mRNA expression of NHE3, a Na + /H + exchanger responsible for Na + absorption, in kidney and small intestine. 16S rDNA sequencing showed that coriander altered the gut microbiota composition with the beneficial bacteria Bifidobacterium and Oscillibacter significantly enriched. Correlation analysis indicated that the abundance of Bifidobacterium was evidently correlated with levels of NHE3, NO, eNOS, and UA. LC−MS/MS analysis revealed that coriander contained a variety of flavonoids including rutin and quercetin. Conclusively, long-term consumption of coriander may ameliorate HFSD-induced hypertension by mitigating HFSDcaused abnormal changes in vascular endothelial function, renal and intestinal sodium absorption, glucolipid homeostasis, and gut microbiota in rats.

Effects of Coriandrum sativum on distant organ inflammation and apoptosis due to liver ischemia/reperfusion injury

“…It has been observed that it has an antioxidant protective effect against the oxidation of heavy metals in the kidneys [ 37 ]. Long-term consumption of CS has effects on vascular endothelial function, renal and intestinal sodium absorption, glucolipid homeostasis, and gut microbiota in rats [ 38 ].…”

Metabolomics study of flavonoids in Coreopsis tinctoria of different origins by UPLC–MS/MS

“…Linear ion trap (LIT) and triple quadrupole (QQQ) scans were obtained using a triple quadrupole-linear ion trap mass spectrometer (QTRAP; API 6500 Q TRAP LC/MS/MS System) equipped with an ESI Turbo Ion-Spray interface, operated in the positive and negative ion modes and controlled using Analyst 1.6.3 software (Sciex, Toronto, Canada). The ESI source operation parameters were set according to those reported by Wang et al (2022) . Flavonoid data were collected and identified by scheduled multiple reaction monitoring (MRM, New York, NW, USA).…”

“…Flavonoid data were collected and identified by scheduled multiple reaction monitoring (MRM, New York, NW, USA). Data acquisition was performed using Analyst 1.6.3 software (Sciex, Toronto, Canada) according to Wang et al (2022) . MultiQuant 3.0.3 software (Sciex, Toronto, Canada) was used to quantify all metabolites.…”

“…MultiQuant 3.0.3 software (Sciex, Toronto, Canada) was used to quantify all metabolites. The mass spectrometer parameters, including depolymerization potential (DP) and collision energy (CE), for individual MRM transitions were performed with further DP and CE optimization ( Liang et al, 2022 ; Wang et al, 2022 ). A specific set of MRM transitions was monitored during each period based on the metabolites eluted during each period ( Liang et al, 2022 ).…”